US2008241105A1PendingUtilityA1
Method and reagents for the enhancement of virus transduction in the bladder epithelium
Est. expiryDec 26, 2022(expired)· nominal 20-yr term from priority
A61P 35/00A61K 31/337A61K 47/26C12N 2710/10343A61P 35/04C12N 7/00A61K 9/0019A61P 43/00A61K 48/0083A61K 47/10C12N 2710/10332A61K 45/06A61K 31/7024A61K 35/761A61K 48/00Y02A50/30
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Claims
Abstract
Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Alternatively, the luminal surface of the bladder can be contacted first with a pretreatment composition comprising a transduction enhancing agent and, subsequently, with a composition comprising an oncolytic virus. Bladder treatment compositions comprising a transduction enhancing agent and an oncolytic virus are also described.
Claims
exact text as granted — not AI-modified1 - 93 . (canceled)
94 . A composition comprising:
a transduction enhancing agent; and an oncolytic virus; wherein the transduction enhancing agent has a structure represented by the following general formula (I) or the following general formula (II):
wherein x is a positive integer; and
wherein the concentration of the transduction enhancing agent is less than 0.025 wt/% of the composition.
95 . (canceled)Join the waitlist — get patent alerts
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