Aglyco products and methods of use

Abstract

Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which are immunogenic epitopes responsible for recognition of antigens by the immune system are provided. These glycoconjugates are useful in prevention of influenza virus binding to cells, treatment of schizophrenia and diagnosing chronic viral disease associated with development of cancer.

1 - 17 . (canceled) 
     
     
         18 . A method of diagnosing cancer associated with chronic viral disease in a patient comprising detecting transformation to malignant cells in said patient, said transformation being detected by a determination of an elevated level of aglycoprotein 10B antibody in blood or aglycoprotein antigenic peptides in blood or tissue of said patient. 
     
     
         19 . The method of  claim 18  wherein the cancer associated with chronic viral disease is hepatocarcinoma. 
     
     
         20 - 27 . (canceled) 
     
     
         28 . A method for diagnosing cancer in a patient which comprises determining the presence of aglycoprotein 10B antigenic peptide in the blood of said patient. 
     
     
         29 . A method for determining the presence of aglyco products in the blood or tissue of a patient which comprises 1) determining the amount of carbohydrate moieties of glycoproteins isolated from the blood or tissue of said patient; and 2) comparing the amount of said carbohydrate moieties to the amount of carbohydrate moieties associated with glycoproteins isolated from blood or tissue of healthy control individuals. 
     
     
         30 . The method of  claim 29  further comprising the step of determining the presence and concentration of antibodies to aglycopeptides in the blood of said patient. 
     
     
         31 . (canceled)