High viscosity liquid controlled delivery system and medical or surgical device

Abstract

The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.

1 - 45 . (canceled) 
     
     
         46 . A composition for the controlled release delivery of a substance, said composition comprising: sucrose acetate isobutyrate (SAIB); a solvent in which the SAIB is soluble; and a substance to be delivered. 
     
     
         47 . The composition of  claim 46 , wherein the solvent is selected from the group consisting of ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, benzyl alcohol, triacetin, N-methylpyrrolidone, propylene carbonate or glycofurol. 
     
     
         48 . The composition of  claim 46 , wherein the substance to be delivered is a biologically active substance. 
     
     
         49 . The composition of  claim 48 , wherein the biologically active substance is a drug, peptide, protein, carbohydrate, nucleoprotein, mucoprotein, lipoprotein, synthetic polypeptide or protein, or a small molecule linked to a protein, glycoprotein, steroid, nucleic acid or a fragment thereof, nucleotide, nucleoside, oligonucleotide, gene, lipid, hormone or vitamin. 
     
     
         50 . The composition of  claim 49 , wherein the drug is an immunosuppressant, antioxidant, anesthetic, chemotherapeutic agent, steroid, hormone, antibiotic, antiviral, antifungal, antiproliferative, antihistamine, anticoagulant, antiphotoaging agent, melanotropic peptide, nonsteroidal or steroidal anti-inflammatory compound, antipsychotic or a radiation absorber. 
     
     
         51 . The composition of  claim 46 , wherein said composition is suitable for administration by injection. 
     
     
         52 . The composition of  claim 46 , wherein said composition is suitable for forming a medical or surgical implant.