Vector system

Abstract

The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.

1 . A method for delivery of an antibody for treating a non-cancerous disease in a subject, said method comprising directly administering to a cell in the subject a lentiviral vector comprising a nucleotide sequence encoding an antibody, wherein the antibody is expressed in the cell, thereby stimulating an immune response and treating the non-cancerous disease in the subject. 
     
     
         2 . The method of  claim 1 , wherein the non-cancerous disease is an immune system disease, a cardiovascular disease, an infectious disease, an eye disease, or a neurological disorder. 
     
     
         3 . The method of  claim 1 , wherein the antibody is humanized. 
     
     
         4 . The method of  claim 1 , wherein the antibody is a monoclonal antibody. 
     
     
         5 . The method of  claim 1 , wherein the antibody is a single chain antibody. 
     
     
         6 . The method of  claim 1 , wherein the antibody is a human antibody.