Antimicrobial compositions containing colloids of oligodynamic metals

Abstract

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active ions in the compositions due to the different water solubilities of the ions, allowing antimicrobial release profiles to be tailored for a given application and providing for sustained antimicrobial activity over time. More particularly, the invention relates to polymer compositions containing colloids comprised of salts of one or more oligodynamic metal, such as silver. The process of the invention includes mixing a solution of one or more oligodynamic metal salts with a polymer solution or dispersion and precipitating a colloid of the salts by addition of other salts to the solution which react with some or all of the first metal salts. The compositions can be incorporated into articles or can be employed as a coating on articles such as medical devices. Coatings may be on all or part of a surface.

1 - 24 . (canceled) 
     
     
         25 . A composition comprising a polyurethane, polyurethane-urea-silane copolymer other than the polyurethane, and at least one oligodynamic metal compound. 
     
     
         26 . The composition of  claim 25  wherein the polyurethane is chosen from polyether polyurethanes, polyester polyurethanes, polyurethaneureas, or their copolymers. 
     
     
         27 . The composition of  claim 25  wherein the polyurethane-urea-silane copolymer has 7-12% by weight silane based on the weight of the entire copolymer. 
     
     
         28 . The composition of  claim 25  wherein the oligodynamic metal compound includes at least one oligodynamic metal compound in colloid form. 
     
     
         29 . The composition of  claim 28  wherein the oligodynamic metal compound in colloid form comprises colloidal silver chloride. 
     
     
         30 . The composition of  claim 29  further comprising an oligodynamic metal compound comprising silver nitrate. 
     
     
         31 . The composition of  claim 26  wherein the polyurethane-urea-silane copolymer has 7-12% by weight silane based on the weight of the entire copolymer, and the oligodynamic metal compound comprises silver nitrate and colloidal silver chloride.