Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein

Abstract

An interstitial fluid (ISF) extraction device includes a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom and at least three concentrically-arranged pressure rings, each adapted for applying pressure to the user's skin layer in the vicinity of the target site while the penetration member is residing in the user's skin layer. In addition, the ISF extraction device is configured such that (i) the pressure rings apply pressure in an oscillating manner with asymmetric deployment and retraction cycles and (ii) only one of the at least three concentrically-arranged pressure rings is deployed at a time, thereby mitigating an ISF glucose lag of the ISF sample extracted by the penetration member.

1 - 23 . (canceled)  
     
     
         24 . An interstitial fluid (ISF) extraction device for mitigating ISF glucose lag, the ISF extraction device comprising: 
 a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom; and    at least one pressure ring adapted for applying pressure to the user's skin layer in the vicinity of the target site while the penetration member is residing in the user's skin layer,    wherein the pressure ring applies the pressure in an oscillating manner wherein the pressure is applied for a time period in the range of 30 seconds to ten minutes, the pressure is subsequently removed for a time period in the range of five minutes to ten minutes and then the pressure is re-applied for a period in the range 30 seconds to ten minutes.    
     
     
         25 . The ISF extraction device of  claim 24  wherein the pressure ring applies the pressure in an oscillating manner wherein the pressure is applied for one minute, the pressure is subsequently removed for ten minutes and then the pressure is re-applied for one minute.  
     
     
         26 . The ISF extraction device of  claim 24  further comprising: at least one first biasing member configured for moving the pressure ring between a deployed state and a retracted state; and 
 a second biasing member configured for launching the penetration member.    
     
     
         27 . The ISF extraction device of  claim 24 , wherein the penetration member is configured to reside in the user's skin layer for a period of at least 1 hour.  
     
     
         28 . The ISF extraction device of  claim 24 , wherein the at least one pressure ring is a plurality of pressure rings.  
     
     
         29 . The ISF extraction device of  claim 28 , wherein the pressure rings are arranged concentrically.  
     
     
         30 . The ISF extraction device of  claim 24 , wherein the pressure ring and the first biasing element are configured to apply a pressure in the range of 0.1 to 150 pounds per square inch to a user's skin layer.  
     
     
         31 . A method for extracting interstitial fluid (ISF) and mitigating ISF glucose lag, the method comprising: 
 providing an ISF fluid extraction device that includes a penetration member and at least one pressure ring;    contacting the pressure ring with a user's skin layer;    penetrating the user's skin layer with the penetration member; and    extracting an ISF sample from the user's skin layer with the penetration member while applying pressure to the user's skin layer in an oscillating manner using the pressure ring wherein the pressure is applied for a time period in the range of 30 seconds to ten minutes, the pressure is subsequently removed for a time period in the range of five minutes to ten minutes and then the pressure is re-applied for a period in the range 30 seconds to ten minutes.    
     
     
         32 . The method of  claim 31 , wherein the providing step includes providing an ISF fluid extraction device that includes a plurality of pressure rings.  
     
     
         33 . The method of  claim 32 , wherein the providing step includes providing an ISF fluid extraction device with three concentrically arranged pressure rings.  
     
     
         34 . The method of  claim 31 , wherein the extracting step includes applying pressure in an asymmetric oscillating manner.