US2008020462A1PendingUtilityA1

Atm kinase compositions and methods

59
Assignee: ST JUDE CHILDRENS RES HOSPITALPriority: Nov 27, 2002Filed: Aug 17, 2007Published: Jan 24, 2008
Est. expiryNov 27, 2022(expired)· nominal 20-yr term from priority
Inventors:Michael KastanChristopher Bakkenist
Y02A50/30C07K 16/40A61K 31/675G01N 2800/52G01N 33/6812C12N 5/0602C12Q 1/485G01N 33/6842C12N 2501/06A61K 31/4706G01N 33/6893C12N 2501/999
59
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Claims

Abstract

The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of identifying agents which modulate the activation and activity of ATM kinase are also provided.

Claims

exact text as granted — not AI-modified
1 - 4 . (canceled)  
   
   
       5 . A method of enhancing a cellular response to DNA damage comprising administering an effective amount of an agent which agonizes the activation of Ataxia-Telangiectasia Mutated kinase so that a cellular response to DNA damage is enhanced.  
   
   
       6 . The method of  claim 5 , wherein the agent is selected from the group comprising chloroquine or Trichostatin A.  
   
   
       7 . The method of  claim 5 , wherein the agent is radioprotectant.  
   
   
       8 . The method of  claim 5 , wherein the agent is cancer chemopreventive.  
   
   
       9 . The method of  claim 5 , wherein the agent is anti-aging.  
   
   
       10 . The method of  claim 5 , wherein the cellular response is via p53 activation.  
   
   
       11 . (canceled)

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