Methods of identifying compounds that modulate il-4 receptor-mediated ige synthesis utilizing an adenosine kinase

Abstract

The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

1 . A method of identifying a compound that modulates IL4 receptor-mediated IgE production or a process associated therewith, comprising determining whether the compound binds An adenosine kinase, wherein the ability to bind the adenosine kinase identifies the compound as being a modulator of IL-4 induced IgE production or a process associated therewith.  
     
     
         2 - 52 . (canceled)