Pharmaceutical Composition Comprising Factor VII Polypeptides and TAFI Polypeptides

Abstract

The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and TAFI or a TAFI-related polypeptide, and the use thereof for treating bleeding episodes.

1 . A method for treating bleeding episodes in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation of factor VII or a factor VII-related polypeptide and a second amount of a preparation of TAFI or a TAFI-related polypeptide, wherein the first and second amount together are effective to treat bleedings.  
     
     
         2 . A method for reducing clotting time in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation of factor VII or a factor VII-related polypeptide and a second amount of a preparation of TAFI or a TAFI-related polypeptide wherein the first and second amount together are effective to reduce clotting time.  
     
     
         3 . A method to enhance haemostasis in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation of factor VII or a factor VII-related polypeptide and a second amount of a preparation of TAFI or a TAFI-related polypeptide wherein the first and second amount together are effective to enhance haemostasis.  
     
     
         4 . A method for prolonging the clot lysis time in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation of factor VII or a factor VII-related polypeptide and a second amount of a preparation of TAFI or a TAFI-related polypeptide wherein the first and second amount together are effective to prolong the clot lysis time.  
     
     
         5 . A method for increasing clot strength in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation of factor VII or a factor VII-related polypeptide and a second amount of a preparation of TAFI or a TAFI-related polypeptide wherein the first and second amount together are effective to increase clot strength.