Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Abstract

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

1 . A composition comprising two or more compounds of the following formulae: 
       
         
           
           
               
               
           
         
       
       wherein:
 W′ is —CHR 7 —CH 2 — or —CH 2 —C(═O)—; and 
 R 7  is —OH or —NHSO 2 CH 2 CH 3 ; 
 
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         2 . The composition according to  claim 1 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         3 . The composition according to  claim 2 , wherein said composition further comprises 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         4 . The composition according to  claim 2 , wherein said composition further comprises 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         5 . The composition according to  claim 2 , wherein said composition further comprises 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         6 . The composition according to  claim 2 , wherein said composition further comprises 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         7 . The composition according to  claim 2 , wherein said composition further comprises 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         8 . The composition according to  claim 1 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         9 . The composition according to  claim 1 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         10 . The composition according to  claim 9 , further comprising: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         11 . The composition according to  claim 1 , wherein said two or more compounds are: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         12 . The composition according to  claim 11 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         13 . The composition according to  claim 11 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         14 . The composition according to  claim 11 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
         or pharmaceutically acceptable salts or stereoisomers thereof. 
       
     
     
         15 . The composition according to  claim 14 , wherein said composition further comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         16 . The composition according to  claim 11 , wherein said composition comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof. 
     
     
         17 . The composition according to  claim 16 , wherein said composition further comprises: 
       
         
           
           
               
               
           
         
       
       or pharmaceutically acceptable salts or stereoisomers thereof.