US2008161325A1PendingUtilityA1
1, 3, Diamino-2-Hydroxypropane Pro-Drug Derivatives
Est. expirySep 6, 2022(expired)· nominal 20-yr term from priority
A61P 43/00A61P 9/00C07C 237/22C07D 241/24C07D 295/185C07D 401/04C07C 2601/14C07D 213/30A61P 25/02C07D 319/06C07C 317/50C07D 207/16C07D 333/48C07C 2601/08C07C 317/48C07D 207/12C07D 277/30C07C 271/22C07C 311/09C07D 261/18C07D 211/96C07D 333/32C07D 307/20C07D 277/56C07D 309/12C07D 237/04C07D 231/14C07D 207/26C07C 317/44A61P 25/16A61P 25/28C07D 209/08C07C 237/06C07D 213/81C07D 233/90C07C 255/29C07D 317/30C07D 213/82C07C 233/65C07C 323/60A61P 25/00C07C 2601/02C07D 263/32C07D 211/62C07C 215/14C07C 215/18A61K 31/00
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Claims
Abstract
The present invention relates to compounds of formula (AA) (I) and (X): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
Claims
exact text as granted — not AI-modified1 . A compound of formula:
or a pharmaceutically acceptable salt thereof, wherein one of R N and R N ′ is hydrogen and
the other is —C(═O)—(CRR′) 0-6 R 100 , —C(═O)—(CRR′) 1-6 —O—R′ 100 , —C(═O)—(CRR′) 1-6 —S—R′ 100 , —C(═O)—(CRR′) 1-6 —C(═O)—R 100 , —C(═O)—(CRR′) 1-6 —SO 2 —R 100 , —C(═O)—(CRR′) 1-6 —NR 100 —R′ 100 , or
wherein
R 4 is selected from the group consisting of H; NH 2 ; —NH—(CH 2 ) n6 —R 4-1 ; —NHR 8 ; —NR 50 C(O)R 5 ; C 1 -C 4 alkyl-NHC(O)R 5 ; —(CH 2 ) 0-4 R 8 ; —O—C 1 -C 4 alkanoyl; OH; C 6 -C 10 aryloxy optionally substituted with 1, 2, or 3 groups that are independently halogen, C 1 -C 4 alkyl, —CO 2 H, —C(O)—C 1 -C 4 alkoxy, or C 1 -C 4 alkoxy; C 1 -C 6 alkoxy; aryl C 1 -C 4 alkoxy; —NR 50 CO 2 R 51 ; —C 1 -C 4 alkyl-NR 50 CO 2 R 51 ; —C≡N; —CF 3 ; —CF 2 —CF 3 ; —C≡CH; —CH 2 —CH═CH 2 ; —(CH 2 ) 1-4 —R 4-1 ; —(CH 2 ) 1-4 —NH—R 4-1 ; —O—(CH 2 ) n6 —R 4-1 ; —S—(CH 2 ) n6 —R 4-1 ; —(CH 2 ) 0-4 —NHC(O)—(CH 2 ) 0-6 —R 52 ; —(CH 2 ) 0-4 —R 53 —(CH 2 ) 0-4 —R 54 ;
wherein
n 6 is 0, 1, 2, or 3;
n 7 is 0, 1, 2, or 3;
R 4-1 is selected from the group consisting of —SO 2 —(C 1 -C 8 alkyl), —SO—(C 1 -C 8 alkyl), —S—(C 1 -C 8 alkyl), —S—CO—(C 1 -C 6 alkyl), —SO 2 —NR 4-2 R 4-3 ; —CO—C 1 -C 2 alkyl; —CO—NR 4-3 R 4-4 ;
R 4-2 and R 4-3 are independently H, C 1 -C 3 alkyl, or C 3 -C 6 cycloalkyl;
R 4-4 is alkyl, arylalkyl, alkanoyl, or arylalkanoyl;
R 4-6 is —H or C 1 -C 6 alkyl;
R 5 is selected from the group consisting of C 3 -C 7 cycloalkyl; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, —NR 6 R 7 , C 1 -C 4 alkoxy, C 5 -C 6 heterocycloalkyl, C 5 -C 6 heteroaryl, C 6 -C 10 aryl, C 3 -C 7 cycloalkyl C 1 -C 4 alkyl, —S—C 1 -C 4 alkyl, —SO 2 —C 1 -C 4 alkyl, —CO 2 H, —CONR 6 R 7 , —CO 2 —C 1 -C 4 alkyl, C 6 -C 10 aryloxy; heteroaryl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 1 -C 4 haloalkyl, or OH; heterocycloalkyl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, or C 2 -C 4 alkanoyl; aryl optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 haloalkyl; and —NR 6 R 7 ; wherein
R 6 and R 7 are independently selected from the group consisting of H, C 1 -C 6 alkyl, C 2 -C 6 alkanoyl, phenyl, —SO 2 —C 1 -C 4 alkyl, phenyl C 1 -C 4 alkyl;
R 8 is selected from the group consisting of —SO 2 -heteroaryl, —SO 2 -aryl, —SO 2 -heterocycloalkyl, —SO 2 —C 1 -C 10 alkyl, —C(O)NHR 9 , heterocycloalkyl, —S—C 1 -C 6 alkyl, —S—C 2 -C 4 alkanoyl, wherein
R 9 is aryl C 1 -C 4 alkyl, C 1 -C 6 alkyl, or H; R 50 is H or C 1 -C 6 alkyl;
R 51 is selected from the group consisting of aryl C 1 -C 4 alkyl; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, cyano, heteroaryl, —NR 6 R 7 , —C(O)NR 6 R 7 , C 3 -C 7 cycloalkyl, or —C 1 -C 4 alkoxy; heterocycloalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 2 -C 4 alkanoyl, aryl C 1 -C 4 alkyl, and —SO 2 C 1 -C 4 alkyl; alkenyl; alkynyl; heteroaryl optionally substituted with 1, 2, or 3 groups that are independently OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl); heteroarylalkyl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl); aryl; heterocycloalkyl; C 3 -C 8 cycloalkyl; and cycloalkylalkyl; wherein the aryl; heterocycloalkyl, C 3 -C 8 cycloalkyl, and cycloalkylalkyl groups are optionally substituted with 1, 2, 3, 4 or 5 groups that are independently halogen, CN, NO 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkanoyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxy, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 1 -C 6 thioalkoxy, C 1 -C 6 thioalkoxy C 1 -C 6 alkyl, or C 1 -C 6 alkoxy C 1 -C 6 alkoxy;
R 52 is heterocycloalkyl, heteroaryl, aryl, cycloalkyl, —S(O) 0-2 —C 1 -C 6 alkyl, CO 2 H, —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —CO 2 -alkyl, —NHS(O) 0-2 —C 1 -C 6 alkyl, —N (alkyl)S(O) 0-2 —C 1 -C 6 alkyl, —S(O) 0-2 -heteroaryl, —S(O) 0-2 -aryl, —NH(arylalkyl), —N(alkyl)(arylalkyl), thioalkoxy, or alkoxy, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently alkyl, alkoxy, thioalkoxy, halogen, haloalkyl, haloalkoxy, alkanoyl, NO 2 , CN, alkoxycarbonyl, or aminocarbonyl;
R 53 is absent, —O—, —C(O)—, —NH—, —N(alkyl)-, —NH—S(O) 0-2 —, —N (alkyl)-S(O) 0-2 —, —S(O) 0-2 —NH—, —S(O) 0-2 —N(alkyl)-, —NH—C(S)—, or —N(alkyl)-C(S)—;
R 54 is heteroaryl, aryl, arylalkyl, heterocycloalkyl, CO 2 H, —CO 2 -alkyl, —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —C(O)NH 2 , C 1 -C 8 alkyl, OH, aryloxy, alkoxy, arylalkoxy, NH 2 , NH(alkyl), N(alkyl)(alkyl), or —C 1 -C 6 alkyl-CO 2 —C 1 -C 6 alkyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently alkyl, alkoxy, CO 2 H, —CO 2 -alkyl, thioalkoxy, halogen, haloalkyl, haloalkoxy, hydroxyalkyl, alkanoyl, NO 2 , CN, alkoxycarbonyl, or aminocarbonyl;
X is selected from the group consisting of —C 1 -C 6 alkylidenyl optionally substituted with 1, 2, or 3 methyl groups; and —NR 4-6 —; or
R 4 and R 4-6 combine to form —(CH 2 ) n10 —, wherein
n 10 is 1, 2, 3, or 4;
Z is selected from the group consisting of a bond; SO 2 ; SO; S; and C(O);
Y is selected from the group consisting of H; C 1 -C 4 haloalkyl; C 5 -C 6 heterocycloalkyl; C 6 -C 10 aryl; OH; —N(Y 1 )(Y 2 ); C 1 -C 10 alkyl optionally substituted with 1 thru 3 substituents which can be the same or different and are selected from the group consisting of halogen, hydroxy, alkoxy, thioalkoxy, and haloalkoxy; C 3 -C 8 cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from C 1 -C 3 alkyl, and halogen; alkoxy; aryl optionally substituted with halogen, alkyl, alkoxy, CN or NO 2 ; arylalkyl optionally substituted with halogen, alkyl, alkoxy, CN or NO 2 ; wherein
Y 1 and Y 2 are the same or different and are H; C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 substituents selected from the group consisting of halogen, C 1 -C 4 alkoxy, C 3 -C 8 cycloalkyl, and OH; C 2 -C 6 alkenyl; C 2 -C 6 alkanoyl; phenyl; —SO 2 —C 1 -C 4 alkyl; phenyl C 1 -C 4 alkyl; or C 3 -C 8 cycloalkyl C 1 -C 4 alkyl; or
Y 1 , Y 2 and the nitrogen to which they are attached form a ring selected from the group consisting of piperazinyl, piperidinyl, morpholinyl, and pyrrolidinyl, wherein each ring is optionally substituted with 1, 2, 3, or 4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxy C 1 -C 6 alkyl, or halogen;
R 1 is —(CH 2 ) 1-2 —S(O) 0-2 —(C 1 -C 6 alkyl), or
C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, ═O, —SH, —C≡N, —CF 3 , —C 1 -C 3 alkoxy, amino, mono- or dialkylamino, —N(R)C(O)R′—, —OC(═O)-amino and —OC(═O)-mono- or dialkylamino, or
C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, each of which is optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, amino, and mono- or dialkylamino, or
aryl, heteroaryl, heterocyclyl, —C 1 -C 6 alkyl-aryl, —C 1 -C 6 alkyl-heteroaryl, or —C 1 -C 6 alkyl-heterocyclyl, where the ring portions of each are optionally substituted with 1, 2, 3, or 4 groups independently selected from halogen, —OH, —SH, —C≡N, —NR 105 R′ 105 , —CO 2 R, —N(R)COR′, or —N(R)SO 2 R′, —C(═O)—(C 1 -C 4 )alkyl, —SO 2 -amino, —SO 2 -mono or dialkylamino, —C(═O)-amino, —C(═O)-mono or dialkylamino, —SO 2 —(C 1 -C 4 )alkyl, or
—C 1 -C 6 alkoxy optionally substituted with 1, 2, or 3 groups which are independently a halogen, or
C 3 -C 7 cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, amino, —C 1 -C 6 alkyl and mono- or dialkylamino, or
C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF 3 , —C 1 -C 3 alkoxy, amino, mono- or dialkylamino and —C 1 -C 3 alkyl, or
C 2 -C 10 alkenyl or C 2 -C 10 alkynyl each of which is optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, amino, C 1 -C 6 alkyl and mono- or dialkylamino; and
the heterocyclyl group is optionally further substituted with oxo;
R and R′ independently are hydrogen or C 1 -C 10 alkyl;
R 2 is selected from the group consisting of H; C 1 -C 6 alkyl, optionally substituted with 1, 2, or 3 substituents that are independently selected from the group consisting of C 1 -C 3 alkyl, halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, and —NR 1-a R 1-b ; wherein R 1-a and R 1-b are —H or C 1 -C 6 alkyl;
—(CH 2 ) 0-4 -aryl; —(CH 2 ) 0-4 -heteroaryl; C 2 -C 6 alkenyl; C 2 -C 6 alkynyl; —CONR N-2 R N-3 ; —SO 2 NR N-2 R N-3 ; —CO 2 H; and —CO 2 —(C 1 -C 4 alkyl);
R 3 is selected from the group consisting of H; C 1 -C 6 alkyl, optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C 1 -C 3 alkyl, halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, and —NR 1-a R 1-b ; —(CH 2 ) 0-4 -aryl; —(CH 2 ) 0-4 -heteroaryl; C 2 -C 6 alkenyl; C 2 -C 6 alkynyl; —CO—NR N-2 R N-3 ; —SO 2 —NR N-2 R N-3 ; —CO 2 H; and —CO—O—(C 1 -C 4 alkyl);
or
R 2 , R 3 and the carbon to which they are attached form a carbocycle of three thru seven carbon atoms, wherein one carbon atom is optionally replaced by a group selected from —O—, —S—, —SO 2 —, or —NR N-2 —;
R C is selected from the group consisting of C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from the group consisting of R 205 , —OC═ONR 235 R 240 , —S(═O) 0-2 (C 1 -C 6 alkyl), —SH, —NR 235 C═ONR 235 R 240 , —C═ONR 235 R 240 , and —S(═O) 2 NR 235 R 240 ; —(CH 2 ) 0-3 —(C 3 -C 8 )cycloalkyl wherein the cycloalkyl is optionally substituted with 1, 2, or 3 groups independently selected from the group consisting of R 205 , —CO 2 H, and —CO 2 —(C 1 -C 4 alkyl); —(CR 245 R 250 ) 0-4 -aryl; —(CR 245 R 250 ) 0-4 -heteroaryl; —(CR 245 R 250 ) 0-4 -heterocycloalkyl; —(CR 245 R 250 ) 0-4 -aryl-heteroaryl; —(CR 245 R 250 ) 0-4 -aryl-heterocycloalkyl; —(CR 245 R 250 ) 0-4 -aryl-aryl; —(CR 245 R 250 ) 0-4 -heteroaryl-aryl; —(CR 245 R 250 ) 0-4 -heteroaryl-heterocycloalkyl; —(CR 245 R 250 ) 0-4 -heteroaryl-heteroaryl; —(CR 245 R 250 ) 0-4 -heterocycloalkyl-heteroaryl; —(CR 245 R 250 ) 0-4 -heterocycloalkyl-heterocycloalkyl; —(CR 245 R 250 ) 0-4 -heterocycloalkyl-aryl; —[C(R 255 )(R 260 )] 1-3 —CO—N—(R 255 ) 2 ; —CH(aryl) 2 ; —CH(heteroaryl) 2 ; —CH(heterocycloalkyl) 2 ; —CH(aryl)(heteroaryl); cyclopentyl, cyclohexyl, or cycloheptyl ring fused to aryl, heteroaryl, or heterocycloalkyl wherein one carbon of the cyclopentyl, cyclohexyl, or cycloheptyl is optionally replaced with NH, NR 215 , O, or S(═O) 0-2 , and wherein the cyclopentyl, cyclohexyl, or cycloheptyl group can be optionally substituted with 1 or 2 groups that are independently R 205 or ═O; —CO—NR 235 R 240 ; —SO 2 —(C 1 -C 4 alkyl); C 2 -C 10 alkenyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 10 alkynyl optionally substituted with 1, 2, or 3 R 205 groups; —(CH 2 ) 0-1 —CH((CH 2 ) 0-6 —OH)—(CH 2 ) 0-1 -aryl; —(CH 2 ) 0-1 —CHR C-6 —(CH 2 ) 0-1 -heteroaryl; —CH(-aryl or -heteroaryl)-CO—O(C 1 -C 4 alkyl); —CH(—CH 2 —OH)—CH(OH)-phenyl-NO 2 ; (C 1 -C 6 alkyl)-O—(C 1 -C 6 alkyl)-OH; —CH 2 —NH—CH 2 —CH(—O—CH 2 —CH 3 ) 2 ; —H; and —(CH 2 ) 0-6 —C(═NR 235 )(NR 235 R 240 ); wherein
each aryl is optionally substituted with 1, 2, or 3 R 200 ;
each heteroaryl is optionally substituted with 1, 2, 3, or 4 R 200 ;
each heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 R 210 ;
R 200 at each occurrence is independently selected from the group consisting of C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 R 205 groups; OH; —NO 2 ; halogen; —CO 2 H; C≡N; —(CH 2 ) 0-4 —CO—NR 220 R 225 ; —(CH 2 ) 0-4 —CO—(C 1 -C 12 alkyl); —(CH 2 ) 0-4 —CO—(C 2 -C 12 alkenyl); —(CH 2 ) 0-4 —CO—(C 2 -C 12 alkynyl); —(CH 2 ) 0-4 —CO—(C 3 -C 7 cycloalkyl); —(CH 2 ) 0-4 —CO-aryl; —(CH 2 ) 0-4 —CO-heteroaryl; —(CH 2 ) 0-4 —CO-heterocycloalkyl; —(CH 2 ) 0-4 —CO 2 R 215 ; —(CH 2 ) 0-4 —SO 2 —NR 220 R 225 ; —(CH 2 ) 0-4 —SO—(C 1 -C 8 alkyl); —(CH 2 ) 0-4 —SO 2 —(C 1 -C 12 alkyl); —(CH 2 ) 0-4 —SO 2 —(C 3 -C 7 cycloalkyl); —(CH 2 ) 0-4 —N(H or R 215 )—CO 2 R 215 ; —(CH 2 ) 0-4 —N(H or R 215 )—CO—N(R 215 ) 2 ; —(CH 2 ) 0-4 —N—CS—N(R 215 ) 2 ; —(CH 2 ) 0-4 —N(—H or R 215 )—CO—R 220 ; —(CH 2 ) 0-4 —NR 220 R 225 ; —(CH 2 ) 0-4 —O—CO—(C 1 -C 6 alkyl); —(CH 2 ) 0-4 —O—P(O)—(OR 240 ) 2 ; —(CH 2 ) 0-4 —O—CO—N(R 215 ) 2 ; —(CH 2 ) 0-4 —O—CS—N(R 215 ) 2 ; —(CH 2 ) 0-4 —O—(R 215 ) 2 ; —(CH 2 ) 0-4 —O—(R 215 ) 2 —COOH; —(CH 2 ) 0-4 —S—(R 215 ) 2 ; —(CH 2 ) 0-4 —O—(C 1 -C 6 alkyl optionally substituted with 1, 2, 3, or 5 —F); C 3 -C 7 cycloalkyl; C 2 -C 6 alkenyl optionally substituted with 1 or 2 R 205 groups; C 2 -C 6 alkynyl optionally substituted with 1 or 2 R 205 groups; —(CH 2 ) 0-4 —N(H or R 215 )—SO 2 —R 220 ; and —(CH 2 ) 0-4 —C 3 -C 7 cycloalkyl;
wherein each aryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R 205 , R 210 or C 1 -C 6 alkyl substituted with 1, 2, or 3 groups that are independently R 205 or R 210 ;
wherein each heterocycloalkyl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R 210 ;
wherein each heteroaryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R 205 , R 210 , or C 1 -C 6 alkyl substituted with 1, 2, or 3 groups that are independently R 205 or R 210 ;
R 205 at each occurrence is independently selected from the group consisting of C 1 -C 6 alkyl, halogen, —OH, —O-phenyl, —SH, —C≡N, —CF 3 , C 1 -C 6 alkoxy, NH 2 , NH(C 1 -C 6 alkyl), and N—(C 1 -C 6 alkyl)(C 1 -C 6 alkyl);
R 210 at each occurrence is independently selected from the group consisting of C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 6 alkenyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 6 alkynyl optionally substituted with 1, 2, or 3 R 205 groups; halogen; C 1 -C 6 alkoxy; C 1 -C 6 haloalkoxy; —NR 220 R 225 ; OH; C≡N; C 3 -C 7 cycloalkyl optionally substituted with 1, 2, or 3 R 205 groups; —CO—(C 1 -C 4 alkyl); —SO 2 —NR 235 R 240 ; —CO—NR 235 R 240 ; —SO 2 —(C 1 -C 4 alkyl); and ═O; wherein
R 215 at each occurrence is independently selected from the group consisting of C 1 -C 6 alkyl, —(CH 2 ) 0-2 -(aryl), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, and —(CH 2 ) 0-2 -(heteroaryl), —(CH 2 ) 0-2 -(heterocycloalkyl); wherein the aryl group at each occurrence is optionally substituted with 1, 2, or 3 groups that are independently R 205 or R 210 ; wherein the heterocycloalkyl group at each occurrence is optionally substituted with 1, 2, or 3 R 210 ; wherein each heteroaryl group at each occurrence is optionally substituted with 1, 2, or 3 R 210 ;
R 220 and R 225 at each occurrence are independently selected from the group consisting of —H, —C 1 -C 6 alkyl, hydroxy C 1 -C 6 alkyl, amino C 1 -C 6 alkyl; halo C 1 -C 6 alkyl; —C 3 -C 7 cycloalkyl, —(C 1 -C 2 alkyl)-(C 3 -C 7 cycloalkyl), —(C 1 -C 6 alkyl)-O—(C 1 -C 3 alkyl), —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —C 1 -C 6 alkyl chain with one double bond and one triple bond, -aryl, -heteroaryl, and heterocycloalkyl; wherein the aryl group at each occurrence is optionally substituted with 1, 2, or 3 R 270 groups, wherein
R 270 at each occurrence is independently R 205 , C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 6 alkenyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 6 alkynyl optionally substituted with 1, 2, or 3 R 205 groups; halogen; C 1 -C 6 alkoxy; C 1 -C 6 haloalkoxy; NR 235 R 240 ; OH; C≡N; C 3 -C 7 cycloalkyl optionally substituted with 1, 2, or 3 R 205 groups; —CO—(C 1 -C 4 alkyl); —SO 2 —NR 235 R 240 ; —CO—NR 235 R 240 ; —SO 2 —(C 1 -C 4 alkyl); and ═O; wherein the heterocycloalkyl group at each occurrence is optionally substituted with 1, 2, or 3 R 205 groups; wherein each heteroaryl group at each occurrence is optionally substituted with 1, 2, or 3 R 205 groups;
R 235 and R 240 at each occurrence are independently H, or C 1 -C 6 alkyl;
R 245 and R 250 at each occurrence are independently selected from the group consisting of H, C 1 -C 4 alkyl, C 1 -C 4 hydroxyalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, —(CH 2 ) 0-4 —C 3 -C 7 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, aryl C 1 -C 4 alkyl, heteroaryl C 1 -C 4 alkyl, and phenyl; or
R 245 and R 250 are taken together with the carbon to which they are attached to form a carbocycle of 3, 4, 5, 6, or 7 carbon atoms, optionally where one carbon atom is replaced by a heteroatom selected from the group consisting of —O—, —S—, —SO 2 —, and —NR 220 —;
R 255 and R 260 at each occurrence are independently selected from the group consisting of H; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 6 alkenyl optionally substituted with 1, 2, or 3 R 205 groups; C 2 -C 6 alkynyl optionally substituted with 1, 2, or 3 R 205 groups; —(CH 2 ) 1-2 —S(O) 0-2 —(C 1 -C 6 alkyl); —(CH 2 ) 0-4 —C 3 -C 7 cycloalkyl optionally substituted with 1, 2, or 3 R 205 groups; —(C 1 -C 4 alkyl)-aryl; —(C 1 -C 4 alkyl)-heteroaryl; —(C 1 -C 4 alkyl)-heterocycloalkyl; -aryl; -heteroaryl; -heterocycloalkyl; (CH 2 ) 1-4 —R 265 —(CH 2 ) 0-4 -aryl; —(CH 2 ) 1-4 —R 265 —(CH 2 ) 0-4 -heteroaryl; and; —(CH 2 ) 1-4 —R 265 —(CH 2 ) 0-4 -heterocycloalkyl; wherein
R 265 at each occurrence is independently —O—, —S— or —N(C 1 -C 6 alkyl)-;
each aryl or phenyl is optionally substituted with 1, 2, or 3 groups that are independently R 205 , R 210 , or C 1 -C 6 alkyl substituted with 1, 2, or 3 groups that are independently R 205 or R 210 ;
each heteroaryl is optionally substituted with 1, 2, 3, or 4 R 200 , each heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 R 210 ;
R 100 and R′ 100 independently represent aryl, heteroaryl, heterocyclyl, -aryl-W-aryl, -aryl-W-heteroaryl, -aryl-W-heterocyclyl, -heteroaryl-W-aryl, -heteroaryl-W-heteroaryl, -heteroaryl-W-heterocyclyl, -heterocyclyl-W-aryl, -heterocyclyl-W-heteroaryl, -heterocyclyl-W-heterocyclyl, —CH[(CH 2 ) 0-2 —O—R 150 ]—(CH 2 ) 0-2 -aryl, —CH[(CH 2 ) 0-2 —O—R 150 ]—(CH 2 ) 0-2 -heterocyclyl or —CH[(CH 2 ) 0-2 —O—R 150 ]—(CH 2 ) 0-2 -heteroaryl, where the ring portions of each are optionally substituted with 1, 2, or 3 groups independently selected from
—OR, —NO 2 , C 1 -C 6 alkyl, halogen, —C≡N, —OCF 3 , —CF 3 , —(CH 2 ) 0-4 —O—P(═O)(OR)(OR′), —(CH 2 ) 0-4 —CO—NR 105 R′ 105 , —(CH 2 ) 0-4 —O— (CH 2 ) 0-4 —CONR 102 R 102 ′, —(CH 2 ) 0-4 —CO—(C 1 -C 12 alkyl), —(CH 2 ) 0-4 —CO—(C 2 -C 12 alkenyl), —(CH 2 ) 0-4 —CO—(C 2 -C 12 alkynyl), —(CH 2 ) 0-4 —CO—(CH 2 ) 0-4 (C 3 -C 7 cycloalkyl), —(CH 2 ) 0-4 —R 110 , —(CH 2 ) 0-4 —R 120 , —(CH 2 ) 0-4 —R 130 , —(CH 2 ) 0-4 —CO—R 110 , —(CH 2 ) 0-4 —CO—R 120 , —(CH 2 ) 0-4 —CO—R 130 , —(CH 2 ) 0-4 —CO—R 140 , —(CH 2 ) 0-4 —CO—O—R 150 , —(CH 2 ) 0-4 —SO 2 —NR 105 R′ 105 , —(CH 2 ) 0-4 —SO—(C 1 -C 8 alkyl), —(CH 2 ) 0-4 —SO 2 (C 1 -C 12 alkyl), —(CH 2 ) 0-4 —SO 2 —(CH 2 ) 0-4 —(C 3 -C 7 cycloalkyl), —(CH 2 ) 0-4 —N(R 150 )—CO—O—R 150 , —(CH 2 ) 0-4 —N(R 150 )—CO—N(R 150 ) 2 , —(CH 2 ) 0-4 —N(R 150 )—CS—N(R 150 ) 2 , —(CH 2 ) 0-4 —N(R 150 )—CO—R 105 , —(CH 2 ) 0-4 —NR 105 R′ 105 , —(CH 2 ) 0-4 —R 140 , —(CH 2 ) 0-4 —O—CO—(C 1 -C 6 alkyl), —(CH 2 ) 0-4 —O—P(O)—(O—R 110 ) 2 , —(CH 2 ) 0-4 —O—CO—N(R 150 ) 2 , —(CH 2 ) 0-4 —O—CS—N(R 150 ) 2 , —(CH 2 ) 0-4 —O—(R 150 ), —(CH 2 ) 0-4 —O—R 150 ′—COOH, —(CH 2 ) 0-4 —S—(R 150 ), —(CH 2 ) 0-4 —N(R 150 )—SO 2 —R 105 , —(CH 2 ) 0-4 —C 3 -C 7 cycloalkyl, (C 2 -C 10 )alkenyl, and (C 2 -C 10 )alkynyl, or
R 100 is C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 R 115 groups, or
R 100 is —(C 1 -C 6 alkyl)-O—C 1 -C 6 alkyl) or —(C 1 -C 6 alkyl)-S—(C 1 -C 6 alkyl), each of which is optionally substituted with 1, 2, or 3 R 115 groups, or
R 100 is C 3 -C 8 cycloalkyl optionally substituted with 1, 2, or 3 R 115 groups;
W is —(CH 2 ) 0-4 —, —O—, —S(O) 0-2 —, —N(R 135 )—, —CR(OH)— or —C(O)—;
R 102 and R 102 ′ independently are hydrogen, or
C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, aryl or —R 110 ;
R 105 and R′ 105 independently represent —H, —R 110 , —R 120 , C 3 -C 7 cycloalkyl, —(C 1 -C 2 alkyl)-(C 3 -C 7 cycloalkyl), —(C 1 -C 6 alkyl)-O—(C 1 -C 3 alkyl), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 1 -C 6 alkyl chain with one double bond and one triple bond, or
C 1 -C 6 alkyl optionally substituted with —OH or —NH 2 ; or,
C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, or
R 105 and R′ 105 together with the atom to which they are attached form a 3 to 7 membered carbocylic ring, where one member is optionally a heteroatom selected from —O—, —S(O) 0-2 —, —N(R 135 )—, the ring being optionally substituted with 1, 2 or 3 independently selected R 140 groups;
R 115 at each occurrence is independently halogen, —OH, —CO 2 R 102 , —C 1 -C 6 thioalkoxy, —CO 2 -phenyl, —NR 105 R′ 135 , —SO 2 —(C 1 -C 8 alkyl), —C(═O)R 180 , R 180 , —CONR 105 R′ 105 , —SO 2 NR 105 R′ 105 , —NH—CO—(C 1 -C 6 alkyl), —NH—C(═O)—OH, —NH—C(═O)—OR, —NH—C(═O)—O-phenyl, —O—C(═O)—(C 1 -C 6 alkyl), —O—C(═O)-amino, —O—C(═O)-mono- or dialkylamino, —O—C(═O)-phenyl, —O—(C 1 -C 6 alkyl)-CO 2 H, —NH—SO 2 — (C 1 -C 6 alkyl), C 1 -C 6 alkoxy or C 1 -C 6 haloalkoxy;
R 135 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, —(CH 2 ) 0-2 -(aryl), —(CH 2 ) 0-2 -(heteroaryl), or —(CH 2 ) 0-2 -(heterocyclyl);
R 140 is heterocyclyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, cyano, nitro, amino, mono(C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, amino(C 1 -C 6 )alkyl, mono(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, and ═O;
R 145 is C 1 -C 6 alkyl or CF 3 ;
R 150 is hydrogen, C 3 -C 7 cycloalkyl, —(C 1 -C 2 alkyl)-(C 3 -C 7 cycloalkyl), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkyl with one double bond and one triple bond, —R 110 , —R 120 , or
C 1 -C 6 alkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from —OH, —NH 2 , C 1 -C 3 alkoxy, R 110 , and halogen;
R 150 ′ is C 3 -C 7 cycloalkyl, —(C 1 -C 3 alkyl)-(C 3 -C 7 cycloalkyl), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkyl with one double bond and one triple bond, —R 110 , —R 120 , or
C 1 -C 6 alkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from —OH, —NH 2 , C 1 -C 3 alkoxy, R 110 , and halogen;
R 155 is C 3 -C 7 cycloalkyl, —(C 1 -C 2 alkyl)-(C 3 -C 7 cycloalkyl), C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkyl with one double bond and one triple bond, —R 110 , —R 120 , or
C 1 -C 6 alkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from —OH, —NH 2 , C 1 -C 3 alkoxy, and halogen;
R 180 is selected from morpholinyl, thiomorpholinyl, piperazinyl, piperidinyl, homomorpholinyl, homothiomorpholinyl, homothiomorpholinyl S-oxide, homothiomorpholinyl S,S-dioxide, pyrrolinyl and pyrrolidinyl, each of which is optionally substituted with 1, 2, 3, or 4 groups independently selected from C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, cyano, nitro, amino, mono(C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, amino(C 1 -C 6 )alkyl, mono(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, di(C 1 -C 6 )alkylamino(C 1 -C 6 )alkyl, and ═O;
R 110 is aryl optionally substituted with 1 or 2 R 125 groups;
R 125 at each occurrence is independently halogen, amino, mono- or dialkylamino, —OH, —C≡N, —SO 2 —NH 2 , —SO 2 —NH—C 1 -C 6 alkyl, —SO 2 —N(C 1 -C 6 alkyl) 2 , —SO 2 —(C 1 -C 4 alkyl), —CO—NH 2 , —CO—NH—C 1 -C 6 alkyl, or —CO—N(C 1 -C 6 alkyl) 2 , or
C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, each of which is optionally substituted with 1, 2, or 3 groups that are independently selected from C 1 -C 3 alkyl, halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, amino, and mono- and dialkylamino, or
C 1 -C 6 alkoxy optionally substituted with one, two or three of halogen;
R 120 is heteroaryl, which is optionally substituted with 1 or 2 R 125 groups; and
R 130 is heterocyclyl optionally substituted with 1 or 2 R 125 groups.
2 . A compound according to claim 1 wherein R N is hydrogen.
3 . A compound according to claim 1 wherein R N ′ is hydrogen.
4 . A compound according to claim 1 wherein
R 1 is —C 1 -C 6 alkyl-aryl, —C 1 -C 6 alkyl-heteroaryl, or —C 1 -C 6 alkyl-heterocyclyl, where the ring portions of each are optionally substituted with 1, 2, 3, or 4 groups independently selected from halogen, —OH, —SH, —C≡N, —NO 2 , —NR 105 R′ 105 , —CO 2 R, —N(R)COR′, or —N(R)SO 2 R′, —C(═O)—(C 1 -C 4 )alkyl, —SO 2 -amino, —SO 2 -mono or dialkylamino, —C(═O)-amino, —C(═O)-mono or dialkylamino, —SO 2 —(C 1 -C 4 )alkyl, or
C 1 -C 6 alkoxy optionally substituted with 1, 2, or 3 groups which are independently selected from halogen, or
C 3 -C 7 cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, amino, —C 1 -C 6 alkyl and mono- or dialkylamino, or
C 1 -C 10 alkyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N, —CF 3 , —C 1 -C 3 alkoxy, amino, mono- or dialkylamino and —C 1 -C 3 alkyl, or
C 2 -C 10 alkenyl or C 2 -C 10 alkynyl each of which is optionally substituted with 1, 2, or 3 groups independently selected from halogen, —OH, —SH, —C≡N—CF 3 , C 1 -C 3 alkoxy, amino, C 1 -C 6 alkyl and mono- or dialkylamino; and the heterocyclyl group is optionally further substituted with oxo.
5 . A compound according to claim 1 wherein
R 2 and R 3 are independently selected from H or C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C 1 -C 3 alkyl, halogen, —OH, —SH, —C≡N, —CF 3 , C 1 -C 3 alkoxy, and —NR 1-a R 1-b .
6 . A compound according to claim 1 wherein
R C is —(CR 245 R 250 ) 0-4 -aryl, or —(CR 245 R 250 ) 0-4 -heteroaryl, wherein aryl and heteroaryl are optionally substituted with 1, 2, or 3 R 200 groups.
7 . A compound according to claim 2 wherein
R N ′ is
wherein
R 4 is NH 2 ; —NH— (CH 2 ) n6 —R 4-1 ; —NHR 8 ; —NR 50 C(O)R 5 ; or —NR 50 CO 2 R 51 ;
wherein
n 6 is 0, 1, 2, or 3;
n 7 is 0, 1, 2, or 3;
R 4-1 is selected from the group consisting of —SO 2 —(C 1 -C 8 alkyl), —SO—(C 1 -C 8 alkyl), —S—(C 1 -C 8 alkyl), —S—CO—(C 1 -C 6 alkyl), —SO 2 —NR 4-2 R 4-3 ; —CO—C 1 -C 2 alkyl; —CO—NR 4-3 R 4-4 ;
R 4-2 and R 4-3 are independently H, C 1 -C 3 alkyl, or C 3 -C 6 cycloalkyl;
R 4-4 is alkyl, phenylalkyl, C 2 -C 4 alkanoyl, or phenylalkanoyl;
R 5 is cyclopropyl; cyclobutyl; cyclopentyl; and cyclohexyl; wherein each cycloalkyl group is optionally substituted with one or two groups that are C 1 -C 6 alkyl, more preferably C 1 -C 2 alkyl, C 1 -C 6 alkoxy, more preferably C 1 -C 2 alkoxy, CF 3 , OH, NH 2 , NH(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), halogen, CN, or NO 2 ; or the cycloalkyl group is substituted with 1 or 2 groups that are independently CF 3 , Cl, F, methyl, ethyl or cyano; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, —NR 6 R 7 , C 1 -C 4 alkoxy, C 5 -C 6 heterocycloalkyl, C 5 -C 6 heteroaryl, phenyl, C 3 -C 7 cycloalkyl, —S—C 1 -C 4 alkyl, —SO 2 —C 1 -C 4 alkyl, —CO 2 H, —CONR 6 R 7 , —CO 2 —C 1 -C 4 alkyl, or phenyloxy; heteroaryl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 1 -C 4 haloalkyl, or OH; heterocycloalkyl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, or C 2 -C 4 alkanoyl; phenyl optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 haloalkyl; and —NR 6 R 7 ; wherein
R 6 and R 7 are independently selected from the group consisting of H, C 1 -C 6 alkyl, C 2 -C 6 alkanoyl, phenyl, —SO 2 —C 1 -C 4 alkyl, and phenyl C 1 -C 4 alkyl;
R 8 is selected from the group consisting of —SO 2 -heteroaryl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl or halogen; —SO 2 -aryl, —SO 2 -heterocycloalkyl, —C(O)NHR 9 , heterocycloalkyl, —S—C 2 -C 4 alkanoyl, wherein
R 9 is phenyl C 1 -C 4 alkyl, C 1 -C 6 alkyl, or H; R 50 is H or C 1 -C 6 alkyl;
R 51 is selected from the group consisting of phenyl C 1 -C 4 alkyl; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, cyano, —NR 6 R 7 , —C(O)NR 6 R 7 , C 3 -C 7 or —C 1 -C 4 alkoxy; heterocycloalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 2 -C 4 alkanoyl, phenyl C 1 -C 4 alkyl, and —SO 2 C 1 -C 4 alkyl; heterocycloalkylalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 2 -C 4 alkanoyl, phenyl C 1 -C 4 alkyl, and —SO 2 C 1 -C 4 alkyl; alkenyl; alkynyl; heteroaryl optionally substituted with 1, 2, or 3 groups that are independently OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl); heteroarylalkyl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl); phenyl; C 3 -C 8 cycloalkyl, and cycloalkylalkyl, wherein the phenyl; C 3 -C 8 cycloalkyl, and cycloalkylalkyl groups are optionally substituted with 1, 2, 3, 4 or 5 groups that are independently halogen, CN, NO 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkanoyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxy, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 1 -C 6 thioalkoxy, C 1 -C 6 thioalkoxy C 1 -C 6 alkyl, or C 1 -C 6 alkoxy C 1 -C 6 alkoxy.
8 . A compound according to claim 3 wherein
R N is
wherein
R 4 is NH 2 ; —NH—(CH 2 ) n6 —R 4-1 ; —NHR 8 ; —NR 50 C(O)R 5 ; or —NR 50 CO 2 R 51 ;
wherein
n 6 is 0, 1, 2, or 3;
n 7 is 0, 1, 2, or 3;
R 4-1 is selected from the group consisting of —SO 2 —(C 1 -C 8 alkyl), —SO—(C 1 -C 8 alkyl), —S—(C 1 -C 8 alkyl), —S—CO—(C 1 -C 6 alkyl), —SO 2 —NR 4-2 R 4-3 ; —CO—C 1 -C 2 alkyl; —CO—NR 4-3 R 4-4 ;
R 4-2 and R 4-3 are independently H, C 1 -C 3 alkyl, or C 3 -C 6 cycloalkyl;
R 4-4 is alkyl, phenylalkyl, C 2 -C 4 alkanoyl, or phenylalkanoyl;
R 5 is cyclopropyl; cyclobutyl; cyclopentyl; and cyclohexyl; wherein each cycloalkyl group is optionally substituted with one or two groups that are C 1 -C 6 alkyl, more preferably C 1 -C 2 alkyl, C 1 -C 6 alkoxy, more preferably C 1 -C 2 alkoxy, CF 3 , OH, NH 2 , NH(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), halogen, CN, or NO 2 ; or the cycloalkyl group is substituted with 1 or 2 groups that are independently CF 3 , Cl, F, methyl, ethyl or cyano; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, —NR 6 R 7 , C 1 -C 4 alkoxy, C 5 -C 6 heterocycloalkyl, C 5 -C 6 heteroaryl, phenyl, C 3 -C 7 cycloalkyl, —S—C 1 -C 4 alkyl, —SO 2 —C 1 -C 4 alkyl, —CO 2 H, —CONR 6 R 7 , —CO 2 —C 1 -C 4 alkyl, or phenyloxy; heteroaryl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 1 -C 4 haloalkyl, or OH; heterocycloalkyl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, or C 2 -C 4 alkanoyl; phenyl optionally substituted with 1, 2, 3, or 4 groups that are independently halogen, OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 haloalkyl; and —NR 6 R 7 ; wherein
R 6 and R 7 are independently selected from the group consisting of H, C 1 -C 6 alkyl, C 2 -C 6 alkanoyl, phenyl, —SO 2 —C 1 -C 4 alkyl, and phenyl C 1 -C 4 alkyl;
R 8 is selected from the group consisting of —SO 2 -heteroaryl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl or halogen; —SO 2 -aryl, —SO 2 -heterocycloalkyl, —C(O)NHR 9 , heterocycloalkyl, —S—C 2 -C 4 alkanoyl, wherein
R 9 is phenyl C 1 -C 4 alkyl, C 1 -C 6 alkyl, or H; R 50 is H or C 1 -C 6 alkyl;
R 51 is selected from the group consisting of phenyl C 1 -C 4 alkyl; C 1 -C 6 alkyl optionally substituted with 1, 2, or 3 groups that are independently halogen, cyano, —NR 6 R 7 , —C(O)NR 6 R 7 , C 3 -C 7 or —C 1 -C 4 alkoxy; heterocycloalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 2 -C 4 alkanoyl, phenyl C 1 -C 4 alkyl, and —SO 2 C 1 -C 4 alkyl; heterocycloalkylalkyl optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, C 2 -C 4 alkanoyl, phenyl C 1 -C 4 alkyl, and —SO 2 C 1 -C 4 alkyl; alkenyl; alkynyl; heteroaryl optionally substituted with 1, 2, or 3 groups that are independently OH, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl); heteroarylalkyl optionally substituted with 1, 2, or 3 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl); phenyl; C 3 -C 8 cycloalkyl, and cycloalkylalkyl, wherein the phenyl; C 3 -C 8 cycloalkyl, and cycloalkylalkyl groups are optionally substituted with 1, 2, 3, 4 or 5 groups that are independently halogen, CN, NO 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkanoyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, hydroxy, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 1 -C 6 thioalkoxy, C 1 -C 6 thioalkoxy C 1 -C 6 alkyl, or C 1 -C 6 alkoxy C 1 -C 6 alkoxy.
9 . A compound according to claim 2 wherein
R N ′ is —C(═O)-phenyl, where the phenyl ring is optionally substituted with 1 or 2 groups independently selected from
C 1 -C 6 alkyl, halogen, —(CH 2 ) 0-4 —CO—NR 105 R′ 105 , —(CH 2 ) 0-4 —O—CO—N(R 150 ) 2 , —(CH 2 ) 0-4 —N(R 150 )—SO 2 —R 105 , —(CH 2 ) 0-4 —SO 2 —NR 105 R′ 105 , C 3 -C 7 cycloalkyl, (C 2 -C 10 )alkenyl, —(CH 2 ) 0-4 —R 110 , —(CH 2 ) 0-4 —R 120 , —(CH 2 ) 0-4 —R 130 , or (C 2 -C 10 )alkynyl.
10 . A compound according to claim 3 wherein
R N is —C(═O)-phenyl, where the phenyl ring is optionally substituted with 1 or 2 groups independently selected from
C 1 -C 6 alkyl, halogen, —(CH 2 ) 0-4 —CO—NR 105 R′ 105 , —(CH 2 ) 0-4 —O—CO—N(R 150 ) 2 , —(CH 2 ) 0-4 —N(R 150 )—SO 2 —R 105 , —(CH 2 ) 0-4 —SO 2 —NR 105 R′ 105 , C 3 -C 7 cycloalkyl, (C 2 -C 10 )alkenyl, —(CH 2 ) 0-4 —R 110 , —(CH 2 ) 0-4 —R 120 , —(CH 2 ) 0-4 —R 130 , or (C 2 -C 10 )alkynyl.
11 . A compound according to claim 1 selected from the group consisting of:
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-D-
alaninamide dihydrochloride
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 [(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]-D-alaninamide trifluoroacetate
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(methylsulfonyl)amino]-
1,3-thiazole-5-carboxamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-L-alaninamide bis(trifluoroacetate)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N-(3-
ethylbenzyl)propanamide hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)propanoate
dihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
dihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
dihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
dihydrochloride
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N\(u)1\(d)-(3-ethylbenzyl)-5-(1,3-oxazol-2-
yl)-N 3 ,N 3 -dipropylisophthalamide hydrochloride
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-(1,3-oxazol-2-yl)-N 3 ,N 3 -dipropyl-N 1 -[3-
(trifluoromethyl)benzyl]isophthalamide hydrochloride
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-(1,3-oxazol-2-yl)-N 3 ,N 3 -dipropyl-N 1 -[3-
(trifluoromethyl)benzyl]isophthalamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-
N 2 [(methoxy)carbonyl]-D-alaninamide dihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-{[(2-hydroxyethyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(2-
isobutyl-1,3-thiazol-5-yl)methyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
isopropylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
isopropylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-(4-methyl-1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(2-
isobutyl-1,3-thiazol-5-yl)methyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-{[(3-hydroxypropyl)amino]sulfonyl}benzoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
propylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[butyl(methyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethynylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(3-
isobutylisoxazol-5-yl)methyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dimethylamino)sulfonyl]-
5-[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-(1,3-oxazol-2-yl)benzoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(5-
formyl-2-thienyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 3-bromo-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
isobutylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(2R)-2-
(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzoate
hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[butyl(propyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dibutylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(3-
hydroxyprop-1-yn-1-yl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[butyl(ethyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethynylbenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[cyclohexyl(methyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-1-({[3-
(cyclopropylamino)benzyl]amino}methyl)-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(3-
thienyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-(piperazin-1-ylsulfonyl)benzoate dihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
iodophenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-sec-butylbenzyl)amino]methyl}-3-
(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-(3-methylisoxazol-4-yl)benzoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
isobutylisoxazol-5-yl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-[(dipropylamino)carbonyl]-
6-methylisonicotinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[(cyclopropylmethyl)(propyl)amino]carbonyl}-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(aminosulfonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-[(1Z)-
prop-1-en-1-yl]benzyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-(1H-pyrazol-4-yl)benzoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)-1-methylethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-1-{[(3-allylbenzyl)amino]methyl}-2-amino-3-
(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)-1-methylethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[ethyl(propyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-1-({[3-
(cyclopropylamino)benzyl]amino}methyl)-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
isobutylisoxazol-5-yl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(5-
formyl-4-methyl-2-thienyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
isopropylbenzyl)amino]methyl}propyl 5-
[(dipropylamino)carbonyl]nicotinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-
[(methylsulfonyl)amino]benzyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(butylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(3-
methylbutyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(biphenyl-3-ylmethyl)amino]methyl}-
3-(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-({[2-(methylamino)ethyl]amino}sulfonyl)benzoate
hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
isobutylisoxazol-5-yl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-ethynylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(diallylamino)carbonyl]-
5-methylbenzoate
(1R,2R)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(2-
isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)-1-methylethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(2-
hydroxyethyl)amino]sulfonyl}-5-
[(propylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methyl-5-
{[methyl(propyl)amino]carbonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(phenylsulfonyl)-3-[(1-
propylbutyl)sulfonyl]alaninate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(diethylamino)carbonyl]-
5-(1,3-oxazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzylamino)carbonyl]-3-
[(1-propylbutyl)sulfonyl]alaninate trifluoroacetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-pyridin-
3-ylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-
[(dipropylamino)carbonyl]nicotinate 1-oxide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(3-
formyl-2-furyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-(1-methyl-1H-imidazol-2-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(diethylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(ethylsulfinyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[butyl(ethyl)amino]sulfonyl}propanoate
(1R,2S)-2-amino-1-{[(3-cyanobenzyl)amino]methyl}-3-
(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-
propylbutyl)sulfonyl]propanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[isobutyl(methyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-pyridin-
2-ylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 2-[(methylsulfonyl)amino]-
1,3-oxazole-4-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-
[methyl(methylsulfonyl)amino]benzyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-phenylpropanoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate trifluoroacetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(ethylsulfonyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(5-chloro-2-
thienyl)sulfonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
hydrochloride
(1R,2S)-1-({[3-(5-acetyl-2-
thienyl)benzyl]amino}methyl)-2-amino-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(sec-
butylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(1,3-oxazol-2-yl)benzoate
hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methyl-5-{[methyl(2-
phenylethyl)amino]carbonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(3,5-
dimethylisoxazol-4-yl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methyl-5-{[methyl(prop-2-
yn-1-yl)amino]carbonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[ethyl(methyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
{[(dimethylamino)carbonyl]oxy}benzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[benzyl(methyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[sec-
butyl(propyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(4-
methyl-2-thienyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-
[(methoxycarbonyl)(methyl)amino]benzyl}amino)methyl]propyl
3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)-3-(2,3,5-
trifluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
[(diisobutylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methyl-5-{[methyl(2-
pyridin-2-ylethyl)amino]carbonyl}benzoate
(1R,2S)-2-amino-3-(3-fluoro-5-hydroxyphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate hydrochloride
(1R,2S)-2-amino-3-(3-chloro-5-fluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 4-hydroxy-3-(pyrrolidin-1-
ylcarbonyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-D-prolyl-3-[(1-
propylbutyl)sulfonyl]alaninate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-pyridin-
4-ylbenzyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-
[(dimethylamino)sulfonyl]benzyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(6-methoxy-
1,2,3,4-tetrahydronaphthalen-1-yl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(phenylacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(azepan-1-ylcarbonyl)-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-
[(methoxycarbonyl)amino]benzyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-L-prolyl-3-[(1-
propylbutyl)sulfonyl]alaninate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(isobutylamino)carbonyl]-
5-methylbenzoate
4-[((1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl)oxy]-4-oxo-3-{[(1-
propylbutyl)sulfonyl]methyl}butanoic acid trifluoroacetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
[methyl(methylsulfonyl)amino]benzoate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-{[(2-
hydroxyethyl)amino]sulfonyl}-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N-[(2-isobutyl-1,3-thiazol-5-
yl)methyl]-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N-(3-isopropylbenzyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-isopropylbenzyl)-5-(1,3-oxazol-2-yl)-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-{[(2-hydroxy-1,1-
dimethylethyl)amino]sulfonyl}-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(4-methyl-1,3-oxazol-2-
yl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(2-isobutyl-1,3-thiazol-5-yl)methyl]-5-
(1,3-oxazol-2-yl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-{[(3-
hydroxypropyl)amino]sulfonyl}-N′,N′-dipropylisophthalamide
hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N′,N′-dipropyl-N-(3-
propylbenzyl)isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-butyl-N-(3-ethylbenzyl)-N′,5-
dimethylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N-(3-ethynylbenzyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N-[(3-isobutylisoxazol-5-yl)methyl]-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-[(dimethylamino)sulfonyl]-N-(3-ethylbenzyl)-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(1,3-oxazol-2-yl)-N′,N′-
dipropylisophthalamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(5-formyl-2-thienyl)benzyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-bromo-N-(3-iodobenzyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-({[(1R)-2-hydroxy-1-
methylethyl]amino}sulfonyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-isobutylbenzyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N′,N′-dipropyl-N-[3-
(trifluoromethyl)benzyl]isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[(2R)-2-
(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide
hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-({[(1S)-2-hydroxy-1-
methylethyl]amino}sulfonyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-butyl-N-(3-ethylbenzyl)-5-methyl-N′-
propylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′,N′-dibutyl-N-(3-ethylbenzyl)-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(3-hydroxyprop-1-yn-1-yl)benzyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-{[(2S)-2-
(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-butyl-N′-ethyl-N-(3-ethylbenzyl)-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethynylbenzyl)-5-(1,3-oxazol-2-yl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-cyclohexyl-N-(3-ethylbenzyl)-N′,5-
dimethylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(cyclopropylamino)benzyl]-5-ethynyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N′,N′-dipropyl-N-[3-(3-
thienyl)benzyl]isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-(1,3-oxazol-2-yl)-N′,N′-dipropyl-N-[3-
(trifluoromethyl)benzyl]isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(piperazin-1-ylsulfonyl)-
N′,N′-dipropylisophthalamide dihydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-iodophenyl)cyclopropyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-sec-butylbenzyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(3-methylisoxazol-4-yl)-
N′,N′-dipropylisophthalamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-isobutylisoxazol-5-yl)cyclopropyl]-5-
(1,3-oxazol-2-yl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethylphenyl)cyclopropyl]-5-(1,3-
oxazol-2-yl)-N′,N′-dipropylisophthalamide
N 4 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 4 -(3-ethylbenzyl)-6-methyl-N 2 ,N 2 -
dipropylpyridine-2,4-dicarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(cyclopropylmethyl)-N-(3-ethylbenzyl)-5-
methyl-N′-propylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-5-(1,3-oxazol-2-yl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethynylphenyl)cyclopropyl]-5-(1,3-
oxazol-2-yl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-(aminosulfonyl)-N-(3-ethylbenzyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-{3-[(1Z)-prop-1-en-1-yl]benzyl}-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,N′-dipropyl-5-(1H-
pyrazol-4-yl)isophthalamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethylphenyl)-1-methylethyl]-5-ethynyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N′,N′-dipropyl-N-[3-
(trifluoromethyl)benzyl]isophthalamide
N-(3-allylbenzyl)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethylphenyl)cyclopropyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethylphenyl)-1-methylethyl]-5-(1,3-
oxazol-2-yl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-ethyl-N-(3-ethylbenzyl)-5-methyl-N′-
propylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(cyclopropylamino)benzyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N-[1-(3-ethynylphenyl)cyclopropyl]-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-isobutylisoxazol-5-yl)cyclopropyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(5-formyl-4-methyl-2-thienyl)benzyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-isopropylbenzyl)-N′,N′-dipropylpyridine-
3,5-dicarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-{3-[(methylsulfonyl)amino]benzyl}-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-butyl-N-(3-ethylbenzyl)-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[3-(3-methylbutyl)benzyl]-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(biphenyl-3-ylmethyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethynylphenyl)cyclopropyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-({[2-
(methylamino)ethyl]amino}sulfonyl)-N′,N′-
dipropylisophthalamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-ethynyl-N-[1-(3-isobutylisoxazol-5-
yl)cyclopropyl]-N′,N′-dipropylisophthalamide
N,N-diallyl-N′-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-
2-hydroxybutyl]-N′-(3-ethylbenzyl)-5-methylisophthalamide
N-[(2R,3R)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(2-isobutyl-1,3-thiazol-5-
yl)cyclopropyl]-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(3-ethylphenyl)-1-methylethyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-{[(2-
hydroxyethyl)amino]sulfonyl}-N′-propylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,5-dimethyl-N′-
propylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(phenylsulfonyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′,N′-diethyl-N-(3-ethylbenzyl)-5-(1,3-oxazol-
2-yl)isophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -[(benzylamino)carbonyl]-N 1 -(3-ethylbenzyl)-
3-[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate
(salt)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N′,N′-dipropyl-N-(3-pyridin-3-
ylbenzyl)isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,N′-dipropylpyridine-3,5-
dicarboxamide 1-oxide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-ethyl-N-[3-(3-formyl-2-furyl)benzyl]-5-
methyl-N′-propylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(1-methyl-1H-imidazol-2-
yl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′,N′-diethyl-N-(3-ethylbenzyl)-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(ethylsulfinyl)benzyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-{[butyl(ethyl)amino]sulfonyl}-N-(3-
ethylbenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-cyanobenzyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]propanamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-isobutyl-N′,5-
dimethylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N′,N′-dipropyl-N-(3-pyridin-2-
ylbenzyl)isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-iodobenzyl)-2-[(methylsulfonyl)amino]-
1,3-oxazole-4-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-{3-
[methyl(methylsulfonyl)amino]benzyl}-N′,N′-
dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(3-phenylpropanoyl)-3-
[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate (salt)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(ethylsulfonyl)benzyl]-5-methyl-N′,N′-
dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -[(5-chloro-2-thienyl)sulfonyl]-N 1 -(3-
ethylbenzyl)-3-[(1-propylbutyl)sulfonyl]alaninamide
hydrochloride
N-[3-(5-acetyl-2-thienyl)benzyl]-N-[(2R,3S)-3-amino-4-
(3,5-difluorophenyl)-2-hydroxybutyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(sec-butyl)-N-(3-ethylbenzyl)-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(1,3-oxazol-2-yl)benzamide
hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,5-dimethyl-N′-(2-
phenylethyl)isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(3,5-dimethylisoxazol-4-yl)benzyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,5-dimethyl-N′-prop-2-yn-
1-ylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-ethyl-N-(3-ethylbenzyl)-N′,5-
dimethylisophthalamide
3-[([(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}amino)methyl]phenyl dimethylcarbamate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-benzyl-N-(3-ethylbenzyl)-N′,5-
dimethylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(sec-butyl)-N-(3-ethylbenzyl)-5-methyl-N′-
propylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[3-(4-methyl-2-thienyl)benzyl]-
N′,N′-dipropylisophthalamide
methyl {3-[([(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}amino)methyl]phenyl}methylcarbamate
N-[(2R,3S)-3-amino-2-hydroxy-4-(2,3,5-
trifluorophenyl)butyl]-5-methyl-N′,N′-dipropyl-N-[3-
(trifluoromethyl)benzyl]isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,N′-diisobutyl-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,5-dimethyl-N′-(2-pyridin-
2-ylethyl)isophthalamide
N-[(2R,3S)-3-amino-4-(3-fluoro-5-hydroxyphenyl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-5-methyl-N′,N′-
dipropylisophthalamide hydrochloride
N 1 -[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-hydroxy-N-(3-iodobenzyl)-3-(pyrrolidin-1-
ylcarbonyl)benzamide
5-oxo-D-prolyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N′,N′-dipropyl-N-(3-pyridin-4-
ylbenzyl)isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-{3-[(dimethylamino)sulfonyl]benzyl}-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-
yl)-5-methyl-N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(phenylacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(azepan-1-ylcarbonyl)-N-(3-ethylbenzyl)-5-
methylbenzamide
methyl {3-[([(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}amino)methyl]phenyl}carbamate
5-oxo-L-prolyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-isobutyl-5-
methylisophthalamide
4-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-4-oxo-3-{[(1-
propylbutyl)sulfonyl]methyl}butanoic acid trifluoroacetate
(salt)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-
[methyl(methylsulfonyl)amino]benzamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[ethyl(isopropyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(2-thienyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(2-
hydroxyethyl)(propyl)amino]sulfonyl}propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[isopropyl(methyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-[(methylsulfonyl)amino]-
1,3-thiazole-4-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[allyl(cyclopentyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(3-
methylbutyl)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(5-
methyl-2-thienyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(3-methoxyphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(1-
methylhexyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-1-({[1-
(aminocarbonyl)cyclohexyl]amino}methyl)-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2E)-hex-2-
en-1-ylamino]methyl}propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(4-fluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-hydroxyisoxazole-5-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-[(1E)-
hex-1-en-1-yl]benzyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
[(isopropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(2-thienyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl [3-(2-amino-2-
oxoethoxy)phenyl]acetate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2-
ethylhexyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(6-
methoxypyridin-3-yl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-(2,4-
dimethoxypyrimidin-5-yl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-ethylbutanoyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(4-hydroxypiperidin-1-
yl)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 4-[2′-
(aminocarbonyl)biphenyl-4-yl]-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(3-hydroxypiperidin-1-
yl)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-hydroxy-
1-phenylpropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[[2-
(dimethylamino)ethyl](ethyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-methyl-4H,6H-pyrrolo[1,2-
a][4,1]benzoxazepine-4-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (5-acetyl-2-thienyl)acetate
(1R,2S)-2-amino-3-(3,5-dichlorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
[(diisopropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
[(methylsulfonyl)amino]benzoate
(1R,2S)-2-amino-3-(4-chlorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl [4-(2-oxopyrrolidin-1-
yl)phenyl]acetate
(1R,2S)-2-amino-3-(3-chloro-5-fluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3-chloro-5-fluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(1-methyl-1H-imidazol-4-
yl)sulfonyl]amino}benzoate trihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-
[(pentylamino)methyl]propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(4-fluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-chloro-5-
fluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[cyclohexyl(ethyl)amino]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[2-({[(2,4-
difluorophenyl)amino]carbonyl}oxy)ethyl]amino}methyl)propyl
3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(2S)-2-
(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzoate
hydrochloride
(1R,2S)-2-amino-3-(3-fluoro-4-methylphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2,8-dimethylquinoline-3-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(6-
hydroxyhexyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(2R)-2-
hydroxypropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-[(1-propylbutyl)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(2-hydroxy-1,1-
dimethylethyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(4-
phenylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 7-(1H-imidazol-1-yl)-5,6-
dihydronaphthalene-2-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(acetylamino)-4-
methylbenzoate
(1R,2S)-2-amino-1-({[2-
(aminosulfonyl)ethyl]amino}methyl)-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[2-
(ethylthio)ethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-cyclohexyl-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[benzyl(cyanomethyl)amino]methyl}-3-
(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2-
hydroxypropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-butoxypropyl)amino]methyl}-3-
(3,5-difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[2-(2-
hydroxyethyl)piperidin-1-yl]carbonyl}-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(1-hydroxy-2-
propylpentyl)benzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-chloro-5-
fluorophenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-
[(methylsulfonyl)amino]butanoate trifluoroacetate
(1R,2S)-2-amino-1-({[3-(1-benzothien-2-
yl)benzyl]amino}methyl)-3-(3,5-difluorophenyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(benzyloxy)isoxazole-5-
carboxylate
(1R,2S)-2-amino-1-{[(cyclopropylmethyl)amino]methyl}-3-
(3,5-difluorophenyl)propyl N-[(benzyloxy)carbonyl]-3-[(1-
propylbutyl)sulfonyl]alaninate trifluoroacetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-(1H-pyrazol-1-
yl)pentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1-(2-furylmethyl)-5-
oxopyrrolidine-3-carboxylate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-ethylhexanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(5-
hydroxypentyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]piperidine-1-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(diethylamino)carbonyl]piperidine-1-carboxylate
(1R,2S)-2-amino-3-(pentafluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-bromo-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-
[(methylsulfonyl)amino]benzoate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(2-thienyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethoxypropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(2-
thienyl)propyl 3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-
(phenylsulfonyl)butanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-dichlorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
[3-(trifluoromethoxy)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-ethyl-N-(3-ethylbenzyl)-N′-isopropyl-5-
methylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-N-(3-
methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[(2-
hydroxyethyl)(propyl)amino]sulfonyl}propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-isopropyl-N′,5-
dimethylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(methylsulfonyl)amino]-
1,3-thiazole-4-carboxamide
N-allyl-N′-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-cyclopentyl-N′-(3-ethylbenzyl)-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-[(3-
methylbutyl)sulfonyl]propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[3-(5-methyl-2-thienyl)benzyl]-
N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(3-
methoxyphenyl)butyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(1-methylhexyl)-N′,N′-
dipropylisophthalamide
N-[1-(aminocarbonyl)cyclohexyl]-N-[(2R,3S)-3-amino-4-
(3,5-difluorophenyl)-2-hydroxybutyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(2E)-hex-2-en-1-yl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(4-fluorophenyl)-2-hydroxybutyl]-
N-(3-methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-hydroxyisoxazole-5-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-{3-[(1E)-hex-1-en-1-yl]benzyl}-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-isopropyl-5-
methylisophthalamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-N 1 -(3-
methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
2(3-{2-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-iodobenzyl)amino]-2-
oxoethyl}phenoxy)acetamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-N-
(3-methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(2-ethylhexyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(6-methoxypyridin-3-yl)benzyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(2,4-dimethoxypyrimidin-5-yl)benzyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(2-ethylbutanoyl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-[(4-hydroxypiperidin-1-
yl)carbonyl]-5-methylbenzamide
N 1 -[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-
N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 4-[2′-
(aminocarbonyl)biphenyl-4-yl]-4-oxobutanoate
1-(3-{[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]carbonyl}-5-
methylbenzoyl)-L-prolinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-[(3-hydroxypiperidin-1-
yl)carbonyl]-5-methylbenzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-hydroxy-1-phenylpropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-[2-(dimethylamino)ethyl]-N′-ethyl-N-(3-
ethylbenzyl)-5-methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-methyl-4H,6H-pyrrolo[1,2-
a][4,1]benzoxazepine-4-carboxamide
2-(5-acetyl-2-thienyl)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-ethylbenzyl)acetamide
N 1 -[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′,N′-diisopropyl-5-
methylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-
[(methylsulfonyl)amino]benzamide
N 1 -[(2R,3S)-3-amino-4-(4-chlorophenyl)-2-hydroxybutyl]-
N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-iodobenzyl)-2-[4-(2-oxopyrrolidin-1-
yl)phenyl]acetamide
N-[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide
N 1 -[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[(1-methyl-1H-imidazol-4-
yl)sulfonyl]amino}benzamide trihydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-pentyl-N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(4-fluorophenyl)-2-hydroxybutyl]-
N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-cyclohexyl-N′-ethyl-N-(3-ethylbenzyl)-5-
methylisophthalamide
2-([(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}amino)ethyl (2,4-difluorophenyl)carbamate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[(2S)-2-
(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide
hydrochloride
N 1 -[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N 1 -[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-
N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2,8-dimethylquinoline-3-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(6-hydroxyhexyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(2R)-2-hydroxypropyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-3-[(1-propylbutyl)sulfonyl]propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[(2-hydroxy-1,1-
dimethylethyl)amino]sulfonyl}benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(4-phenylbutyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-7-(1H-imidazol-1-yl)-N-(3-iodobenzyl)-5,6-
dihydronaphthalene-2-carboxamide
3-(acetylamino)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-ethylbenzyl)-4-
methylbenzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[2-(aminosulfonyl)ethyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[2-(ethylthio)ethyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyl]-N-(3-
methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(2-hydroxypropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-butoxypropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[2-(2-
hydroxyethyl)piperidin-1-yl]carbonyl}-5-methylbenzamide
methyl N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}-β-alaninate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(1-hydroxy-2-
propylpentyl)benzamide
N 1 -[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-
[(methylsulfonyl)amino]butanamide trifluoroacetate (salt)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(1-benzothien-2-yl)benzyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(benzyloxy)-N-(3-ethylbenzyl)isoxazole-5-
carboxamide
1-(3-{[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]carbonyl}-5-
methylbenzoyl)-D-prolinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(1H-pyrazol-1-
yl)pentanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1-(2-furylmethyl)-5-
oxopyrrolidine-3-carboxamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-ethyl-N-
(3-methoxybenzyl)hexanamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(5-hydroxypentyl)-5-methyl-N′,N′-
dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylpiperidine-
1,3-dicarboxamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 3 ,N 3 -diethyl-N 1 -(3-methoxybenzyl)piperidine-
1,3-dicarboxamide
N-[(2R,3S)-3-amino-2-hydroxy-4-
(pentafluorophenyl)butyl]-5-bromo-N′,N′-dipropyl-N-[3-
(trifluoromethyl)benzyl]isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-
[(methylsulfonyl)amino]benzamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-3-
[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-3-
[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethoxypropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-N-
benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-
(phenylsulfonyl)butanamide hydrochloride
N 1 -[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N 1 -{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethoxy)phenyl]butyl}-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3,3-
dimethylbutyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-
bromophenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3-chloro-5-fluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(1,3-
diphenylpropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1S)-1-
(hydroxymethyl)propyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(3S)-2-
oxoazepan-3-yl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-(cyclohexylamino)-5-
oxopentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(3-methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(2-
propylpentyl)sulfonyl]-β-alaninate trifluoroacetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(1,3-thiazol-2-yl)benzoate
dihydrochloride
(1R,2S)-2-amino-3-(2-furyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({3-
[methyl(phenyl)amino]propyl}amino)methyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(4-methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-1-(2-
thienylmethyl)pyrrolidine-3-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(butylthio)methyl]-5-
methyl-2-furoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{[(2-
hydroxyethyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[3-
(trifluoromethyl)benzoyl]glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylcyclohexyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2-oxo-1,3-oxazolidin-3-
yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(1H-pyrrol-1-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(6-methoxy-
1,2,3,4-tetrahydronaphthalen-1-yl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1,3,4,5-
tetrahydrothiopyrano[4,3-b]indole-8-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-oxo-4-{[2-
(trifluoromethyl)phenyl]amino}butanoate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4,5-dimethyl-2-(1H-pyrrol-1-
yl)thiophene-3-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2,3-
dihydroxypropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(2S)-2-
hydroxypropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R)-1-
methylpropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-chloro-4-
(methylsulfonyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2-
hydroxyethyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(3-methoxyphenyl)propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{methyl[(trifluoromethyl)sulfonyl]amino}benzoate
hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-hydroxy-6-(1-hydroxy-2,2-
dimethylpropyl)pyridine-2-carboxylate
(1R,2S)-2-amino-1-{[(1,3-
dicyclohexylpropyl)amino]methyl}-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2,2′-bithiophene-5-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(1H-imidazol-1-
yl)butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2,3-dihydroxy-4-[(4-
methoxyphenyl)amino]-4-oxobutanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
hydroxyphenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
[3-(trifluoromethyl)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(2-
thienyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-({[2-(aminocarbonyl)-1H-indol-6-
yl]amino}methyl)-3-(3,5-difluorophenyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-
bromophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[4-
(trifluoromethyl)benzoyl]glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(1-oxo-1,3-dihydro-2H-
isoindol-2-yl)butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3,4-
dichlorobenzoyl)glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-chloro-4-
(methylsulfonyl)thiophene-2-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(1-
ethylpropyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({[(5R)-3-
ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)methyl]propyl
3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-methyl-7-
(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[(methylthio)acetyl]-3-[(1-
propylbutyl)sulfonyl]alaninate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2,3-
dimethylcyclohexyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4,5-dimethoxy-1-
benzothiophene-2-carboxylate
(1R,2S)-2-amino-3-[3-fluoro-5-(trifluoromethyl)phenyl]-
1-{[(3-methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({[(5S)-3-
ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)methyl]propyl
3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,5-dioxo-1,2,4-
triazolidin-4-yl)benzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-3-[(3-
methoxyphenyl)sulfonyl]propanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(2-
methylcyclohexyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-{[(2-{4-[(3-
chlorobenzyl)oxy]phenyl}ethyl)amino]methyl}-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-oxo-4-(3-
thienyl)butanoate
(1R,2S)-2-amino-3-[3-(benzyloxy)-5-fluorophenyl]-1-
{[(3-methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-oxo-4-[3-
(trifluoromethyl)phenyl]butanoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-[3-
(trifluoromethoxy)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-
(hydroxymethyl)-3-(methylthio)propyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(1H-1,2,3-benzotriazol-1-
yl)hexanoate
(1R,2S)-2-amino-3-(3-fluoro-4-methylphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-
{[(trifluoromethyl)sulfonyl]amino}butanoate trifluoroacetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (5-methyl-1,3-dioxo-1,3-
dihydro-2H-isoindol-2-yl)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
hydroxypropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-
(hydroxymethyl)propyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3,5-
dichlorophenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-{[(2-
hydroxyethyl)(propyl)amino]sulfonyl}propanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-(benzylthio)nicotinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1H-pyrazole-5-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-chloro-3-methyl-2-oxo-2,3-
dihydro-1,3-benzoxazole-5-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1H-benzimidazole-2-
carboxylate
(1R,2S)-2-amino-3-cyclohexyl-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-hydroxy-4,7-dimethoxy-1-
benzofuran-5-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(4-
methylcyclohexyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl[1,2,4]triazolo[4,3-
a]pyridine-6-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-oxo-4-(2-
thienyl)butanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3,5-
dichlorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2-hydroxy-5-
methylphenyl)-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-phenoxybenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-
[(aminocarbonyl)amino]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1S)-1-
(hydroxymethyl)-3-(methylthio)propyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 7-hydroxy-4-oxochromane-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1S)-1-
(hydroxymethyl)-3-methylbutyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R)-1-
(hydroxymethyl)propyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(1-methyl-3-
phenylpropyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3,3-dimethylbutyl)-5-methyl-N′,N′-
dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-
N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(3-methylbutyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(1,3-diphenylpropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1S)-1-(hydroxymethyl)propyl]-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[(3S)-2-oxoazepan-3-yl]-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-cyclohexyl-N-(3-ethylbenzyl)pentanediamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(3-methylphenyl)butyl]-
N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 3 -[(2-
propylpentyl)sulfonyl]-β-alaninamide trifluoroacetate (salt)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(1,3-thiazol-2-
yl)benzamide dihydrochloride
N-[(2R,3S)-3-amino-4-(2-furyl)-2-hydroxybutyl]-N-(3-
methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-{3-[methyl(phenyl)amino]propyl}-
N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(4-methylphenyl)butyl]-
N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-oxo-1-(2-
thienylmethyl)pyrrolidine-3-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-[(butylthio)methyl]-N-(3-ethylbenzyl)-5-
methyl-2-furamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{[(2-
hydroxyethyl)amino]sulfonyl}benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(3-methylcyclohexyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(2-oxo-1,3-oxazolidin-3-
yl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(1H-pyrrol-1-yl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-
yl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1,3,4,5-
tetrahydrothiopyrano[4,3-b]indole-8-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-[2-
(trifluoromethyl)phenyl]succinamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-5-
methyl-N-(3-methylbutyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4,5-dimethyl-2-(1H-pyrrol-1-
yl)thiophene-3-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(2,3-dihydroxypropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(2S)-2-hydroxypropyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[(1R)-1-methylpropyl]-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-chloro-N-(3-ethylbenzyl)-4-
(methylsulfonyl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(2-hydroxyethyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(3-methoxyphenyl)butyl]-
3-[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-
{methyl[(trifluoromethyl)sulfonyl]amino}benzamide
hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-hydroxy-6-(1-hydroxy-2,2-
dimethylpropyl)pyridine-2-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(1,3-dicyclohexylpropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2,2′-bithiophene-5-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(1H-imidazol-1-
yl)butanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2,3-dihydroxy-N′-(4-
methoxyphenyl)succinamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-hydroxyphenyl)butyl]-
N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N 1 -{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethyl)phenyl]butyl}-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-N 1 -
benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[2-(aminocarbonyl)-1H-indol-6-yl]-N-[(2R,3S)-3-amino-
4-(3,5-difluorophenyl)-2-hydroxybutyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-N-
benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(1-oxo-1,3-dihydro-2H-
isoindol-2-yl)butanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-chloro-N-(3-ethylbenzyl)-4-
(methylsulfonyl)thiophene-2-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(1-ethylpropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-{[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-
yl]methyl}-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-methyl-7-
(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-N 2 -[(methylthio)acetyl]-3-[(1-
propylbutyl)sulfonyl]alaninamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(2,3-dimethylcyclohexyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4,5-dimethoxy-1-
benzothiophene-2-carboxamide
N 1 -{(2R,3S)-3-amino-4-[3-fluoro-5-
(trifluoromethyl)phenyl]-2-hydroxybutyl}-N 1 -(3-methylbutyl)-
N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-{[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-
yl]methyl}-5-methyl-N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,5-dioxo-1,2,4-triazolidin-4-yl)-N-(3-
ethylbenzyl)benzamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-3-[(3-methoxyphenyl)sulfonyl]propanamide
hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(2-methylcyclohexyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(2-{4-[(3-chlorobenzyl)oxy]phenyl}ethyl)-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-oxo-4-(3-
thienyl)butanamide
N 1 -{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-oxo-4-[3-
(trifluoromethyl)phenyl]butanamide
N 1 -{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethoxy)phenyl]butyl}-N 1 -(3-methylbutyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(hydroxymethyl)-3-(methylthio)propyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(1H-1,2,3-benzotriazol-1-yl)-N-(3-
ethylbenzyl)hexanamide
N 1 -[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-N-
(3-ethylbenzyl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-
{[(trifluoromethyl)sulfonyl]amino}butanamide
trifluoroacetate (salt)
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(5-methyl-1,3-dioxo-1,3-
dihydro-2H-isoindol-2-yl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-hydroxypropyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[1-(hydroxymethyl)propyl]-5-methyl-N′,N′-
dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-3-{[(2-
hydroxyethyl)(propyl)amino]sulfonyl}-N-(3-
methoxybenzyl)propanamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-(benzylthio)-N-(3-ethylbenzyl)nicotinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1H-pyrazole-5-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-6-chloro-N-(3-ethylbenzyl)-3-methyl-2-oxo-2,3-
dihydro-1,3-benzoxazole-5-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1H-benzimidazole-2-
carboxamide
N 1 -[(2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyl]-N 1 -(3-
methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-6-hydroxy-4,7-dimethoxy-1-
benzofuran-5-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(4-methylcyclohexyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)[1,2,4]triazolo[4,3-
a]pyridine-6-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-oxo-4-(2-
thienyl)butanamide
N-[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(2-hydroxy-5-
methylphenyl)-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-phenoxybenzamide
4-[(aminocarbonyl)amino]-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-ethylbenzyl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1S)-1-(hydroxymethyl)-3-
(methylthio)propyl]-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-7-hydroxy-4-oxochromane-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1R)-1-(hydroxymethyl)propyl]-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-(1-methyl-3-phenylpropyl)-N′,N′-
dipropylisophthalamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(2,3-dihydro-1-benzofuran-
5-yl)-1,3-thiazole-4-carboxylate
(1R,2S)-2-amino-3-[3-(benzyloxy)phenyl]-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(4-chlorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-oxo-3-
(pentylamino)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(trifluoromethoxy)benzoate
(1R,2S)-2-amino-3-(3-fluoro-4-methylphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3-chloro-5-fluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-{[4-
(acetylamino)phenyl]amino}-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(1-cyanoethyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-oxo-4-[(5-phenyl-1,3,4-
thiadiazol-2-yl)amino]butanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-[3-
(trifluoromethoxy)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[2-(2-oxo-2-
pyrrolidin-1-ylethoxy)phenyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(4-chlorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (1,1-dioxidotetrahydro-2-
thienyl)acetate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
chlorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-hex-1-yn-1-ylnicotinate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methoxyisoxazole-5-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2,3-dimethyl-1H-indole-7-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3-chlorophenyl)-2-
hydroxy-4-oxobutanoate
(1R,2S)-2-amino-3-(3-fluoro-4-methoxyphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (1-methyl-1H-indol-3-
yl)(oxo)acetate
(1R,2S)-2-amino-3-(3-fluoro-4-methylphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(4-methylphenyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-fluoro-4-
methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [5-(4-methylphenyl)-2H-
tetrazol-2-yl]acetate
(1R,2S)-2-amino-3-(3,5-dichlorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-(2-
thienyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-methyl-3-phenylisoxazole-
4-carboxylate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
fluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(methylsulfonyl)acetyl]-
N-pentylglycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(4-
methoxybenzoyl)glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(2,6-
difluorobenzoyl)glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(1H-indol-3-yl)-4-
oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(5-benzyl-1,3,4-
thiadiazol-2-yl)amino]-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3-fluoro-4-
methoxyphenyl)-4-oxobutanoate
ethyl 4-{[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-({3-
[(dipropylamino)carbonyl]-5-
methylbenzoyl}oxy)butyl]amino}piperidine-1-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2-fluorobenzoyl)-1H-
pyrrole-2-carboxylate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
chlorophenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-[3-
(trifluoromethyl)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(4-hydroxyphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (4-morpholin-4-
ylphenyl)acetate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
[3-(trifluoromethoxy)phenyl]propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[benzyl(1-
cyclopropylethyl)amino]-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(2,5-dimethylbenzoyl)-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(2-methoxy-5-
methylphenyl)amino]-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (3-hydroxyphenyl)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-[hydroxy(2-
methylphenyl)methyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-(ethylthio)nicotinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[4-(2-furoyl)piperazin-1-
yl]-4-oxobutanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-fluoro-4-
methylphenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-oxoisoindoline-1-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(ethylthio)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl thieno[2,3-b]quinoline-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4-methyl-1,3-oxazol-2-
yl)benzoate hydrochloride
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
fluorophenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-[2-
furoyl(methyl)amino]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-(3-
methoxyphenyl)-4-oxobutanoate
(1R,2S)-2-amino-1-[(cycloheptylamino)methyl]-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-(4-
methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3-fluoro-5-hydroxyphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-hydroxy-1H-indole-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2,2-dimethylchromane-8-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-benzylpyrazine-2-
carboxylate 4-oxide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl {2-
[(dipropylamino)sulfonyl]ethyl}carbamate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-
(hydroxymethyl)-2-methylpropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-chloro-5-
fluorophenyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(4-methoxyphenyl)-4-
oxobutanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
hydroxyphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methyl-4-oxo-3,4-
dihydrophthalazine-1-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3,4-dihydro-2H-1,5-
benzodioxepine-7-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [4-(2,5-dioxopyrrolidin-1-
yl)phenoxy]acetate
(1R,2S)-2-amino-3-(2-furyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-methyl-4-oxo-3,4-
dihydrothieno[2,3-d]pyrimidine-6-carboxylate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3-chloro-5-fluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 5-(dipropylamino)-5-
oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-fluoro-2-hydroxyquinoline-
4-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-oxo-4-(2-thienyl)butanoate
(1R,2R)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(phenylthio)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R)-1-
(hydroxymethyl)-2-methylpropyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R,2S)-1-
(hydroxymethyl)-2-methylbutyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(phenoxymethyl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-[(2,4-
difluorophenyl)amino]-5-oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-[(4,6-dimethylpyrimidin-2-
yl)amino]-5-oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(3-methoxybenzoyl)-5-
methylbenzoate
(1R,2S)-2-amino-3-[3-(benzyloxy)phenyl]-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-dichlorophenyl)-4-
oxobutanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
[4-(methoxycarbonyl)phenyl]propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-[(4-acetylphenyl)amino]-5-
oxopentanoate
(1R,2S)-2-amino-3-[4-(benzyloxy)phenyl]-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2R)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(phenylthio)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-({2-
[(methylamino)carbonyl]phenyl}thio)propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-[(1-propylbutyl)thio]propanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(4-ethoxyphenyl)amino]-4-
oxobutanoate
(1R,2S)-2-amino-3-[3-(benzyloxy)-5-fluorophenyl]-1-
{[(3-methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[2-({[(3-
methoxyphenyl)amino]carbonyl}oxy)ethyl]amino}methyl)propyl
3-[(dipropylamino)carbonyl]-5-methylbenzoate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(2,3-dihydro-1-benzofuran-5-yl)-N-(3-
ethylbenzyl)-1,3-thiazole-4-carboxamide
N-{(2R,3S)-3-amino-4-[3-(benzyloxy)phenyl]-2-
hydroxybutyl}-N-(3-methoxybenzyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(4-chlorophenyl)-2-hydroxybutyl]-
3-[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-pentylmalonamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-
(trifluoromethoxy)benzamide
N-[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methylbutyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-N-
(3-ethylbenzyl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanamide
N′-[4-(acetylamino)phenyl]-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-ethylbenzyl)succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(1-cyanoethyl)-N-(3-ethylbenzyl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-(5-phenyl-1,3,4-
thiadiazol-2-yl)succinamide
N 1 -{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethoxy)phenyl]butyl}-N 1 -benzyl-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[2-(2-oxo-2-pyrrolidin-1-
ylethoxy)phenyl]-N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(4-chlorophenyl)-2-hydroxybutyl]-
N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(1,1-dioxidotetrahydro-2-thienyl)-N-(3-
ethylbenzyl)acetamide
N-[(2R,3S)-3-amino-4-(4-chlorophenyl)-2-hydroxybutyl]-
N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-hex-1-yn-1-ylnicotinamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-3-
[(dipropylamino)sulfonyl]-N-(3-methylbutyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-methoxyisoxazole-5-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2,3-dimethyl-1H-indole-7-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3-chlorophenyl)-N-(3-ethylbenzyl)-2-
hydroxy-4-oxobutanamide
N 1 -[(2R,3S)-3-amino-4-(3-fluoro-4-methoxyphenyl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(1-methyl-1H-indol-3-yl)-
2-oxoacetamide
N-[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-5-methyl-N-(3-methylbutyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-methylphenyl)butyl]-
3-[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N 1 -[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[5-(4-methylphenyl)-2H-
tetrazol-2-yl]acetamide
N-[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-N 1 -(3-
methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-methyl-3-phenylisoxazole-
4-carboxamide
N-[(2R,3S)-3-amino-4-(4-fluorophenyl)-2-hydroxybutyl]-
N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -[(methylsulfonyl)acetyl]-
N 2 -pentylglycinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(1H-indol-3-yl)-4-
oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(5-benzyl-1,3,4-thiadiazol-2-yl)-N-(3-
ethylbenzyl)succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(3-fluoro-4-
methoxyphenyl)-4-oxobutanamide
ethyl 4-([(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}amino)piperidine-1-carboxylate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(2-fluorobenzoyl)-1H-
pyrrole-2-carboxamide
N 1 -[(2R,3S)-3-amino-4-(4-chlorophenyl)-2-hydroxybutyl]-
N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N 1 -{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethyl)phenyl]butyl}-N 1 -(3-methylbutyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-hydroxyphenyl)butyl]-
5-methyl-N-(3-methylbutyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(4-morpholin-4-
ylphenyl)acetamide
N-{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethoxy)phenyl]butyl}-3-[(dipropylamino)sulfonyl]-
N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-benzyl-N′-(1-cyclopropylethyl)-N-(3-
ethylbenzyl)succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(2,5-dimethylbenzoyl)-N-(3-methoxybenzyl)-5-
methylbenzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-(2-methoxy-5-
methylphenyl)succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(3-hydroxyphenyl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-[hydroxy(2-methylphenyl)methyl]-N-(3-
methoxybenzyl)-5-methylbenzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-(ethylthio)nicotinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-[4-(2-furoyl)piperazin-1-
yl]-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-oxoisoindoline-1-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(ethylthio)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)thieno[2,3-b]quinoline-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(4-methyl-1,3-oxazol-2-
yl)benzamide hydrochloride
N 1 -[(2R,3S)-3-amino-4-(4-fluorophenyl)-2-hydroxybutyl]-
N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-(2-{[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]carbonyl}phenyl)-N-methyl-
2-furamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-(3-
methoxyphenyl)-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-cycloheptyl-5-methyl-N′,N′-
dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(4-methylphenyl)butyl]-
N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3-fluoro-5-hydroxyphenyl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-hydroxy-1H-indole-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2,2-dimethylchromane-8-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-6-benzyl-N-(3-ethylbenzyl)pyrazine-2-
carboxamide 4-oxide
2-({[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-methoxybenzyl)amino]carbonyl}amino)-N,N-
dipropylethanesulfonamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1R)-1-(hydroxymethyl)-2-methylpropyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-N-benzyl-3-
[(dipropylamino)sulfonyl]propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(4-methoxyphenyl)-4-
oxobutanamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(4-
hydroxyphenyl)butyl]-N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-methyl-4-oxo-3,4-
dihydrophthalazine-1-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3,4-dihydro-2H-1,5-
benzodioxepine-7-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-[4-(2,5-dioxopyrrolidin-1-yl)phenoxy]-N-(3-
ethylbenzyl)acetamide
N 1 -[(2R,3S)-3-amino-4-(2-furyl)-2-hydroxybutyl]-N 1 -(3-
methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-methyl-4-oxo-3,4-
dihydrothieno[2,3-d]pyrimidine-6-carboxamide
N 1 -[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3-chloro-5-fluorophenyl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-N′,N′-
dipropylpentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-6-fluoro-2-hydroxyquinoline-
4-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-oxo-4-(2-
thienyl)butanamide
N 3 -{[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-methoxybenzyl)amino]carbonyl}-N 1 ,N 1 -dipropyl-
β-alaninamide
N 1 -[(2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl]-N 1 -
(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1R)-1-(hydroxymethyl)-2-methylpropyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1R,2S)-1-(hydroxymethyl)-2-methylbutyl]-5-
methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(phenoxymethyl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(2,4-difluorophenyl)-N-(3-
ethylbenzyl)pentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(4,6-dimethylpyrimidin-2-yl)-N-(3-
ethylbenzyl)pentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(3-methoxybenzoyl)-N-(3-methoxybenzyl)-5-
methylbenzamide
N 1 -{(2R,3S)-3-amino-4-[3-(benzyloxy)phenyl]-2-
hydroxybutyl}-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-dichlorophenyl)-N-(3-ethylbenzyl)-4-
oxobutanamide
methyl 4-{(2S,3R)-2-amino-4-[{3-
[(dipropylamino)carbonyl]-5-methylbenzoyl}(3-
methoxybenzyl)amino]-3-hydroxybutyl}benzoate
N′-(4-acetylphenyl)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-
ethylbenzyl)pentanediamide
N-{(2R,3S)-3-amino-4-[4-(benzyloxy)phenyl]-2-
hydroxybutyl}-N-(3-methoxybenzyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyl]-N-(3-
methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
2-({3-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-3-oxopropyl}thio)-N-
methylbenzamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-3-[(1-propylbutyl)thio]propanamide
hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(4-ethoxyphenyl)-N-(3-
ethylbenzyl)succinamide
N 1 -{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
2-([(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]{3-[(dipropylamino)carbonyl]-5-
methylbenzoyl}amino)ethyl (3-methoxyphenyl)carbamate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(benzyloxy)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1S)-2-
hydroxy-1-methylethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(pentafluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(4-hydroxyphenyl)-4-
oxobutanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
[3-(trifluoromethyl)phenyl]propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(piperidin-3-
ylsulfonyl)benzoate dihydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-chloro-4-hydroxyquinoline-
2-carboxylate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(2-thienyl)propyl 5-(dipropylamino)-5-oxopentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-4-
methylpentyl 3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (6-oxo-3-phenylpyridazin-
1(6H)-yl)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-{4-
[(methylsulfonyl)amino]phenyl}propanoate
(1R,2S)-2-amino-3-(4-fluoro-3-methylphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
methylphenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 3-(2-chlorophenoxy)propanoate
(1R,2S)-2-amino-3-(4-fluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(4-chlorobenzoyl)-D-
alaninate
(1R,2S)-2-amino-3-[3-(benzyloxy)-5-fluorophenyl]-1-
{[(3-methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(4-methylphenyl)-4-
oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-oxo-4-{[3-
(trifluoromethyl)phenyl]amino}butanoate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (5-pyridin-2-yl-2H-tetrazol-
2-yl)acetate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(3-methylphenyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl isoxazole-5-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (3,5-
dimethoxyphenoxy)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2,5-dimethyl-1H-pyrrol-1-
yl)-3-hydroxybenzoate
(1R,2S)-2-amino-3-(3-bromophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 5-(dipropylamino)-5-
oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-{[5-(cyclopentylmethyl)-
1,3,4-thiadiazol-2-yl]amino}-4-oxobutanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-[3-
(trifluoromethyl)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (3-oxo-1,2-benzisothiazol-
2(3H)-yl)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-methyl-5-
(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]amino}methyl)propyl
3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-difluorophenyl)-4-
oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2-naphthyl)-4-
oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4,6-diethoxypyridine-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(5-methyl-1H-pyrrol-2-yl)-
4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-({[2-
(methylamino)ethyl]amino}sulfonyl)benzoate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-methyl-5-(4-
methylbenzoyl)benzoate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-
[(benzylamino)methyl]propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(piperazin-1-
ylsulfonyl)benzoate hydrochloride
(1R,2S)-2-amino-1-[({2-[4-
(aminosulfonyl)phenyl]ethyl}amino)methyl]-3-(3,5-
difluorophenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[2-hydroxy-
1-(hydroxymethyl)ethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(4-fluoro-3-methylphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(3-oxo-2,1-benzisothiazol-
1(3H)-yl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2,6-dihydroxypyrimidin-4-
yl)acetate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
[3-(trifluoromethyl)phenyl]propyl 5-(dipropylamino)-5-
oxopentanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
hydroxyphenyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-difluorophenyl)-2-
methyl-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-5-[(2-pyridin-2-
ylethyl)amino]pentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [2-(4-fluorophenyl)-1,3-
benzoxazol-5-yl]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(anilinocarbonyl)glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(2,6-
dimethoxybenzoyl)glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(1,3-dithian-2-yl)-3-
furoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-[2-oxo-2-
(propylamino)ethyl]benzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-
bromophenyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl 3-(2-fluorophenyl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-methylthiophene-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl [4-(benzyloxy)phenyl]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(5,7-
dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(1-acetyl-2,3-dihydro-1H-
indol-7-yl)amino]-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-[(3-acetylphenyl)amino]-5-
oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4-chlorophenoxy)-2-
hydroxypropanoate
N 3 -[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-
methoxybenzyl)-2-hydroxypropyl]-N 1 ,N 1 -dipropylbenzene-1,3,5-
tricarboxamide
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-
methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1H-indole-7-carboxylate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-(3-
methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(1,2,3-thiadiazol-4-
yl)benzoate
(1R,2S)-2-amino-3-[3-(benzyloxy)-5-fluorophenyl]-1-
{[(3-methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-(4-
methylphenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-[3-fluoro-5-
(trifluoromethyl)phenyl]propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [1-methyl-3-(methylthio)-1H-
indol-2-yl]acetate
(1R,2S)-2-amino-3-(3,5-dichlorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(2-{[4-(1,3-oxazol-5-
yl)phenyl]amino}-2-oxoethyl)thio]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2-furyl)-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(3-pyridin-2-yl-1,2,4-
oxadiazol-5-yl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [2-(acetylamino)-1,3-
thiazol-4-yl]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(4-methyl-4H-1,2,4-triazol-
3-yl)thio](phenyl)acetate
(1R,2S)-2-amino-3-(4-chlorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(1,3-benzothiazol-2-
yl)butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(3-chloro-4-
fluorophenyl)amino]-4-oxobutanoate
(1R,2S)-2-amino-3-[3-(benzyloxy)-5-fluorophenyl]-1-
{[(3-methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(2-oxo-2,3-
dihydroquinazolin-4-yl)thio]acetate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(benzyloxy)-N-(3-ethylbenzyl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1S)-2-hydroxy-1-methylethyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-
(pentafluorophenyl)butyl]-5-methyl-N′,N′-dipropyl-N-[3-
(trifluoromethyl)benzyl]isophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(4-hydroxyphenyl)-4-
oxobutanamide
N-{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethyl)phenyl]butyl}-3-[(dipropylamino)sulfonyl]-
N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(piperidin-3-
ylsulfonyl)benzamide dihydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-6-chloro-N-(3-ethylbenzyl)-4-hydroxyquinoline-
2-carboxamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-N-(3-
methoxybenzyl)-N′,N′-dipropylpentanediamide
N-[(2R,3S)-3-amino-2-hydroxy-5-methylhexyl]-N-(3-
methoxybenzyl)-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(6-oxo-3-phenylpyridazin-
1(6H)-yl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-{4-
[(methylsulfonyl)amino]phenyl}propanamide
N 1 -[(2R,3S)-3-amino-4-(4-fluoro-3-methylphenyl)-2-
hydroxybutyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-methylphenyl)butyl]-
N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(2-chlorophenoxy)-N-(3-
iodobenzyl)propanamide
N 1 -[(2R,3S)-3-amino-4-(4-fluorophenyl)-2-hydroxybutyl]-
N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(4-methylphenyl)-4-
oxobutanamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-oxo-4-{[3-
(trifluoromethyl)phenyl]amino}butanoate
N-[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(3-methylphenyl)butyl]-
3-[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)isoxazole-5-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(3,5-dimethoxyphenoxy)-N-(3-
ethylbenzyl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(3-
ethylbenzyl)-3-hydroxybenzamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-N-
(3-methoxybenzyl)-N′,N′-dipropylpentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-[5-(cyclopentylmethyl)-1,3,4-thiadiazol-2-
yl]-N-(3-ethylbenzyl)succinamide
N 1 -{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethyl)phenyl]butyl}-N 1 -benzyl-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(3-oxo-1,2-benzisothiazol-
2(3H)-yl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-methyl-N-[1-methyl-5-(pyrrolidin-1-
ylcarbonyl)-1H-pyrrol-3-yl]-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-difluorophenyl)-N-(3-ethylbenzyl)-4-
oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(2-naphthyl)-4-
oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4,6-diethoxy-N-(3-ethylbenzyl)pyridine-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(5-methyl-1H-pyrrol-2-yl)-
4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-({[2-
(methylamino)ethyl]amino}sulfonyl)benzamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-3-methyl-5-(4-
methylbenzoyl)benzamide
N-[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(piperazin-1-
ylsulfonyl)benzamide hydrochloride
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-{2-[4-(aminosulfonyl)phenyl]ethyl}-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-5-methyl-
N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-4-(4-fluoro-3-methylphenyl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(3-oxo-2,1-benzisothiazol-
1(3H)-yl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(2,6-dihydroxypyrimidin-4-yl)-N-(3-
ethylbenzyl)acetamide
N-{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethyl)phenyl]butyl}-N-(3-methoxybenzyl)-N′,N′-
dipropylpentanediamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-hydroxyphenyl)butyl]-
N-benzyl-3-[(dipropylamino)sulfonyl]propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-difluorophenyl)-N-(3-ethylbenzyl)-2-
methyl-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-(2-pyridin-2-
ylethyl)pentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[2-(4-fluorophenyl)-1,3-
benzoxazol-5-yl]acetamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -(anilinocarbonyl)-N 1 -(3-
ethylbenzyl)glycinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(1,3-dithian-2-yl)-N-(3-ethylbenzyl)-3-
furamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[2-oxo-2-
(propylamino)ethyl]benzamide
N-[(2R,3S)-3-amino-4-(3-bromophenyl)-2-hydroxybutyl]-N-
benzyl-3-[(dipropylamino)sulfonyl]propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(2-fluorophenyl)-N-(3-iodobenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-methylthiophene-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-[4-(benzyloxy)phenyl]-N-(3-
iodobenzyl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-[(5,7-dimethyl[1,2,4]triazolo[4,3-
a]pyrimidin-3-yl)thio]-N-(3-ethylbenzyl)acetamide
N′-(1-acetyl-2,3-dihydro-1H-indol-7-yl)-N-[(2R,3S)-3-
amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-N-(3-
ethylbenzyl)succinamide
N′-(3-acetylphenyl)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-
ethylbenzyl)pentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(4-chlorophenoxy)-N-(3-ethylbenzyl)-2-
hydroxypropanamide
N 3 -[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-
methoxybenzyl)-2-hydroxypropyl]-N 1 ,N 1 -dipropylbenzene-1,3,5-
tricarboxamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(3-methylphenyl)butyl]-
N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1H-indole-7-carboxamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(3-methylphenyl)butyl]-
N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(1,2,3-thiadiazol-4-
yl)benzamide
N-{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-N-
(3-ethylbenzyl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-methylphenyl)butyl]-
5-methyl-N-(3-methylbutyl)-N′,N′-dipropylisophthalamide
N-{(2R,3S)-3-amino-4-[3-fluoro-5-
(trifluoromethyl)phenyl]-2-hydroxybutyl}-N-benzyl-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[1-methyl-3-(methylthio)-
1H-indol-2-yl]acetamide
N-[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-5-methyl-N-(3-methylbutyl)-N′,N′-
dipropylisophthalamide
2-({2-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-2-oxoethyl}thio)-N-[4-
(1,3-oxazol-5-yl)phenyl]acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(2-furyl)-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(3-pyridin-2-yl-1,2,4-
oxadiazol-5-yl)propanamide
2-[2-(acetylamino)-1,3-thiazol-4-yl]-N-[(2R,3S)-3-
amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-N-(3-
ethylbenzyl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(4-methyl-4H-1,2,4-
triazol-3-yl)thio]-2-phenylacetamide
N-[(2R,3S)-3-amino-4-(4-chlorophenyl)-2-hydroxybutyl]-
5-methyl-N-(3-methylbutyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(1,3-benzothiazol-2-yl)-N-(3-
ethylbenzyl)butanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(3-chloro-4-fluorophenyl)-N-(3-
ethylbenzyl)succinamide
N-{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-5-methyl-N-(3-methylbutyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(2-oxo-2,3-
dihydroquinazolin-4-yl)thio]acetamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-methyl-5-(2-
methylbenzoyl)benzoate
(1R,2S)-2-amino-3-(4-hydroxyphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 5-(dipropylamino)-5-
oxopentanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(4-
methylphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-propoxybenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1-methyl-1H-indole-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-chloro-2-(3-methyl-4H-
1,2,4-triazol-4-yl)benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-difluorophenyl)-2-
methoxy-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [3-(2-thienyl)-1H-pyrazol-1-
yl]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-anilino-5-oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2-thioxo-1,3-benzothiazol-
3(2H)-yl)acetate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-
cyclohexylpropyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
(4-methoxyphenyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (3-hydroxy-4-
methylphenyl)acetate
(1R,2S)-2-amino-3-[3-fluoro-5-(trifluoromethyl)phenyl]-
1-{[(3-methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 7-fluoro-4H-imidazo[5,1-
c][1,4]benzoxazine-3-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-dihydro-2H-1,5-
benzodioxepin-7-yl)-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 1-benzofuran-3-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(3,4-
dichlorophenyl)amino]-3-oxopropanoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-[3-fluoro-5-
(trifluoromethyl)phenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R)-2-
hydroxy-1-methylethyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-
methylphenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-5-(pyridin-3-
ylamino)pentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-methyl-4-oxo-4H-chromene-
6-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl ({2-[(5-methylisoxazol-3-
yl)amino]-2-oxoethyl}thio)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-(1H-
imidazol-1-yl)propyl]amino}methyl)propyl 3-
[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-[3-fluoro-5-(trifluoromethyl)phenyl]-
1-{[(3-methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(4-hydroxyphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-(2-
thienyl)propyl 3-[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(2,2-
dimethylpropanoyl)amino]-2-hydroxybenzoate
(1R,2S)-2-amino-3-(3-methoxyphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(4-fluorophenyl)-1-{[(3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-{[(3-
methoxybenzyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-[3-
(trifluoromethyl)phenyl]propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-(2-furoylamino)hexanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(1-phenyl-4,5-dihydro-1H-
tetrazol-5-yl)thio]acetate
(1S,2S)-2-amino-3-phenyl-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-{[(3-
methoxybenzyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-dihydro-2H-chromen-6-
yl)-4-oxobutanoate
(1R,2S)-2-amino-3-(3-methoxyphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3-fluoro-4-methylphenyl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 5-(dipropylamino)-5-
oxopentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl indolizine-2-carboxylate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-[3-
(trifluoromethoxy)phenyl]propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl nicotinate 1-oxide
(1R,2S)-2-amino-3-[3-(benzyloxy)-5-fluorophenyl]-1-
{[(3-methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
iodobenzyl)amino]methyl}propyl [(aminocarbonyl)oxy]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2,3-dihydro-1H-
cyclopenta[b]quinoline-9-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-methyl-1H-pyrazole-5-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-(benzoylamino)pentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-
[(methoxymethyl)thio]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(1,3-benzothiazol-2-yl)-3-
methoxypropanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-
{[(methylamino)carbonyl]amino}-3-(3-thienyl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-pyridin-2-ylthiophene-2-
carboxylate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-[3-
(benzyloxy)-5-fluorophenyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (5,6-dimethyl-2,4-dioxo-
1,2,3,4-tetrahydropyridin-3-yl)acetate
(1R,2S)-2-amino-3-(3-fluoro-4-methoxyphenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(dipropylamino)carbonyl]-
5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-isobutyl-1,3-
dioxoisoindoline-5-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-(acetylamino)-2-furoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(4-
methoxyphenyl)acetyl]glycinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl isoquinoline-4-carboxylate
(1R,2S)-2-amino-3-[3-(benzyloxy)phenyl]-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (4-hydroxy-3-
methoxyphenyl)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(4-phenyl-4H-1,2,4-triazol-
3-yl)thio]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (3,5-dimethoxyphenyl)acetate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(3-
methoxyphenyl)propyl 3-[(dipropylamino)carbonyl]-5-
methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2-ethyl-4H-
[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)acetate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(2-
furyl)propyl 3-[(dipropylamino)carbonyl]-5-methylbenzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 7-chloro-1-benzofuran-2-
carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(1,3-dioxo-1,3-dihydro-2H-
isoindol-2-yl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-oxo-2H-1,3-benzoxazin-
3(4H)-yl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (pyrimidin-2-ylthio)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-{[3-(aminocarbonyl)-
4,5,6,7-tetrahydro-1-benzothien-2-yl]amino}-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(5-phenyl-1,3,4-oxadiazol-
2-yl)thio]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl quinoline-6-carboxylate
(1R,2S)-2-amino-1-[(benzylamino)methyl]-3-(2-
furyl)propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(2,3-dihydro-1,4-
benzodioxin-6-yl)-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(1H-indol-3-yl)-1H-
pyrazole-5-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-
{[(methylamino)carbonothioyl]amino}benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 6-chloronicotinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3-hydroxyphenyl)-4-
oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (phthalazin-1-ylthio)acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl [(1-oxidopyridin-2-
yl)thio]acetate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(acetylamino)-5-fluoro-1H-
indole-2-carboxylate
(1S,2S)-2-amino-3-phenyl-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-{[(3-
chlorobenzyl)amino]sulfonyl}benzoate
(1R,2S)-2-amino-3-[4-(benzyloxy)phenyl]-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-
[(benzylamino)methyl]propyl 3-(aminocarbonyl)-5-
[(dipropylamino)carbonyl]benzoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-(3,4-dichlorophenyl)-2-
hydroxy-3-methyl-4-oxobutanoate
(1R,2S)-2-amino-1-{[(3-methylbutyl)amino]methyl}-3-[3-
(trifluoromethoxy)phenyl]propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(5-methyl-1,3,4-
thiadiazol-2-yl)amino]-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2-ethyl-1H-benzimidazol-1-
yl)acetate
(1R,2S)-2-amino-3-(1,3-benzodioxol-5-yl)-1-{[(3-
methoxybenzyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-oxo-1,3-benzoxazol-
3(2H)-yl)propanoate
(1R,2S)-2-amino-3-(3,5-dichlorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-
[(dipropylamino)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-[(6-methylpyridin-2-
yl)amino]-4-oxobutanoate
4-((1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl) 3-ethyl (4R)-1,3-
oxazolidine-3,4-dicarboxylate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-3-methyl-5-(2-
methylbenzoyl)benzamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-hydroxyphenyl)butyl]-
N-(3-methoxybenzyl)-N′,N′-dipropylpentanediamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(4-methylphenyl)butyl]-
N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-propoxybenzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1-methyl-1H-indole-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-5-chloro-N-(3-ethylbenzyl)-2-(3-methyl-4H-
1,2,4-triazol-4-yl)benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-difluorophenyl)-N-(3-ethylbenzyl)-2-
methoxy-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[3-(2-thienyl)-1H-pyrazol-
1-yl]acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-phenylpentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(2-thioxo-1,3-
benzothiazol-3(2H)-yl)acetamide
N-[(2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyl]-N-
benzyl-5-methyl-N′,N′-dipropylisophthalamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(4-
methoxyphenyl)butyl]-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(3-hydroxy-4-
methylphenyl)acetamide
N-{(2R,3S)-3-amino-4-[3-fluoro-5-
(trifluoromethyl)phenyl]-2-hydroxybutyl}-5-methyl-N-(3-
methylbutyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-7-fluoro-4H-imidazo[5,1-
c][1,4]benzoxazine-3-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-N-
(3-ethylbenzyl)-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-1-benzofuran-3-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N′-(3,4-dichlorophenyl)-N-(3-
ethylbenzyl)malonamide
N 1 -{(2R,3S)-3-amino-4-[3-fluoro-5-
(trifluoromethyl)phenyl]-2-hydroxybutyl}-N 1 -benzyl-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[(1R)-2-hydroxy-1-methylethyl]-5-methyl-
N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(3-methylphenyl)butyl]-
N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-pyridin-3-
ylpentanediamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-methyl-4-oxo-4H-chromene-
6-carboxylate
2-({2-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-2-oxoethyl}thio)-N-(5-
methylisoxazol-3-yl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-[3-(1H-imidazol-1-yl)propyl]-5-methyl-N′,N′-
dipropylisophthalamide
N-{(2R,3S)-3-amino-4-[3-fluoro-5-
(trifluoromethyl)phenyl]-2-hydroxybutyl}-3-
[(dipropylamino)sulfonyl]-N-(3-methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(4-hydroxyphenyl)butyl]-
3-[(dipropylamino)sulfonyl]-N-(3-methylbutyl)propanamide
N-[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-5-methyl-N-(3-methylbutyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(2-thienyl)butyl]-3-
[(dipropylamino)sulfonyl]-N-(3-methylbutyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-[(2,2-dimethylpropanoyl)amino]-N-(3-
ethylbenzyl)-2-hydroxybenzamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(3-methoxyphenyl)butyl]-
5-methyl-N-(3-methylbutyl)-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(4-fluorophenyl)-2-hydroxybutyl]-
3-{[(3-methoxybenzyl)amino]sulfonyl}-N-[3-
(trifluoromethyl)benzyl]benzamide
N-{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethyl)phenyl]butyl}-5-methyl-N-(3-methylbutyl)-
N′,N′-dipropylisophthalamide
N-{6-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-6-oxohexyl}-2-furamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(1-phenyl-4,5-dihydro-1H-
tetrazol-5-yl)thio]acetamide
N-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-3-{[(3-
methoxybenzyl)amino]sulfonyl}-N-[3-
(trifluoromethyl)benzyl]benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-dihydro-2H-chromen-6-yl)-N-(3-
ethylbenzyl)-4-oxobutanamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-(3-
methoxyphenyl)butyl]-N 1 -(3-methylbutyl)-N 3 ,N 3 -
dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3-fluoro-4-methylphenyl)-2-
hydroxybutyl]-N-(3-methoxybenzyl)-N′,N′-
dipropylpentanediamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)indolizine-2-carboxamide
N-{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethoxy)phenyl]butyl}-N-benzyl-5-methyl-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)nicotinamide 1-oxide
N-{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-3-[(dipropylamino)sulfonyl]-N-(3-
methylbutyl)propanamide
2-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-iodobenzyl)amino]-2-oxoethyl carbamate
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2,3-dihydro-1H-
cyclopenta[b]quinoline-9-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-methyl-1H-pyrazole-5-
carboxamide
N-{5-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-5-oxopentyl}benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-
[(methoxymethyl)thio]benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(1,3-benzothiazol-2-yl)-N-(3-ethylbenzyl)-3-
methoxypropanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-
{[(methylamino)carbonyl]amino}-3-(3-thienyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-pyridin-2-ylthiophene-2-
carboxamide
N 1 -{(2R,3S)-3-amino-4-[3-(benzyloxy)-5-fluorophenyl]-2-
hydroxybutyl}-N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(5,6-dimethyl-2,4-dioxo-1,2,3,4-
tetrahydropyridin-3-yl)-N-(3-ethylbenzyl)acetamide
N-[(2R,3S)-3-amino-4-(3-fluoro-4-methoxyphenyl)-2-
hydroxybutyl]-5-methyl-N-(3-methylbutyl)-N′,N′-
dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-isobutyl-1,3-
dioxoisoindoline-5-carboxamide
5-(acetylamino)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-ethylbenzyl)-2-furamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -[(4-
methoxyphenyl)acetyl]glycinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)isoquinoline-4-carboxamide
N 1 -{(2R,3S)-3-amino-4-[3-(benzyloxy)phenyl]-2-
hydroxybutyl}-N 1 -(3-methylbutyl)-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(4-hydroxy-3-
methoxyphenyl)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(4-phenyl-4H-1,2,4-
triazol-3-yl)thio]acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(3,5-dimethoxyphenyl)-N-(3-
ethylbenzyl)acetamide
N-[(2R,3S)-3-amino-2-hydroxy-4-(3-methoxyphenyl)butyl]-
N-benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(2-ethyl-4H-
[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)acetamide
N-[(2R,3S)-3-amino-4-(2-furyl)-2-hydroxybutyl]-N-
benzyl-5-methyl-N′,N′-dipropylisophthalamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-7-chloro-N-(3-ethylbenzyl)-1-benzofuran-2-
carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-
(3-ethylbenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(2-oxo-2H-1,3-benzoxazin-
3(4H)-yl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(pyrimidin-2-
ylthio)acetamide
N′-[3-(aminocarbonyl)-4,5,6,7-tetrahydro-1-benzothien-
2-yl]-N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(5-phenyl-1,3,4-
oxadiazol-2-yl)thio]acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)quinoline-6-carboxamide
N 1 -[(2R,3S)-3-amino-4-(2-furyl)-2-hydroxybutyl]-N 1 -
benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(3-
ethylbenzyl)-4-oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(1H-indol-3-yl)-1H-
pyrazole-5-carboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-
{[(methylamino)carbonothioyl]amino}benzamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-6-chloro-N-(3-ethylbenzyl)nicotinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-(3-hydroxyphenyl)-4-
oxobutanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-(phthalazin-1-
ylthio)acetamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-[(1-oxidopyridin-2-
yl)thio]acetamide
3-(acetylamino)-N-[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N-(3-ethylbenzyl)-5-fluoro-
1H-indole-2-carboxamide
N-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-3-{[(3-
chlorobenzyl)amino]sulfonyl}-N-[3-
(trifluoromethyl)benzyl]benzamide
N 1 -{(2R,3S)-3-amino-4-[4-(benzyloxy)phenyl]-2-
hydroxybutyl}-N 1 -(3-methoxybenzyl)-N 3 ,N 3 -dipropylbenzene-
1,3,5-tricarboxamide
N 1 -[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-N 1 -benzyl-N 3 ,N 3 -dipropylbenzene-1,3,5-
tricarboxamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(3,4-dichlorophenyl)-N-(3-ethylbenzyl)-2-
hydroxy-3-methyl-4-oxobutanamide
N-{(2R,3S)-3-amino-2-hydroxy-4-[3-
(trifluoromethoxy)phenyl]butyl}-3-[(dipropylamino)sulfonyl]-
N-(3-methylbutyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-(5-methyl-1,3,4-
thiadiazol-2-yl)succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-2-(2-ethyl-1H-benzimidazol-1-yl)-N-(3-
ethylbenzyl)acetamide
N-[(2R,3S)-3-amino-4-(1,3-benzodioxol-5-yl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-3-(2-oxo-1,3-benzoxazol-
3(2H)-yl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-dichlorophenyl)-2-
hydroxybutyl]-3-[(dipropylamino)sulfonyl]-N-(3-
methylbutyl)propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-N′-(6-methylpyridin-2-
yl)succinamide
ethyl (4R)-4-{[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-
2-hydroxybutyl](3-ethylbenzyl)amino]carbonyl}-1,3-
oxazolidine-3-carboxylate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfinyl)-N-
(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl S-butyl-N-(methoxycarbonyl)-
D-cysteinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(4,4,4-trifluorobutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(4,4,4-trifluorobutyl)sulfinyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-S-
(4,4,4-trifluorobutyl)-D-cysteinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(2,2,2-
trifluoroethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(2-
cyanoethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-{[(3R)-
pyrrolidin-3-yloxy]carbonyl}-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-{[(3S)-
tetrahydrofuran-3-yloxy]carbonyl}-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-{[2-
(acetylamino)ethoxy]carbonyl}-3-(butylsulfonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
[(pyridin-3-ylmethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
[(pyridin-4-ylmethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl 3-(butylsulfonyl)-N-(methoxycarbonyl)-
D-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl 3-(butylsulfonyl)-N-[(2-
cyanoethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
(butylsulfonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl N-[(2-cyanoethoxy)carbonyl]-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl N-{[2-(acetylamino)ethoxy]carbonyl}-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl N-(methoxycarbonyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-{[2-(diethylamino)-2-
oxoethoxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(methoxycarbonyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(isopropoxycarbonyl)-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-
[(cyclopropylmethoxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-
D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(allyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(2-cyanoethoxy)carbonyl]-
3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-{[2-
(acetylamino)ethoxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[(pyridin-3-ylmethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[(pyridin-4-ylmethoxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-2-
{[(benzyloxy)carbonyl]amino}-4-(methylsulfonyl)butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
(butylsulfonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
(butylsulfonyl)-L-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R)-2-
hydroxy-1-phenylethyl]amino}methyl)propyl N-
[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1R)-2-
methoxy-1-phenylethyl]amino}methyl)propyl N-
[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[(1S)-2-
methoxy-1-phenylethyl]amino}methyl)propyl N-
[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl N-
[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[(prop-2-yn-1-yloxy)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(2-
methoxyethoxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[(3R)-1-
acetylpyrrolidin-3-yl]oxy}carbonyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-L-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]-L-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl N-
[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl N-[(benzyloxy)carbonyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-{[(cyclopropylmethyl)amino]methyl}-3-
(3,5-difluorophenyl)propyl N-[(benzyloxy)carbonyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylphenyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({2-[3-
(trifluoromethyl)phenyl]ethyl}amino)methyl]propyl N-
[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[(pyridin-3-ylmethoxy)carbonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[(3R)-tetrahydrofuran-3-yloxy]carbonyl}alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-[(1-propylbutyl)sulfonyl]-N-{[(3S)-
tetrahydrofuran-3-yloxy]carbonyl}alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[(3R)-1-
acetylpyrrolidin-3-yl]oxy}carbonyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[(3R)-pyrrolidin-3-yloxy]carbonyl}alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[(3R)-1-
benzylpyrrolidin-3-yl]oxy}carbonyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[(3R)-1,1-
dioxidotetrahydro-3-thienyl]oxy}carbonyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[(3R)-tetrahydro-3-thienyloxy]carbonyl}alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-
[(cyclopentyloxy)carbonyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(cyclohexyloxy)carbonyl]-
3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl 3-[(1-propylbutyl)sulfonyl]-N-
[(tetrahydro-2H-pyran-4-yloxy)carbonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[1-
(methylsulfonyl)piperidin-4-yl]oxy}carbonyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-{[(1-acetylpiperidin-4-
yl)oxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[(2R)-5-oxopyrrolidin-2-
yl]methoxy}carbonyl)-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-({[(2S)-5-oxopyrrolidin-2-
yl]methoxy}carbonyl)-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(2-
methoxyethoxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(benzyloxy)carbonyl]-3-
(butylsulfonyl)alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[(benzyloxy)carbonyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-
methoxybenzyl)amino]propyl}-2-hydroxy-4-
(phenylsulfonyl)butanamide hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N 2 -[(benzyloxy)carbonyl]-
N 5 ,N 5 -dipropyl-L-glutaminate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N 2 -[(benzyloxy)carbonyl]-
N 5 ,N 5 -dipropyl-D-glutaminate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-(3,3,3-
trifluoropropanoyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(trifluoroacetyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-acetyl-3-(butylsulfonyl)-
D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
isonicotinoyl-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(cyclopropylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl β-alanyl-3-(butylsulfonyl)-
D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl glycyl-3-(butylsulfonyl)-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N,N-dimethylglycyl-3-
(butylsulfonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N,N-dimethyl-β-alanyl-3-
(butylsulfonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N
(methoxyacetyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(pyridin-3-ylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(2,4-
dimethyl-1,3-thiazol-5-yl)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-{[3-
(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(3-
methyl-1H-pyrazol-5-yl)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-(1H-
imidazol-4-ylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5-hydroxy-2-
[(methoxycarbonyl)amino]nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(6-
hydroxypyridin-3-yl)carbonyl]-D-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl 3-(butylsulfonyl)-N-(pyridin-3-
ylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl N-acetyl-3-(butylsulfonyl)-
D-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl N-(cyclopropylcarbonyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl N-acetyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-isonicotinoyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(5-bromopyridin-3-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(5-chloropyridin-3-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-fluorobenzoyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(5-methylpyridin-3-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-phenylglycyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-{[3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(3-methyl-1H-pyrazol-5-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(1,3-thiazol-4-ylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(1-acetylpiperidin-4-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[4-(acetylamino)butanoyl]-
3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-acetyl-β-alanyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(chloroacetyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(methoxyacetyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-methoxypropanoyl)-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(2,2-dimethylpropanoyl)-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-isobutyryl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-butyryl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-acetyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-[(1-
propylbutyl)sulfonyl]-N-(pyridin-3-ylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl N-isonicotinoyl-
3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl N-(3-
hydroxybenzoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(pyridin-3-ylcarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-hydroxybenzoyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(cyclopropylcarbonyl)-3-
[(1-propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-propionyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(pyridin-3-ylcarbonyl)alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl N-(3-
hydroxybenzoyl)-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl N-isonicotinoyl-
3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(6-oxo-1,4,5,6-
tetrahydropyridazin-3-yl)carbonyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-D-prolyl-3-[(1-
propylbutyl)sulfonyl]alaninate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 5-oxo-L-prolyl-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[3-(4-oxo-2-thioxo-1,3-
thiazolidin-3-yl)propanoyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(piperidin-4-ylcarbonyl)-
3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(2,4-dimethyl-1,3-
thiazol-5-yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-{[2-methyl-4-
(trifluoromethyl)-1,3-thiazol-5-yl]carbonyl}-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(3,5-dimethylisoxazol-4-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(3-methyl-1H-pyrazol-5-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(1H-pyrazol-4-ylcarbonyl)alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(1H-imidazol-5-
ylcarbonyl)-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(1H-imidazol-4-ylacetyl)-
3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(pyrazin-2-ylcarbonyl)alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(2,6-
dihydroxyisonicotinoyl)-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(6-hydroxypyridin-3-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-[(6-chloropyridin-3-
yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-isonicotinoyl-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(pyridin-3-ylcarbonyl)alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(pyridin-2-ylcarbonyl)alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(1H-indol-6-ylcarbonyl)-3-
[(1-propylbutyl)sulfonyl]alaninate hydrochloride
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-(3,4,5-trimethoxybenzoyl)alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(2-methylbenzoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-hydroxybenzoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-methylbenzoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-ethylbenzoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-chlorobenzoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[4-(trifluoromethyl)benzoyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(4-methoxybenzoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[4-(trifluoromethyl)benzoyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(cyclohexylcarbonyl)-3-
[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-benzoyl-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl N-benzoyl-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(phenylacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(3-phenylpropanoyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(benzoylamino)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-(cyclopropylacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[(methylsulfonyl)acetyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[(methylthio)acetyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[4-(methylamino)-4-oxobutanoyl]-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-(methylsulfonyl)glycyl-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-acetyl-3-(phenylsulfonyl)alaninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-5-oxo-
5-piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-{[(benzyloxy)carbonyl]amino}-5-oxo-5-
piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-[(3-ethoxy-3-oxopropanoyl)amino]-5-oxo-
5-piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N 2 -(4-methoxy-4-oxobutanoyl)-N 5 ,N 5 -dipropyl-D-
glutaminate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-[(4-methoxy-4-oxobutanoyl)amino]-5-oxo-
5-piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-[(5-methoxy-5-oxopentanoyl)amino]-5-oxo-
5-piperidin-1-ylpentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-(acetyloxy)-3-
(butylsulfonyl)propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl S-butyl-D-cysteinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfinyl)-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-L-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-(butylsulfonyl)-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-[(1-
propylbutyl)sulfonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
L-alaninate
(1R,2S)-2-amino-1-[(cyclopropylamino)methyl]-3-(3,5-
difluorophenyl)propyl 3-[(1-propylbutyl)sulfonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
methylbutyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(phenoxyacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-{[(5-chloro-2-
thienyl)thio]peroxy}-3-[(1-propylbutyl)sulfonyl]alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl N-(phenylsulfonyl)-3-[(1-
propylbutyl)sulfonyl]alaninate
(1R,2S)-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}-2-(methylamino)propyl N-
[(benzylamino)carbonyl]-3-[(1-propylbutyl)sulfonyl]alaninate
4-{[(1R,2S)-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}-2-(methylamino)propyl]oxy}-4-oxo-
3-{[(1-propylbutyl)sulfonyl]methyl}butanoic acid
4-[((1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-
3-phenylpropyl)oxy]-3-{[(3-methylbutyl)sulfonyl]methyl}-4-
oxobutanoic acid
1-((1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-
3-phenylpropyl) 4-methyl 2-{[(3-
methylbutyl)sulfonyl]methyl}succinate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 4-amino-2-{[(3-methylbutyl)sulfonyl]methyl}-4-
oxobutanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 4-(methylamino)-2-{[(3-
methylbutyl)sulfonyl]methyl}-4-oxobutanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 4-(dimethylamino)-2-{[(3-
methylbutyl)sulfonyl]methyl}-4-oxobutanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
(1R,2R)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-(ethylsulfonyl)-2-
{[(isobutylsulfonyl)amino]methyl}propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-(ethylthio)-2-
{[(isobutylsulfonyl)amino]methyl}propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2S)-2-{[(3-methylbutyl)sulfonyl]amino}-4-
(methylsulfonyl)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[(3-methylbutyl)sulfonyl]-L-methioninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 3-(acetylthio)-2-{[(3-
methylbutyl)sulfonyl]methyl}propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-3-[(1-propylbutyl)sulfonyl]propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-3-[(3-methylbutyl)sulfonyl]propanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-3-[(3-
methoxyphenyl)sulfonyl]propanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 2-hydroxy-4-
(phenylsulfonyl)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-4-[(3-methylbutyl)sulfonyl]butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 4-[(3-methylbutyl)sulfonyl]-2-phenoxybutanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-(3-methoxyphenoxy)-4-[(3-
methylbutyl)sulfonyl]butanoate
3-{1-{[((1R,2S)-2-amino-1-{[(3-
methoxybenzyl)amino]methyl}-3-phenylpropyl)oxy]carbonyl}-3-
[(3-methylbutyl)sulfonyl]propoxy}benzoic acid
methyl 3-{1-{[((1R,2S)-2-amino-1-{[(3-
methoxybenzyl)amino]methyl}-3-phenylpropyl)oxy]carbonyl}-3-
[(3-methylbutyl)sulfonyl]propoxy}benzoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-4-(phenylsulfonyl)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-hydroxy-4-(phenylthio)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-methoxy-4-(phenylsulfonyl)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-methoxy-4-(phenylthio)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 4-(phenylsulfonyl)-2-propoxybutanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl 2-(benzyloxy)-4-(phenylsulfonyl)butanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl N-[(benzyloxy)carbonyl]methioninate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2S)-2-amino-5-oxo-5-piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2S)-2-[(2-methoxy-2-oxoethyl)amino]-5-oxo-5-
piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-amino-5-oxo-5-piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-[(2-ethoxy-2-oxoethyl)amino]-5-oxo-5-
piperidin-1-ylpentanoate
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-[(4-ethoxy-4-oxobutyl)amino]-5-oxo-5-
piperidin-1-ylpentanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-2-
[(methoxycarbonyl)amino]-4-oxooctanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-butyl-N-(methoxycarbonyl)-
D-homoserinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-butyl-1,3-dioxolan-2-
yl)-N-(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-butyl-1,3-dioxan-2-yl)-
N-(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4,4-difluoro-2-
[(methoxycarbonyl)amino]octanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4-fluoro-2-
[(methoxycarbonyl)amino]octanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-2-
[(methoxycarbonyl)amino]-5-oxononanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5-hydroxy-2-
[(methoxycarbonyl)amino]nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4-(2-butyl-1,3-
dioxolan-2-yl)-2-[(methoxycarbonyl)amino]butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4-(2-butyl-1,3-dioxan-
2-yl)-2-[(methoxycarbonyl)amino]butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5-fluoro-2-
[(methoxycarbonyl)amino]nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5,5-difluoro-2-
[(methoxycarbonyl)amino]nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethynylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({1-[3-
(trifluoromethyl)phenyl]cyclopropyl}amino)methyl]propyl 3-
(butylsulfonyl)-N-(methoxycarbonyl)-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethynylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(3-
methyl-1H-pyrazol-5-yl)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(3-methyl-1H-pyrazol-5-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(3-methyl-1H-pyrazol-5-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(3-methyl-1H-pyrazol-5-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({1-[3-
(trifluoromethyl)phenyl]cyclopropyl}amino)methyl]propyl 3-
(butylsulfonyl)-N-[(3-methyl-1H-pyrazol-5-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-2-
{[(methylamino)carbonyl]amino}-4-oxooctanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 4-butyl-N-
[(methylamino)carbonyl]-D-homoserinate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-butyl-1,3-dioxolan-2-
yl)-N-[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-butyl-1,3-dioxan-2-yl)-
N-[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4,4-difluoro-2-
{[(methylamino)carbonyl]amino}octanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4-fluoro-2-
{[(methylamino)carbonyl]amino}octanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-2-
{[(methylamino)carbonyl]amino}-5-oxononanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5-hydroxy-2-
{[(methylamino)carbonyl]amino}nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4-(2-butyl-1,3-
dioxolan-2-yl)-2-{[(methylamino)carbonyl]amino}butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-4-(2-butyl-1,3-dioxan-
2-yl)-2-{[(methylamino)carbonyl]amino}butanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5-fluoro-2-
{[(methylamino)carbonyl]amino}nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl (2R)-5,5-difluoro-2-
{[(methylamino)carbonyl]amino}nonanoate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethynylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-
[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({1-[3-
(trifluoromethyl)phenyl]cyclopropyl}amino)methyl]propyl 3-
(butylsulfonyl)-N-[(methylamino)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethynylbenzyl)amino]methyl}propyl 3-(butylsulfonyl)-N-[(4-
methyl-1H-pyrazol-1-yl)carbonyl]-D-alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[3-
(trifluoromethyl)benzyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(4-methyl-1H-pyrazol-1-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(4-methyl-1H-pyrazol-1-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-({[1-(3-
ethynylphenyl)cyclopropyl]amino}methyl)propyl 3-
(butylsulfonyl)-N-[(4-methyl-1H-pyrazol-1-yl)carbonyl]-D-
alaninate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-[({1-[3-
(trifluoromethyl)phenyl]cyclopropyl}amino)methyl]propyl 3-
(butylsulfonyl)-N-[(4-methyl-1H-pyrazol-1-yl)carbonyl]-D-
alaninate
benzyl [(1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-3-
(methylsulfonyl)propyl]carbamate
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-[(1-propylbutyl)sulfonyl]-
N-[(tetrahydro-2H-pyran-4-yloxy)carbonyl]alaninate
S-(3-[[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](3-
methoxybenzyl)amino]-2-{[(3-methylbutyl)sulfonyl]methyl}-3-
oxopropyl) ethanethioate
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-2-(3-methoxyphenoxy)-4-[(3-
methylbutyl)sulfonyl]butanamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-N 2 -(3,3,3-
trifluoropropanoyl)-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-N 2 -
(trifluoroacetyl)-D-alaninamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-methoxy-
N-(3-methoxybenzyl)-4-(phenylthio)butanamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 2 -(cyclopropylcarbonyl)-N 1 -
(3-ethylbenzyl)-D-alaninamide
β-alanyl-N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-D-
alaninamide
glycyl-N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-D-
alaninamide
(1R,2S)-2-amino-1-{[(3-methoxybenzyl)amino]methyl}-3-
phenylpropyl (2R)-2-[(4-ethoxy-4-oxobutyl)amino]-5-oxo-5-
piperidin-1-ylpentanoate
N,N-dimethyl-β-alanyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-
ethylbenzyl)-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-N 2 -
(methoxyacetyl)-D-alaninamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(2-butyl-1,3-dioxan-2-yl)-
N-(methoxycarbonyl)-D-alaninate
N 2 -acetyl-N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-methylbutyl)-D-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -cyclopropyl-N 2 -(cyclopropylcarbonyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 2 -acetyl-N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N-phenylglycyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N-acetyl-β-alanyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -(chloroacetyl)-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(methoxyacetyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(3-methoxypropanoyl)-3-
[(1-propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -(2,2-dimethylpropanoyl)-N 1 -(3-ethylbenzyl)-
3-[(1-propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -isobutyryl-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 2 -acetyl-N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -(cyclopropylcarbonyl)-N 1 -(3-ethylbenzyl)-3-
[(1-propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -propionyl-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
5-oxo-D-prolyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide hydrochloride
5-oxo-L-prolyl-N 1 -[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -[3-(4-oxo-2-thioxo-1,3-
thiazolidin-3-yl)propanoyl]-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(1H-imidazol-4-ylacetyl)-
3-[(1-propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(phenylacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(3-phenylpropanoyl)-3-
[(1-propylbutyl)sulfonyl]alaninamide
N-(3-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-3-oxo-2-{[(1-
propylbutyl)sulfonyl]methyl}propyl)benzamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 2 -
(cyclopropylacetyl)-N 1 -(3-methoxybenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-N 2 -[(methylsulfonyl)acetyl]-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-N 2 -[(methylthio)acetyl]-3-[(1-
propylbutyl)sulfonyl]alaninamide
N-(methylsulfonyl)glycyl-N 1 -[(2R,3S)-3-amino-2-hydroxy-
4-phenylbutyl]-N 1 -(3-methoxybenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 2 -acetyl-N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-
N 1 -(3-methoxybenzyl)-3-(phenylsulfonyl)alaninamide
2-[[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl](3-ethylbenzyl)amino]-1-
[(butylsulfonyl)methyl]-2-oxoethyl acetate
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-S-butyl-N 1 -(3-ethylbenzyl)-D-cysteinamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfinyl)-N 1 -(3-ethylbenzyl)-D-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-D-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethylbenzyl)-L-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-methylbutyl)-D-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -[1-(3-ethylphenyl)cyclopropyl]-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-L-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -cyclopropyl-3-[(1-propylbutyl)sulfonyl]-D-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-methylbutyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(phenoxyacetyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 2 -{[(5-chloro-2-thienyl)thio]peroxy}-N 1 -(3-
ethylbenzyl)-3-[(1-propylbutyl)sulfonyl]alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N 1 -(3-ethylbenzyl)-N 2 -(phenylsulfonyl)-3-[(1-
propylbutyl)sulfonyl]alaninamide
N 2 -[(benzylamino)carbonyl]-N 1 -[(2R,3S)-4-(3,5-
difluorophenyl)-2-hydroxy-3-(methylamino)butyl]-N 1 -(3-
ethylbenzyl)-3-[(1-propylbutyl)sulfonyl]alaninamide
4-[[(2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-
(methylamino)butyl](3-ethylbenzyl)amino]-4-oxo-3-{[(1-
propylbutyl)sulfonyl]methyl}butanoic acid
4-[[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](3-
methoxybenzyl)amino]-3-{[(3-methylbutyl)sulfonyl]methyl}-4-
oxobutanoic acid
methyl 4-[[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](3-
methoxybenzyl)amino]-3-{[(3-methylbutyl)sulfonyl]methyl}-4-
oxobutanoate
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-2-{[(3-
methylbutyl)sulfonyl]methyl}succinamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-N 4 -methyl-2-{[(3-
methylbutyl)sulfonyl]methyl}succinamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-N 4 ,N 4 -dimethyl-2-{[(3-
methylbutyl)sulfonyl]methyl}succinamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-N-
(3-ethylbenzyl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-N-
(3-ethylbenzyl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanamide
(1R,2S)-2-amino-3-(3,5-difluorophenyl)-1-{[(3-
ethylbenzyl)amino]methyl}propyl 3-(4,4-dimethyl-2,5-
dioxoimidazolidin-1-yl)-2-{[(1-
propylbutyl)sulfonyl]methyl}propanoate
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-3-
(ethylsulfonyl)-2-{[(isobutylsulfonyl)amino]methyl}-N-(3-
methoxybenzyl)propanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-3-
(ethylthio)-2-{[(isobutylsulfonyl)amino]methyl}-N-(3-
methoxybenzyl)propanamide
(2S)—N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-2-{[(3-methylbutyl)sulfonyl]amino}-4-
(methylsulfonyl)butanamide
N 1 -[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N 1 -(3-
methoxybenzyl)-N 2 -[(3-methylbutyl)sulfonyl]-L-methioninamide
S-(3-[[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](3-
methoxybenzyl)amino]-2-{[(3-methylbutyl)sulfonyl]methyl}-3-
oxopropyl) ethanethioate
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-3-[(1-propylbutyl)sulfonyl]propanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-3-[(3-methylbutyl)sulfonyl]propanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-3-[(3-methoxyphenyl)sulfonyl]propanamide
N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-hydroxy-4-
(phenylsulfonyl)butanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-4-[(3-methylbutyl)sulfonyl]butanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-4-[(3-methylbutyl)sulfonyl]-2-
phenoxybutanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-2-(3-methoxyphenoxy)-4-[(3-
methylbutyl)sulfonyl]butanamide
3-{1-{[[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl](3-
methoxybenzyl)amino]carbonyl}-3-[(3-
methylbutyl)sulfonyl]propoxy}benzoic acid
methyl 3-{1-{[[(2R,3S)-3-amino-2-hydroxy-4-
phenylbutyl](3-methoxybenzyl)amino]carbonyl}-3-[(3-
methylbutyl)sulfonyl]propoxy}benzoate
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-4-(phenylsulfonyl)butanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-hydroxy-
N-(3-methoxybenzyl)-4-(phenylthio)butanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-methoxy-
N-(3-methoxybenzyl)-4-(phenylsulfonyl)butanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-methoxy-
N-(3-methoxybenzyl)-4-(phenylthio)butanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(3-
methoxybenzyl)-4-(phenylsulfonyl)-2-propoxybutanamide
N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-2-
(benzyloxy)-N-(3-methoxybenzyl)-4-(phenylsulfonyl)butanamide
(2S)-2-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-
phenylbutyl]-N-(3-methoxybenzyl)-5-oxo-5-piperidin-1-
ylpentanamide
(2R)-2-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-
phenylbutyl]-N-(3-methoxybenzyl)-5-oxo-5-piperidin-1-
ylpentanamide
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-3-oxoheptyl)carbamate
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-3,3-difluoroheptyl)carbamate
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-3-fluoroheptyl)carbamate
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-4-oxooctyl)carbamate
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-4-hydroxyoctyl)carbamate
methyl [(1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-3-(2-butyl-1,3-dioxolan-2-
yl)propyl]carbamate
methyl [(1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-3-(2-butyl-1,3-dioxan-2-
yl)propyl]carbamate
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-4-fluorooctyl)carbamate
methyl ((1R)-1-{[[(2R,3S)-3-amino-4-(3,5-
difluorophenyl)-2-hydroxybutyl](3-
ethylbenzyl)amino]carbonyl}-4,4-difluorooctyl)carbamate
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-
{[(methylamino)carbonyl]amino}-4-oxooctanamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-butyl-N 1 -(3-ethylbenzyl)-N 2 -
[(methylamino)carbonyl]-D-homoserinamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(2-butyl-1,3-dioxolan-2-yl)-N 1 -(3-
ethylbenzyl)-N 2 -[(methylamino)carbonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(2-butyl-1,3-dioxan-2-yl)-N 1 -(3-
ethylbenzyl)-N 2 -[(methylamino)carbonyl]-D-alaninamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4,4-difluoro-2-
{[(methylamino)carbonyl]amino}octanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-4-fluoro-2-
{[(methylamino)carbonyl]amino}octanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-2-
{[(methylamino)carbonyl]amino}-5-oxononanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-hydroxy-2-
{[(methylamino)carbonyl]amino}nonanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(2-butyl-1,3-dioxolan-2-yl)-N-(3-
ethylbenzyl)-2-{[(methylamino)carbonyl]amino}butanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-4-(2-butyl-1,3-dioxan-2-yl)-N-(3-ethylbenzyl)-
2-{[(methylamino)carbonyl]amino}butanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5-fluoro-2-
{[(methylamino)carbonyl]amino}nonanamide
(2R)—N-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-N-(3-ethylbenzyl)-5,5-difluoro-2-
{[(methylamino)carbonyl]amino}nonanamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -(3-ethynylbenzyl)-N 2 -
[(methylamino)carbonyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 2 -[(methylamino)carbonyl]-
N 1 -[3-(trifluoromethyl)benzyl]-D-alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -[1-(3-
ethylphenyl)cyclopropyl]-N 2 -[(methylamino)carbonyl]-D-
alaninamide
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 1 -[1-(3-
ethynylphenyl)cyclopropyl]-N 2 -[(methylamino)carbonyl]-D-
alaninamide, and
N 1 -[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-
hydroxybutyl]-3-(butylsulfonyl)-N 2 -[(methylamino)carbonyl]-
N 1 -{1-[3-(trifluoromethyl)phenyl]cyclopropyl}-D-alaninamide.
12 . A method of generating a compound of formula (Y):
comprising exposing a compound according to claim 1 to aqueous media, wherein R 1 , R 2 , R 3 , R N and R C are as defined in claim 1 .
13 . The method of claim 12 wherein the generation of the compound of formula (Y) occurs in vitro.
14 . The method of claim 12 wherein the generation of the compound of formula (Y) occurs in vivo.
15 . The method of claim 12 wherein the aqueous media has a pH of about 2 to about 10.
16 . The method of claim 3 wherein the aqueous media has a pH of about 3 to about 7.
17 . A method for the treatment or prevention of Alzheimer's disease, mild cognitive impairment Down's syndrome, Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-Type, cerebral amyloid angiopathy, other degenerative dementias, dementias of mixed vascular and degenerative origin, dementia associated with Parkinson's disease, dementia associated with progressive supranuclear palsy, dementia associated with cortical basal degeneration, diffuse Lewy body type of Alzheimer's disease comprising administering a therapeutically effective amount of a compound or salt according to claim 1 , to a patient in need thereof.
18 . A method for the treatment or prevention of Alzheimer's disease, mild cognitive impairment Down's syndrome, Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-Type, cerebral amyloid angiopathy, other degenerative dementias, dementias of mixed vascular and degenerative origin, dementia associated with Parkinson's disease, dementia associated with progressive supranuclear palsy, dementia associated with cortical basal degeneration, diffuse Lewy body type of Alzheimer's disease comprising administration of a therapeutically effective amount of a compound or salt according to claim 1 , to a patient in need thereof.
19 . The use of a compound or salt according to claim 1 for the manufacture of a medicament.
20 . The use of a compound or salt according to claim 1 for the manufacture of a medicament for use in the treatment or prevention of Alzheimer's disease, mild cognitive impairment Down's syndrome, Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-Type, cerebral amyloid angiopathy, other degenerative dementias, dementias of mixed vascular and degenerative origin, dementia associated with Parkinson's disease, dementia associated with progressive supranuclear palsy, dementia associated with cortical basal degeneration, or diffuse Lewy body type of Alzheimer's disease.
21 . A compound according to claim 1 selected from the group consisting of:
22 . A pharmaceutical composition comprising a compound according to claims 1 in combination with a physiologically acceptable carrier or excipient.Join the waitlist — get patent alerts
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