US2008014150A1PendingUtilityA1
Compositions and method for treating precancerous virus infection and prevention of cancer
Est. expiryJul 9, 2024(expired)· nominal 20-yr term from priority
Inventors:Robert Sabin
A61K 9/146A61K 41/0038A61P 35/00A61K 33/34A61K 45/06A61P 31/12A61K 9/5161Y02A50/30
70
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Claims
Abstract
An anti-cancer composition having biocompatible materials, which can selectively exploit chemical variations between normal cells and cancer cells to inhibit or prevent the proliferation of cancerous cells and methods of use.
Claims
exact text as granted — not AI-modified1 - 107 . (canceled)
108 . A composition for use as a pharmaceutical for targeting at least one pre-cancerous affecting virus, for prevention of cancer comprising: a core essentially of biologically acceptable fixed copper compound, and a sheath that encapsulates the biologically acceptable fixed copper compound.
109 . The composition as in claim 108 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
110 . The composition of claim 108 , wherein the composition is used for therapeutic treatment of hepatitis B virus.
111 . The composition of claim 108 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis B viral infection.
112 . The composition of claim 108 , wherein the composition is used for therapeutic treatment of hepatitis C virus.
113 . The composition of claim 108 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis C viral infection.
114 . The composition as in claim 108 wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
115 . The composition as in claim 108 wherein said virus is Epstein-Barr Virus (EBV) and said cancer is Burkitt's lymphoma.
116 . The composition as in claim 108 wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.
117 . The composition of claim 108 , wherein the sheath is formed of a material selected from the group consisting essentially of lipids, polypeptides, oligopeptides, polynucleotides, proteins, liposomes and combinations thereof.
118 . The composition of claim 108 , wherein the sheath is formed of a material selected from the group consisting essentially of a glucose, a saccharide, a polysaccharide, a dextran, liposomes, derivatives and combinations thereof.
119 . The composition of claims 108 , wherein a liposome coat encapsulates the sheath.
120 . The composition of claim 108 , wherein a polysaccharide sheath encapsulates the composition.
121 . The composition of claim 108 , wherein the biologically acceptable fixed copper compound is selected from the group consisting of copper hydroxide, copper oxide, copper oxychloride, copper carbonate basic, copper sulfate, copper-iron hydroxide, copper-iron oxide, copper-iron oxyhydroxide, copper sulfate basic, cuprous oxide, cupric hydroxide-iron hydroxide, cupric citrate, cupric glycinate, cupric gluconate, cupric phosphate, cuprobam, cupric salicylite, indigo copper, cupro-cupric sulfate, cuprous sulfate, cuprous sulfate hemihydrite, brochantite, langite, malachite, azurite, cheesylite, cornetite, dihydyrite, libethenite, phosphorochalcite, pseudolibethenite, pseudo-malachite, tagilite, antlerite, covellite, marshite, cuprite, chalcocite, Rogojski's salt, brochantite, hydrocyanite, chalcanthtite, nantokite and dolerophane.
122 . A chemical composition for use in targeting at least one pre-cancerous affecting virus, for prevention of cancer comprising: a core essentially of a fixed copper-iron compound, and a sheath that encapsulates the core of the copper-iron compound.
123 . The composition as in claim 122 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
124 . The composition of claim 122 , wherein the composition is used for therapeutic treatment of hepatitis B virus.
125 . The composition of claim 122 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis B viral infection.
126 . The composition of claim 122 , wherein the composition is used for therapeutic treatment of hepatitis C virus.
127 . The composition of claim 122 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis C viral infection.
128 . The composition as in claim 122 , wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
129 . The composition as in claim 122 , wherein said virus is Epstein-Barr Virus (EBV) and said cancer is Burkitt's lymphoma.
130 . The composition as in claim 122 , wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.
131 . The composition of claim 122 , wherein the sheath is formed of a material selected from the group consisting essentially of a glucose, a saccharide, a polysaccharide, a dextran, liposomes, derivatives and combinations thereof.
132 . The composition of claim 122 , wherein the sheath is formed of a material selected from the group consisting essentially of lipids, polypeptides, oligopeptides, polynucleotides, proteins, and combinations thereof.
133 . The composition of claims 122 , wherein a liposome coat encapsulates the sheath.
134 . The composition of claim 122 , wherein the fixed copper-iron compound core is copper hydroxide-iron hydroxide.
135 . The composition of claim 122 , wherein said fixed copper-iron compound core is copper hydroxide-iron oxide.
136 . The composition of claim 122 , wherein said fixed copper-iron compound core is copper-iron oxyhydroxide.
137 . The composition of claim 122 , wherein the core particle is targeted with a targeting agent.
138 . The composition of claim 122 , wherein the core particle is targeted with a marker.
139 . The composition of claim 122 , wherein the core particle is targeted with magnetic particles.
140 . A chemical composition for targeting at least one pre-cancerous affecting virus, for prevention of cancer comprising: a compound of synergistic components of a fixed copper and iron to form a core particle.
141 . The composition as in claim 140 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
142 . The composition of claim 140 , wherein the composition is used for therapeutic treatment of hepatitis B virus.
143 . The composition of claim 140 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis B viral infection.
144 . The composition of claim 140 , wherein the composition is used for therapeutic treatment of hepatitis C virus.
145 . The composition of claim 140 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis C viral infection.
146 . The composition as in claim 140 wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
147 . The composition as in claim 140 wherein said virus is Epstein-Barr Virus (EBV) and said cancer is Burkitt's lymphoma.
148 . The composition as in claim 140 wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.
149 . The composition of claim 140 , wherein the copper of the core particle is selected from the group consisting of copper hydroxide, copper oxide, copper oxychloride, copper carbonate basic, copper sulfate, copper-iron hydroxide, copper-iron oxide, copper-iron oxyhydroxide, copper sulfate basic, cuprous oxide, cupric hydroxide-iron hydroxide, cupric citrate, cupric glycinate, cupric gluconate, cupric phosphate, cuprobam, cupric salicylite, indigo copper, cupro-cupric sulfate, cuprous sulfate, cuprous sulfate hemihydrite, brochantite, langite, malachite, azurite, cheesylite, cornetite, dihydyrite, libethenite, phosphorochalcite, pseudolibethenite, pseudo-malachite, tagilite, antlerite, covellite, marshite, cuprite, chalcocite, Rogojski's salt, brochantite, hydrocyanite, chalcanthtite, nantokite and dolerophane.
150 . The composition of claim 140 , wherein the iron of the core particle is iron hydroxide.
151 . The composition of claim 140 , wherein the iron of the core particle is iron oxide.
152 . The composition of claim 140 , wherein the iron of the core particle is an iron compound.
153 . The composition of claim 140 , wherein the core particle is encapsulated with a sheath.
154 . The composition of claim 140 , wherein the core particle is coated with liposomes.
155 . The composition of claim 140 , wherein the core particle is targeted with a targeting agent.
156 . The composition of claim 140 , wherein the core particle is targeted with a marker.
157 . The composition of claim 140 , wherein the core particle is targeted with magnetic particles.
158 . A composition for medicinal use in mammals comprising: a biologically acceptable, fixed copper compound core, and said fixed copper compound core being encapsulated, encoated, adsorbed, complexed or bound in at least one of a sheath, a shell, a polymeric shell, a cover, a casing, an encoating, a jacket or combination thereof, and a pharmaceutically acceptable carrier, said sheath, shell, polymeric shell, cover, casing, encoating, jacket or combination thereof being made of a material targeting at least one pre-cancerous affecting virus, and preventing immediate chemical interaction of the core with the surrounding cellular environment; said fixed copper compound core further comprising a material that remains in circulation of the mammals, wherein said targeting of said virus is used for prevention of cancer.
159 . The composition as in claim 158 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
160 . The composition of claim 158 , wherein the composition is used for therapeutic treatment of hepatitis B virus.
161 . The composition of claim 158 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis B viral infection.
162 . The composition of claim 158 , wherein the composition is used for therapeutic treatment of hepatitis C virus.
163 . The composition of claim 158 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis C viral infection.
164 . The composition of claim 158 , wherein the composition is used for therapeutic treatment of pre-cancerous viral infection.
165 . The composition of claim 158 , wherein the composition is used for destroying Hepatitis B virus particles in a mammal infected with Hepatitis B prior to the onset of liver cancer in said infected mammal.
166 . The composition of claim 158 , wherein the composition is used for destroying Hepatitis C virus particles in a mammal infected with Hepatitis C prior to the onset of liver cancer in said infected mammal.
167 . The composition as in claim 158 wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
168 . The composition as in claim 158 wherein said virus is Epstein-Barr Virus and said cancer is Burkitt's lymphoma.
169 . The composition as in claim 158 wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.
170 . A chemical composition for treating at least one pre-cancerous affecting virus causing cancer in mammals comprising: a compound of synergistic components of a fixed compound of copper and iron to form a core particle, said core particle targeting said virus without affecting the surrounding environment.
171 . The composition as in claim 170 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
172 . The composition as in claim 170 wherein said affecting virus is selected from the group consisting of Hepatitis B virus and Hepatitis C virus.
173 . The composition as in claim 170 wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
174 . The composition as in claim 170 wherein said virus is Epstein-Barr Virus (EBV) and said cancer is Burkitt's lymphoma.
175 . The composition as in claim 170 wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.
176 . A method for treating precancerous Virus infection and prevention of cancer in a patient comprising: forming a colloidal solution composition of at least a fixed copper compound core, and said fixed copper compound core being encapsulated, encoated, adsorbed, complexed or bound in at least one of a sheath, a shell, a polymeric shell, a cover, a casing, an encoating, a jacket or combination thereof, and a pharmaceutically acceptable carrier, said sheath, shell, polymeric shell, cover, casing, encoating, jacket or combination thereof being made of a material targeting at least one precancerous virus, and preventing immediate chemical interaction of the core with the surrounding cellular environment; said fixed copper compound core further comprising a material that remains in circulation of the mammals, wherein said targeting of said virus is used for prevention of cancer.
177 . The composition as in claim 176 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
178 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for therapeutic treatment of hepatitis B virus.
179 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis B viral infection.
180 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for therapeutic treatment of hepatitis C virus.
181 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for preventive pre-acute stage treatment of hepatitis C viral infection.
182 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for therapeutic treatment of pre-cancerous viral infection.
183 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for destroying Hepatitis B virus particles in a mammal infected with Hepatitis B prior to the onset of liver cancer in said infected mammal.
184 . The method for treating precancerous hepatocellular Virus infection and prevention of liver cancer of claim 176 , wherein the composition is used for destroying Hepatitis C virus particles in a mammal infected with Hepatitis C prior to the onset of liver cancer in said infected mammal.
185 . The composition as in claim 176 wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
186 . The composition as in claim 176 wherein said virus is Epstein-Barr Virus (EBV) and said cancer is Burkitt's lymphoma.
187 . The composition as in claim 176 wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.
188 . The method of claim 176 further comprising the steps of administering the colloidal solution composition to a patient; monitoring the presence of said hepatocellular virus in the patient; and re-administering the composition at intervals based on results of the monitoring.
189 . A method for treating an affecting virus and preventing cancer comprising the steps of administering a compound of synergistic components of fixed copper and fixed iron to a patient infecting with at least one pre-cancerous virus.
190 . The composition as in claim 189 where said virus is a hepatocellular affecting virus and said cancer is liver cancer.
191 . The method as in claim 189 wherein said hepatocellular affecting virus is selected from the group consisting of Hepatitis B virus and Hepatitis C virus.
192 . The composition as in claim 189 wherein said virus is human papilloma virus (HPV) and said cancer is cervical cancer.
193 . The composition as in claim 189 wherein said virus is Epstein-Barr Virus (EBV) and said cancer is Burkitt's lymphoma.
194 . The composition as in claim 189 wherein said virus is Human T-cell Lymphotropic Virus (HTLV-1) and said cancer is Adult T-cell Leukemia/Lymphoma.Join the waitlist — get patent alerts
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