Compositions and methods for the therapy and diagnosis of breast cancer

Abstract

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

1 . An isolated polynucleotide comprising a sequence selected from the group consisting of:
 (a) the sequence provided in SEQ ID NO:474   (b) the complement of the sequence provided in SEQ ID NO:474   (c) sequences consisting of at least 20 contiguous residues of the sequence provided in SEQ ID NO:474;   (d) sequences that hybridize to the sequence provided in SEQ ID NO:474, under highly stringent conditions;   (e) sequences having at least 75% identity to the sequence of SEQ ID NO:474;   (f) sequences having at least 90% identity to the sequence of SEQ ID NO:474; and   (g) degenerate variants of the sequence provided in SEQ ID NO:474.   
     
     
         2 . An expression vector comprising a polynucleotide of  claim 1  operably linked to an expression control sequence. 
     
     
         3 . A host cell transformed or transfected with an expression vector according to  claim 2 . 
     
     
         4 . A composition comprising a first component selected from the group consisting of physiologically acceptable carriers and immunostimulants, and a second component comprising a polynucleotide according to  claim 1 . 
     
     
         5 . An oligonucleotide that hybridizes to the sequence recited in SEQ ID NO:474 under highly stringent conditions. 
     
     
         6 . A diagnostic kit comprising at least one oligonucleotide according to  claim 5 .