Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease

Abstract

A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.

1 . A medicament for preventive and/or therapeutic treatment of a bowel disease, which comprises a retinoid as an active ingredient. 
     
     
         2 . The medicament according to  claim 1 , wherein the bowel disease is an inflammatory bowel disease, irritable bowel syndrome, duodenal ulcer, acute enteritis, protein losing gastroenteropathy, colon cancer, ileus, apendicitis, hemorrhagic colitis, intestinal tuberculosis, intestinal Behcet's disease, or diverticulitis of colon. 
     
     
         3 . The medicament according to  claim 1 , wherein the bowel disease is an inflammatory bowel disease. 
     
     
         4 . The medicament according to  claim 1 , wherein the bowel disease is Crohn's disease. 
     
     
         5 . The medicament according to  claim 1 , wherein the retinoid is a non-natural retinoid. 
     
     
         6 . The medicament according to  claim 5 , wherein the retinoid has a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group. 
     
     
         7 . The medicament according to  claim 1 , wherein the retinoid is a retinoid binds to subtype α and subtype β of retinoic acid receptor RAR, or a retinoid binds to); the aforementioned medicament, wherein the retinoid is capable of binding to retinoic acid receptor RXR. 
     
     
         8 . The medicament according to  claim 6 , wherein the retinoid has a basic skeleton comprising a substituted phenyl group bound with benzoic acid or tropolone by means of a bridging group. 
     
     
         9 . The medicament according to  claim 1 , wherein the retinoid is 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)carboxamido]benzoic acid.