US2008139808A1PendingUtilityA1

Crystal forms of lamotrigine and processes for their preparations

63
Assignee: TEVA PHARMAPriority: Feb 27, 2001Filed: Jan 30, 2008Published: Jun 12, 2008
Est. expiryFeb 27, 2021(expired)· nominal 20-yr term from priority
Inventors:Nissim GartiYana BerkovichBen-Zion DolitzkyJudith AronhimeClaude SingerAnita LiebermannNeomi Gershon
C07D 253/075A61P 25/08
63
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Claims

Abstract

The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.

Claims

exact text as granted — not AI-modified
1 .- 116 . (canceled) 
     
     
         117 . A method for preparing anhydrous crystalline 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, comprising heating at least one crystalline 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine solvate of a solvent selected from the group consisting of dimethylformamide, dimethylamine, methanol, ethanol, isopropyl alcohol, tetrahydrofuran and acetone. 
     
     
         118 . The method of  claim 117 , wherein the solvent is dimethylformamide. 
     
     
         119 . The method of  claim 117 , wherein the solvent is dimethylamine. 
     
     
         120 . The method of  claim 117 , wherein the solvent is methanol. 
     
     
         121 . The method of  claim 117 , wherein the solvent is ethanol. 
     
     
         122 . The method of  claim 117 , wherein the solvent is isopropyl alcohol. 
     
     
         123 . The method of  claim 117 , wherein the solvent is tetrahydrofuran. 
     
     
         124 . The method of  claim 117 , wherein the solvent is acetone.

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