Compositions and methods for the therapy and diagnosis of breast cancer

Abstract

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

1 . An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
 (a) the amino acid sequence set forth in SEQ ID NO:469;   (b) the amino acid sequence encoded by the polynucleotide of SEQ ID NO:469;   (c) amino acid sequences having at least 70% identity to the sequence set forth in SEQ ID NO:469; and   (d) amino acid sequences having at least 90% identity to the sequence set forth in SEQ ID NO:469.   
     
     
         2 . A fusion protein comprising at least one polypeptide according to  claim 1 . 
     
     
         3 . A composition comprising a first component selected from the group consisting of physiologically acceptable carriers and immunostimulants, and a second component comprising a polypeptide according to  claim 1 .