Hydrogenation of imine intermediates of sertraline with catalysts

Abstract

Provided are hydrogenation processes of sertraline imine intermediates with catalysts in various reactors.

1 . A process for preparing a cobalt catalyst suitable for reduction of sertraline-1-imine comprising the steps of:
 a) calcining an alumina-silica support;   b) evaporating moisture from the calcined support;   c) contacting the calcined support with an aqueous solution of cobalt nitrate to saturate the surface of the support to obtain a catalyst;   d) drying the catalyst; and   e) calcining the catalyst in the presence of hydrogen to obtain an oxidation state of CoO.   
     
     
         2 . The process of  claim 1 , wherein the calcining is carried out by heating to a temperature of at least about 450° C. 
     
     
         3 . The process of  claim 2 , wherein the temperature is about 500° C. 
     
     
         4 . The process of  claim 1 , wherein evaporating is carried out under reduced pressure. 
     
     
         5 . The process of  claim 1 , wherein the drying is carried out of about 100° C. to about 140° C. 
     
     
         6 . The process of  claim 5 , wherein the temperature is about 120° C. 
     
     
         7 . The process of  claim 1 , wherein the hydrogen is added to a reactor at a rate of about GHSV 2000 h −1  to about 3000 h −1 . 
     
     
         8 . The process of  claim 7 , wherein the hydrogen is added at a rate of about GHSV 2500 per hour. 
     
     
         9 . The catalyst prepared by the process of  claim 1 .