Antibiotic compostions and methods for using same

Abstract

Compositions including a quinolone component in an amount effective as an antibiotic when the composition is placed in a mammalian eye, and a carrier component in an amount effective to act as a carrier for the quinolone component are provided. The present compositions are substantially free of other components effective as preservatives. Preferably the quinolone component has fungistatic activity. In one very useful embodiment, the compositions include a NSAID component in an amount effective to reduce inflammation or pain when the composition is placed in a mammalian eye. Methods of using the present compositions, for example, to resolve microbial infections and/or to reduce inflammation and/or pain in a mammalian eye are included within the scope of the present invention.

1 - 35 . (canceled) 
     
     
         36 . An ophthalmically acceptable composition comprising from about 0.15% to about 1.1% of a quinolone antibiotic present in a therapeutically effective amount, wherein said composition contains substantially no additional components which are effective as preservatives, is self-preserved, and is suitable for topical application to the eye. 
     
     
         37 . The composition of  claim 36  wherein said quinolone is a halogenated quinolone antibiotic. 
     
     
         38 . The composition of  claim 36  wherein the quinolone is a fluorinated quinolone antibiotic. 
     
     
         39 . The composition of  claim 36  in a liquid form. 
     
     
         40 . The composition of  claim 36  in a gel form. 
     
     
         41 . The composition of  claim 36  in a solid form. 
     
     
         42 . The composition of  claim 36  which contains a water soluble polymer. 
     
     
         43 . The composition of  claim 42  wherein said water soluble polymer is a cellulose derivative. 
     
     
         44 . The composition of  claim 36 , wherein said composition contains sufficient preservative efficacy to pass the U.S. Preservative Efficacy Test. 
     
     
         45 . A method of treating an ocular infection without substantial irritation caused by added preservatives comprising administering to a mammalian eye an ophthalmically acceptable solution comprising from about 0.15% to about 1.1% of a quinolone antibiotic present in a therapeutically effective amount, wherein said composition contains substantially no additional components which are effective as preservatives, and is self-preserved. 
     
     
         46 . The method of  claim 45  wherein the composition comprises a water soluble polymer. 
     
     
         47 . The method of  claim 46  wherein the water soluble polymer is a cellulose derivative. 
     
     
         48 . The method of  claim 45  wherein the quinolone antibiotic is a halogenated quinolone. 
     
     
         49 . The method of  claim 48  wherein the quinolone antibiotic is a fluorinated quinolone. 
     
     
         50 . The method of  claim 45  wherein said composition contains sufficient preservative efficacy to pass the U.S. Preservative Efficacy Test. 
     
     
         51 . The method of  claim 45  wherein said composition is administered topically.