US2008161607A1PendingUtilityA1

Processes for preparation of polymorphic form II of sertraline hydrochloride

Assignee: TEVA PHARMAPriority: Apr 29, 2002Filed: Mar 5, 2008Published: Jul 3, 2008

Est. expiryApr 29, 2022(expired)· nominal 20-yr term from priority

Inventors:Ronen Borochovitch Marioara Mendelovici Tamar Nidam Ruth Tenengauzer Julia Hrakovsky Judith Aronhime

C07C 2602/10C07C 209/84

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Claims

Abstract

Provided are processes for preparation of crystalline sertraline hydrochloride Form II substantially free of other polymorphic forms of sertraline hydrochloride, preferably on an industrial scale.

Claims

exact text as granted — not AI-modified

1 . A process for the preparation of sertraline hydrochloride polymorphic form II, wherein a solution of sertraline free amine is seeded with some crystals of polymorphic form II and hydrogen chloride gas is added. 
     
     
         2 . The process of claim  40 , wherein the solution of sertraline free amine is seeded with some crystals of polymorphic form II and subsequently hydrogen chloride gas is added. 
     
     
         3 . The process of claim  40 , wherein hydrogen chloride gas is added to the solution of sertraline free amine and subsequently the solution is seeded with some crystals of polymorphic form II.

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