Methods and compositions for acid phosphatase-1 gene inhibition

Abstract

The ACP1 *A allele provides a means for diagnosing susceptibility of a human subject to hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome, a means for treating, or preventing the onset of, hyperlipidemia and metabolic syndrome, and a means for screening and identifying drugs suitable for use in treating or preventing hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome. Diagnostic kits are also provided.

1 . A method for inhibiting acid phosphatase-1 (ACP-1) activity in a cell, which comprises introducing into said cell a polynucleotide composition, wherein said polynucleotide composition interferes with a parameter selected from the group consisting of transcription, translation and both transcription and translation, of ACP-1. 
     
     
         2 . The method of  claim 1  wherein said polynucleotide composition comprises polydeoxyribonucleic acid. 
     
     
         3 . The method of  claim 1  wherein said polynucleotide composition comprises polyribonucleic acid. 
     
     
         4 . The method of  claim 1  wherein said polynucleotide composition hybridizes with an mRNA molecule that encodes an ACP-1 polypeptide. 
     
     
         5 . The method of  claim 1  wherein said polynucleotide composition comprises an antisense polynucleotide. 
     
     
         6 . A method of treating or preventing hyperlipidemia in a subject in need thereof, which comprises introducing into said cell a polynucleotide composition, wherein said polynucleotide composition interferes with a parameter selected from the group consisting of transcription, translation and both transcription and translation, of ACP-1. 
     
     
         7 . The method of  claim 6  wherein said polynucleotide composition comprises polydeoxyribonucleic acid. 
     
     
         8 . The method of  claim 6  wherein said polynucleotide composition comprises polyribonucleic acid. 
     
     
         9 . The method of  claim 6  wherein said polynucleotide composition hybridizes with an mRNA molecule that encodes an ACP-1 polypeptide. 
     
     
         10 . The method of  claim 6  wherein said polynucleotide composition comprises an antisense polynucleotide. 
     
     
         11 . An ACP-1 antisense nucleotide molecule. 
     
     
         12 . An ACP-1 interfering RNA molecule.