Cartridge Containing a Medicament Suspension and Mixing Elements Having Different Densities

Abstract

The present invention relates to a device for storage and administration of a medicament suspension comprising a container ( 1 ) for receiving a medicament suspension wherein the container has two mixing elements ( 5, 6 ) which differ with respect to their density such that the first mixing element ( 5 ) has a density significantly above the background liquid and significantly above the fully mixed suspension density and the second mixing element ( 6 ) has a density significantly below the background liquid and significantly below the fully mixed suspension density.

1 . A device for storage and administration of a medicament suspension comprising
 a container containing a medicament suspension which suspension comprises a background liquid with suspended particulate,   wherein the container comprises two mixing elements which differ in density such that a first mixing element has a density significantly above the density of the background liquid, and significantly above the fully mixed suspension density, and   a second mixing element has a density significantly below the density of the background liquid, and significantly below the fully mixed suspension density.   
     
     
         2 . The device according to  claim 1 , wherein the container for receiving the medicament is a cylindrical cartridge which is sealed at the top by a movable plunger and at the bottom by an outlet port. 
     
     
         3 . The device according to  claim 1 , wherein the mixing elements are inert to the medicament suspension. 
     
     
         4 . The device according to  claim 1 , wherein the first mixing element and/or the second mixing element is a hollow sphere. 
     
     
         5 . The device according to  claim 1 , wherein the first mixing element and/or the second mixing element is a glass or plastic sphere. 
     
     
         6 . The device according to  claim 1 , wherein the density of the first mixing element and of the second mixing element depends on the viscosity of the suspension. 
     
     
         7 . The device according to  claim 1 , wherein the first and second mixing elements are of the same diameter. 
     
     
         8 . The device according to  claim 1 , wherein the first and second mixing elements are of different diameter. 
     
     
         9 . The device according to  claim 1 , wherein the first mixing element and the second mixing element are of the same shape. 
     
     
         10 . The device according to  claim 1 , wherein the first mixing element and the second mixing element are of different shape. 
     
     
         11 . The device according to  claim 2 , wherein the mixing elements are inert to the medicament suspension. 
     
     
         12 . The device according to anyone of the  claims 2 , wherein the density of the first mixing element and of the second mixing element depends on the viscosity of the suspension. 
     
     
         13 . The device according to anyone of the  claims 3 , wherein the density of the first mixing element and of the second mixing element depends on the viscosity of the suspension. 
     
     
         14 . The device according to anyone of the  claims 4 , wherein the density of the first mixing element and of the second mixing element depends on the viscosity of the suspension. 
     
     
         15 . The device according to anyone of the  claims 5 , wherein the density of the first mixing element and of the second mixing element depends on the viscosity of the suspension.