Fibroblast Growth Factor Receptor-Like Molecules and Uses Thereof

Abstract

The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGFR-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with FGFR-L, polypeptides.

1 . An isolated nucleic acid molecule comprising a nucleotide sequence: 
 (a) as set forth in SEQ ID NO: 4;    (b) encoding the polypeptide as set forth in SEQ ID NO: 5;    (c) that is complementary to the nucleotide sequence of either (a) or (b).    
   
   
       2 . A vector comprising the nucleic acid molecule of  claim 1 .  
   
   
       3 . A host cell comprising the vector of  claim 2 .  
   
   
       4 . The host cell of  claim 3  that is a eukaryotic cell.  
   
   
       5 . The host cell of  claim 3  that is a prokaryotic cell.  
   
   
       6 . An isolated nucleic acid molecule comprising a nucleotide sequence: 
 (a) as set forth in SEQ ID NO: 23;    (b) encoding the polypeptide as set forth in SEQ ID NO: 8;    (c) that is complementary to the nucleotide sequence of either (a) or (b).    
   
   
       7 . A vector comprising the nucleic acid molecule of  claim 6 .  
   
   
       8 . A host cell comprising the vector of  claim 7 .  
   
   
       9 . The host cell of  claim 8  that is a eukaryotic cell.  
   
   
       10 . The host cell of  claim 8  that is a prokaryotic cell.  
   
   
       11 . A process of producing a Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptide encoded by the nucleic acid molecule of claims  1  or  7  comprising culturing a host cell comprising the nucleic acid molecule of any of claims  1 (a),  1 (b)  6 (a), or  6 (b) under suitable conditions to express the polypeptide, and optionally isolating the polypeptide from the culture.  
   
   
       12 . The process of  claim 11 , wherein the nucleic acid molecule comprises promoter DNA other than the promoter DNA for the native FGFR-L polypeptide operatively linked to the DNA encoding the FGFR-L polypeptide.