US2008171390A1PendingUtilityA1

Adenovirus vectors containing cell status-specific response elements and methods of use thereof

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Assignee: CELL GENESYS INCPriority: Sep 10, 1998Filed: Oct 25, 2007Published: Jul 17, 2008
Est. expirySep 10, 2018(expired)· nominal 20-yr term from priority
Inventors:De-Chao YuDaniel R. Henderson
C12N 2710/10345C12N 15/86C12N 2710/10343C12N 2830/008A61K 48/0058C12N 2830/007A61K 35/13A61P 35/00C12N 2830/002
68
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Claims

Abstract

The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

Claims

exact text as granted — not AI-modified
1 - 25 . (canceled) 
     
     
         26 . A method of propagating adenovirus specific for cells which allow a cell status-specific TRE to function, said method comprising combining an adenovirus vector comprising an adenovirus gene under transcriptional control of a transcriptional regulatory element (TRE) comprising a cell status-specific TRE with the cells, whereby said adenovirus is propagated. 
     
     
         27 - 28 . (canceled)

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