Methods and compositions for promoting organ development

Abstract

Compositions and methods are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or foetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (CSF-1), precursor, variant, analogue, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (CSF-1), precursor, variant, analogue, derivative thereof, or combinations thereof.

1 . A composition for the treatment of complications arising from or related to low birth weight in a mammal comprising:
 a low birth weight complications-reducing or-limiting amount of at least one colony stimulating factor-1 protein (CSF-1), or at least one precursor, variant, analogue or derivative thereof, or a therapeutically effective amount of at least one nucleic acid molecule encoding a low birth weight complications-reducing or-limiting amount of said at least one colony stimulating factor-1 protein (CSF-1), or at least one precursor, variant, analogue or derivative thereof; and   a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         2 . A composition for promoting organ development in a mammal comprising a mammal organ development-enhancing amount of colony stimulating factor-1 protein (CSF-1), or a precursor, variant, analogue or derivative thereof, or a therapeutically effective amount of a nucleic acid molecule encoding a premature infant or foetus organ development-enhancing amount of said colony stimulating factor-1 protein (CSF-1), or a precursor, variant, analogue or derivative thereof; and
 a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         3 . A composition for promoting lung growth and/or enhancing lung development and/or maturation in a mammal comprising a mammal lung growth promoting and/or lung development and/or maturation-enhancing amount of colony stimulating factor-1 protein (CSF-1), or a precursor, variant, analogue or derivative therefore, or a therapeutically effective amount of a nucleic acid molecule encoding a mammal lung growth promoting and/or lung development and/or maturation-enhancing amount of said colony stimulating factor-1 protein (CSF-1), or a precursor, variant, analogue or derivative thereof; and
 a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         4 . A composition for promoting growth, maturation and/or enhancing kidney development in a mammal comprising a mammal kidney growth maturation and/or development-enhancing amount of at least one colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof, or a therapeutically effective amount of at least one nucleic acid molecule encoding a mammal kidney growth maturation and/or development-enhancing amount of at least one said colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof; and
 a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         5 . A composition for promoting bone growth and/or enhancing bone development and/or maturation in a mammal comprising a mammal bone growth promoting and/or bone development and/or maturation-enhancing amount of at least one colony stimulating factor-1 protein (CSF-1), and/or a precursor, variant, analogue, derivative thereof or combination thereof, or a therapeutically effective amount of at least one nucleic acid molecule encoding a mammal bone growth promoting and/or bone development and/or maturation-enhancing amount of said at least one colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof; and
 a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         6 . The composition according to  claim 1 , wherein said mammal comprises a premature infant, a low birth weight infant or a foetus. 
     
     
         7 . A method of treating complications arising from or related to low birth weight in mammals comprising administering to said mammals:
 at least one colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof, or at least one nucleic acid molecule encoding said at least one colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof.   
     
     
         8 . A method of promoting organ development and/or maturation in mammals comprising administering to the mammal;
 colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof or a nucleic acid molecule encoding said colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof.   
     
     
         9 . A method of promoting lung growth and/or enhancing lung development and/or maturation in mammals, comprising administering to said mammals:
 colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof, or a nucleic acid molecule encoding said colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof.   
     
     
         10 . A method of promoting growth, maturation and/or enhancing kidney development mammals comprising administering to said mammals:
 colony stimulating factor-1 protein(CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof, or a nucleic acid molecule encoding said colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof.   
     
     
         11 . A method of promoting bone growth and/or enhancing bone development and/or maturation in mammals comprising administering to said mammals:
 colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof or a nucleic acid molecule encoding said colony stimulating factor-1 (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination.   
     
     
         12 . The method of according to  claim 7  wherein said mammal comprises a premature infant, a low birth weight infant or a foetus. 
     
     
         13 . A method of promoting lung growth and/or enhancing lung development and/or maturation in mammals, comprising administering to said mammals:
 colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof, or a nucleic acid molecule encoding said colony stimulating factor-1 protein (CSF-1), and/or at least one precursor, variant, analogue, derivative thereof or combination thereof; and   at least one surfactant.   
     
     
         14 . A composition for promoting lung growth and/or enhancing lung development and/or maturation in a premature infant, in a low birth weight infant or in a foetus comprising:
 a premature infant, low birth weight infant or foetus lung growth promoting and/or lung development and/or maturation-enhancing amount of colony stimulating factor-1 protein (CSF-1); and   a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         15 . A composition for promoting growth, maturation and/or enhancing kidney development in a premature infant, in a low birth weight infant or in a foetus comprising:
 a premature infant, low birth weight infant or foetus kidney growth maturation and/or development-enhancing amount of colony stimulating factor-1 protein (CSF-1); and   a pharmaceutically acceptable excipient, vehicle or diluent.   
     
     
         16 . A method of promoting lung growth and/or enhancing lung development and/or maturation in a premature infant, in a low birth weight infant or in a foetus, comprising administering to said premature infant, low birth weight infant or foetus:
 colony stimulating factor-1 protein (CSF-1).   
     
     
         17 . A method of promoting growth, maturation and/or enhancing kidney development in a premature infant, in a low birth weight infant or in a foetus comprising administering to said premature infant, low birth weight infant or foetus:
 colony stimulating factor-1 protein (CSF-1).