US2008051299A1PendingUtilityA1

DNA-protein fusions and uses thereof

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Assignee: LOHSE PETERPriority: Dec 2, 1998Filed: Mar 22, 2007Published: Feb 28, 2008
Est. expiryDec 2, 2018(expired)· nominal 20-yr term from priority
Inventors:Peter LohseMarkus Kurz
C07H 19/20C40B 30/04C40B 40/00C07K 14/00C07H 21/00C12N 15/1062C12N 15/1075C40B 40/10C40B 50/14C40B 40/08C07B 2200/11C12N 15/1096C12N 15/10
60
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Claims

Abstract

Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.

Claims

exact text as granted — not AI-modified
1 - 15 . (canceled)  
     
     
         16 . A molecule comprising a DNA covalently bonded to a protein through a peptide acceptor.  
     
     
         17 . The molecule of  claim 16 , wherein said peptide acceptor is puromycin.  
     
     
         18 . The molecule of  claim 16 , wherein said protein comprises at least 10 amino acids.  
     
     
         19 . A molecule comprising a DNA covalently bonded to a protein, said protein comprising at least 10 amino acids.  
     
     
         20 . The molecule of  claim 16  or  19 , wherein said protein comprises at least 30 amino acids.  
     
     
         21 . The molecule of  claim 20 , wherein said protein comprises at least 100 amino acids.  
     
     
         22 . The molecule of  claim 16  or  19 , wherein said protein is encoded by said DNA.  
     
     
         23 . The molecule of  claim 16  or  19 , wherein said protein is entirely encoded by said DNA.  
     
     
         24 . The molecule of  claim 16  or  19 , wherein said molecule further comprises a ribonucleic acid covalently bonded to said DNA.  
     
     
         25 . The molecule of  claim 24 , wherein said protein is encoded by said ribonucleic acid.  
     
     
         26 . The molecule of  claim 16  or  19 , wherein said DNA is double stranded.  
     
     
         27 . A population of at least 10 5  DNA-protein fusions, each fusion comprising a DNA covalently bonded to a protein.  
     
     
         28 . The population of  claim 27 , wherein said population comprises at least 10 14  fusions.  
     
     
         29 . The population of  claim 27 , wherein said protein comprises at least 10 amino acids.  
     
     
         30 . The population of  claim 29 , wherein said protein comprises at least 30 amino acids.  
     
     
         31 . The population of  claim 30 , wherein said protein comprises at least 100 amino acids.  
     
     
         32 . The population of  claim 27 , wherein said protein is encoded by said covalently bonded DNA.  
     
     
         33 . The population of  claim 27 , wherein said protein is entirely encoded by said covalently bonded DNA.  
     
     
         34 . The population of  claim 27 , wherein said fusions further comprise a ribonucleic acid covalently bonded to said DNA.  
     
     
         35 . The population of  claim 34 , wherein said protein is encoded by said ribonucleic acid.  
     
     
         36 . The population of  claim 27 , wherein said DNA is covalently bonded to said protein through a peptide acceptor.  
     
     
         37 . The population of  claim 36 , wherein said peptide acceptor is puromycin.  
     
     
         38 . The population of  claim 27 , wherein said DNA is double stranded.  
     
     
         39 . A solid support comprising an array of immobilized molecules, each comprising a DNA covalently bonded to a protein.  
     
     
         40 . The solid support of  claim 39 , wherein said protein is encoded by said DNA.  
     
     
         41 . The solid support of  claim 39 , wherein said solid support is a microchip.

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