Infant Formula

Abstract

The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (Np x N); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.

1 - 14 . (canceled) 
     
     
         15 . A nutritional composition comprising
 a. a protein,   b. a fat,   c. a carbohydrate;   d. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates; and   e. a non-proteinaceous, negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20,000 Dalton.   
     
     
         16 . The nutritional composition according to  claim 15 , wherein the glycan or glycoconjugate component has a molecular weight between 1,000 and 10,000 Dalton. 
     
     
         17 . The nutritional composition according to  claim 15 , comprising 5 to 15 energy % protein; 30 to 60 energy % fat; and 25 to 65 energy % carbohydrate. 
     
     
         18 . The nutritional composition according to  claim 15 , comprising, per 100 gram dry weight of the composition, between 5 and 100 mg nucleotides; between 5 and 100 mg nucleosides; or both. 
     
     
         19 . The nutritional composition according to  claim 15 , wherein the nucleotide component is ribose. 
     
     
         20 . The nutritional composition according to  claim 18 , wherein the nucleotide component is ribose. 
     
     
         21 . The nutritional composition according to  claim 15  further comprising between 150 and 1000 mg calcium; 2 to 100 mg zinc; or both. 
     
     
         22 . The nutritional composition according to  claim 15  wherein the negatively charged glycan or glycoconjugate component comprises acidic oligosaccharides, acid gangliosides, or both. 
     
     
         23 . The nutritional composition according to  claim 22 , wherein the negatively charged glycan or glycoconjugate component is a polygalacturonic acid with a DP between 2 and 100. 
     
     
         24 . The nutritional composition according to  claim 23 , wherein the polygalacturonic acid is pectin hydrolysate. 
     
     
         25 . The nutritional composition according to claim  8 , wherein the negatively charged glycan or glycoconjugate component is a ganglioside. 
     
     
         26 . A method for providing nutrition to an infant, said method comprising administering to the infant a nutritional composition comprising
 a. a protein,   b. a fat,   c. a carbohydrate;   d. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates; and   e. a non-proteinaceous, negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20,000 Dalton.   
     
     
         27 . A method of treatment and/or prevention of an inflammatory disease, diarrhea, eczema and/or atopic dermatitis, comprising administering to the mammal a nutritional composition comprising
 a. a protein,   b. a fat,   c. a carbohydrate;   d. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates; and   e. a non-proteinaceous, negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20,000 Dalton.   
     
     
         28 . The method according to  claim 27 , wherein the inflammatory disease is allergy. 
     
     
         29 . The method according to  claim 28 , wherein the mammal is a human. 
     
     
         30 . The method according to  claim 29 , wherein the human is an infant.