Kcnb: a novel potassium channel protein

Abstract

The present invention provides nucleic acid and protein sequences for a novel potassium channel protein, KCNB. The herein-disclosed sequences can be used for any of a number of purposes, including for the specific detection of KCNB, for the identification of molecules that associate with and/or modulate the activity of KCNB, to diagnose any of a number of conditions associated with KCNB or KCNB activity, or to modulate the number or activity of KCNB molecules in a mammal.

1 - 18 . (canceled) 
     
     
         19 . An antibody that selectively binds to a polypeptide comprising greater than 70% amino acid sequence identity to an amino acid sequence of SEQ ID NO: 1, or to a polypeptide comprising at least 30 contiguous amino acids of the amino acid sequence of SEQ ID NO: 1. 
     
     
         20 - 67 . (canceled) 
     
     
         68 . An antibody of  claim 19  that selectively binds to a polypeptide comprising greater than 90% amino acid sequence identity to an amino acid sequence of SEQ ID NO: 1. 
     
     
         69 . An antibody of  claim 19  that selectively binds to a polypeptide comprising greater than 95% amino acid sequence identity to an amino acid sequence of SEQ ID NO: 1. 
     
     
         70 . An antibody of  claim 19  that selectively binds to a polypeptide having the amino acid sequence of SEQ ID NO. 1 
     
     
         71 . An antibody of  claim 19  that selectively binds to a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO: 1, wherein the fragment is selected from the group consisting of the C-terminal domain, the M3 domain and the amino acid sequence from amino acid 30 to amino acid 70 of SEQ ID NO:1.