Use of Flumazenil in the Production of a Drug for the Treatment of Alcohol Dependency

Abstract

The invention relates to the use of flumazenil in developing a drug used for the sequential administration of small quantities of flumazenil at short intervals, until a therapeutically effective quantity is administered to treat alcohol dependence.

1 . Use of flumazenil to produce a drug for sequential administration, at time intervals between 1 and 15 minutes, of quantities of flumazenil between 0.1 and 0.3 mg, until a therapeutically effective quantity of flumazenil to treat alcohol dependency has been administered. 
     
     
         2 . Use according to  claim 1 , wherein said therapeutically effective quantity of flumazenil to treat alcohol dependency is between 1.5 and 2.5 mg/day of flumazenil. 
     
     
         3 . Use according to  claim 1 , wherein said drug includes some pharmaceutical compositions that contain 0.2 mg of flumazenil. 
     
     
         4 . Use according to  claim 1 , wherein the sequential administration of said drug, made up of pharmaceutical compositions, is carried out at intervals of 3 minutes. 
     
     
         5 . Use according to  claim 1 , wherein said therapeutically effective quantity to treat alcohol dependency is 2 mg/day. 
     
     
         6 . Use according to  claim 1 , wherein said flumazenil-based drug is administered orally or parenterally. 
     
     
         7 . Use according to  claim 6 , wherein said flumazenil-based drug is carried out [sic] intravenously. 
     
     
         8 . Use of flumazenil to produce a drug for administration, sequentially, of 0.2 mg of flumazenil at time intervals of 3 minutes, up to a quantity of 2 mg/day, to treat alcohol dependency. 
     
     
         9 . Method for the treatment of alcohol dependency that includes the administration to a patient in need of said treatment of a therapeutically effective quantity of flumazenil, broken down into quantities of flumazenil between 0.2 and 0.3 mg and intended for sequential administration, at time intervals between 1 and 15 minutes, until said therapeutically effective quantity of flumazenil to treat alcohol dependency has been reached. 
     
     
         10 . Method according to  claim 9 , wherein said therapeutically effective quantity of flumazenil to treat alcohol dependency is between 1.5 and 2.5 mg/day of flumazenil. 
     
     
         11 . Method according to  claim 9 , wherein the quantity of flumazenil that is administered in each sequential application is 0.2 mg. 
     
     
         12 . Method according to  claim 9 , wherein the sequential administration of flumazenil takes place at intervals of 3 minutes. 
     
     
         13 . Method according to  claim 9 , wherein said therapeutically effective quantity to treat alcohol dependency is 2 mg/day. 
     
     
         14 . Method according to  claim 9 , wherein the administration of the flumazenil takes place orally or parenterally. 
     
     
         15 . Method according to  claim 14 , wherein the administration of flumazenil takes place intravenously. 
     
     
         16 . Method for the treatment of alcohol dependency that includes the administration, to a patient in need of said treatment, of a therapeutically effective quantity of flumazenil of 2 mg/day of flumazenil, broken down into quantities of 0.2 mg of flumazenil and intended for sequential administration, at intervals of 3 minutes, until said therapeutically effective quantity of flumazenil to treat alcohol dependency has been reached.