Multi-carotenoids compositions and uses therefor

Abstract

A stable nutritional supplement composition for oral administration comprising about 71% by weight, of a tomato extract containing therein at least 2% to 10% by weight of lycopene, 0.25% to 2% by weight of phytoene, and 0.2% to 2% by weight of phytofluene, and about 29% by weight, of a suitable encapsulating matrix. A suitable encapsulating matrix is an edible oil exemplified by soya oil, pumpkin seed oil, grape-seed oil and the like. The tomato extract may additionally comprise one or more of at least one carotene selected from the group comprising β-carotene, γ-carotene, and δ-carotene, a phytosterol, a tocopheral and a phospholipid. The tomato extract may be further processed into oleoresin emulsions, or into beadlets, or into dry powders. Methods for ameliorating the effects of aging-related urinary tract malfunctions in men, comprising orally administrating on a regular basis, an effective amount of the nutritional supplement compositions disclosed herein.

1 . A stable nutritional supplement composition for oral administration, said composition comprising: 
 a tomato extract comprising at least 2% to 10% by weight of lycopene, 0.25% to 2% by weight of phytoene, and 0.2% to 2% by weight of phytofluene;    an edible oil; and    a suitable carrier.    
   
   
       2 . A nutritional supplement composition according to  claim 1 , wherein the tomato extract additionally comprises at least one carotene selected from the group comprising β-carotene, γ-carotene, and δ-carotene, a phytosterol, a tocopheral and a phospholipid.  
   
   
       3 . A nutritional supplement composition according to  claim 1 , wherein said edible oil is selected from the group comprising soya oil, pumpkin seed oil, grape-seed oil and the like.  
   
   
       4 . A nutritional supplement composition according to  claim 1 , wherein said extract is further processed into a formulation component selected from the group comprising oleoresins, beadlets and dry powders.  
   
   
       5 . A nutritional supplement composition according to  claim 1 , wherein said carrier is selected from the group comprising soft gel capsules, hard capsules, sachet packets, and tablets.  
   
   
       6 . A nutritional supplement composition according to  claim 3 , wherein said carrier is selected from the group comprising soft gel capsules, hard capsules, sachet packets, and tablets.  
   
   
       7 . A nutritional supplement composition according to  claim 1 , wherein the tomato extract comprises 4% to 6% by weight of lycopene, 0.4% to 0.6% by weight of phytoene, and 0.3% to 0.5% by weight of phytofluene.  
   
   
       8 . A nutritional supplement composition according to  claim 7 , wherein the tomato extract additionally comprises at least one carotene selected from the group comprising β-carotene, γ-carotene, and δ-carotene, a phytosterol, a tocopheral and a phospholipid.  
   
   
       9 . A nutritional supplement composition according to  claim 8 , wherein: 
 the tomato extract comprises 4% to 7% by weight of lycopene, 0.4% to 0.7% by weight of phytoene; 0.3% to 0.6% by weight of phytofluene, 1% to 3% by weight of a tocopherol, 1% to 2% by weight of a β-carotene, 0.3% to 0.6% by weight of a phytosterol, 5% to 10% by weight of a phospholipid;    said tomato extract combined with an edible oil; and    said combined tomato extract and edible oil is encased within a soft gel capsule.    
   
   
       10 . A nutritional supplement composition according to  claim 9 , wherein said edible oil is selected from the group comprising soya oil, pumpkin seed oil, grape-seed oil and the like.  
   
   
       11 . A method for ameliorating the effects of aging-related urinary tract malfunctions in men, said urinary tract malfunctions comprising the group of benign prostrate hyperplasia, lower urinary tract symptoms and prostrate cancer, the method comprising orally administrating on a regular basis, an effective amount of the nutritional supplement composition of  claim 1 .  
   
   
       12 . A method according to  claim 11 , wherein the regular oral administration of said nutritional supplement composition provides a daily nutritional supplement of at least 15 mg lycopene.  
   
   
       13 . A method for ameliorating the effects of aging-related urinary tract malfunctions in men, said urinary tract malfunctions comprising the group of benign prostrate hyperplasia, lower urinary tract symptoms and prostrate cancer, the method comprising orally administrating on a regular basis, an effective amount of the nutritional supplement composition of  claim 4 .  
   
   
       14 . A method according to  claim 13 , wherein the regular oral administration of said nutritional supplement composition provides a daily nutritional supplement of at least 15 mg lycopene.  
   
   
       15 . A method for ameliorating the effects of aging-related urinary tract malfunctions in men, said urinary tract malfunctions comprising the group of benign prostrate hyperplasia, lower urinary tract symptoms and prostrate cancer, the method comprising orally administrating on a regular basis, an effective amount of the nutritional supplement composition of  claim 9 .  
   
   
       16 . A method according to  claim 15 , wherein the regular oral administration of said nutritional supplement composition provides a daily nutritional supplement of at least 15 mg lycopene.