Methods for Affecting Body Composition

Abstract

Methods for affecting body composition include the use of amylin or amylin agonist(s). Total body weight may be reduced, maintained or even increased; however, the body fat is reduced or body fat gain is prevented, while lean body mass is maintained or increased.

1 . A method for reducing body fat or body fat gain in a subject while maintaining or increasing lean body mass, the method comprising administering to the subject an amylin agonist, wherein the amylin agonist has at least 80% identity to any of SEQ ID NOs: 1 through 28, wherein the subject is in need of treatment, thereby reducing body fat or body fat gain while maintaining or increasing lean body mass. 
     
     
         2 . The method of  claim 1  wherein body weight is reduced. 
     
     
         3 . The method of  claim 1  wherein body weight is maintained or increased. 
     
     
         4 . The method of  claim 1  wherein the subject is a mammal. 
     
     
         5 . The method of  claim 4  wherein the mammal is a human. 
     
     
         6 . The method of  claim 5  wherein the human is overweight or obese. 
     
     
         7 . The method of  claim 4  wherein the mammal is selected from a group consisting of a chicken, a pig, a cow, a steer, a horse, a sheep, and a goat. 
     
     
         8 . The method of  claim 1  wherein the amylin agonist has at least 90% identity to any one of SEQ ID NOs: 1 through 28, or an analog or fragment thereof. 
     
     
         9 . The method of  claim 1  wherein the amylin agonist has at least 95% identity to any one of SEQ ID NOs: 1 through 28. 
     
     
         10 . The method of  claim 1  wherein the-amylin agonist is administered parenterally. 
     
     
         11 . The method of  claim 1  wherein the body fat and lean body mass is percent body fat and percent lean body mass, respectively. 
     
     
         12 . A method of altering a body composition of a subject, wherein body fat is reduced and lean body mass is maintained or increased, comprising administering an amylin agonist to the subject, wherein the amylin agonist has at least 80% identity to any one of SEQ ID NOs: 1 through 28, thereby altering the body composition of the subject. 
     
     
         13 . The method of  claim 12  wherein the subject is overweight or obese. 
     
     
         14 . The method of  claim 12  wherein the amylin agonist has at least 90% identity to any one of SEQ ID NOs: 1 through 28 or an analog or fragment thereof. 
     
     
         15 . The method of  claim 12  wherein the amylin agonist has at least 95% identity to any one of SEQ ID NOs: 1 through 28. 
     
     
         16 . The method of  claim 12  wherein the amylin agonist is administered parenterally. 
     
     
         17 . The method of  claim 12  wherein body weight is reduced. 
     
     
         18 . The method of  claim 12  wherein body weight is maintained or increased. 
     
     
         19 . The method of  claim 12  wherein the body fat and lean body mass is percent body fat and percent lean body mass, respectively. 
     
     
         20 . The method of  claim 1  further comprising dieting.