Anti-inflammatory cranberry flavonol extract preparations

Abstract

The present invention is directed to extracts of cranberries ( Vaccinium macrocarpon ) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-β-xylopyranoside, quercetin-3-β-glucoside, quercetin-3-α-arabinopyranoside, 3′-methoxyquercetin-3-α-xylopyranoside, quercetin-3-O-(6″-p-coumaroyl)-β-galactoside, and quercetin-3-O-(6″-benzoyl)-β-galactoside. The present invention also embodies the use of those extracts, as well as extracts comprising the cranberry flavonol compound quercetin-3-α-arabinofuranoside, for the treatment of inflammatory disorders. Pharmaceutical, food, dietary supplement, and cosmetic compositions utilizing the extracts or compounds of the present invention are also recited.

1 . A flavonol composition comprising an extract of cranberry flavonols, the extract being substantially free of anthocyanins and proanthocyanidins, wherein each of the cranberry flavonols includes pharmaceutically acceptable salts thereof.  
   
   
       2 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the flavonol composition of  claim 1 .  
   
   
       3 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier in admixture with the flavonol composition of  claim 1 .  
   
   
       4 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the pharmaceutical composition of  claim 3 .  
   
   
       5 . A dietary supplement composition comprising a consumable carrier in admixture with the flavonol composition of  claim 1 .  
   
   
       6 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the dietary supplement composition of  claim 5 .  
   
   
       7 . A food composition comprising a consumable carrier in admixture with the flavonol composition of  claim 1 .  
   
   
       8 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the food composition of  claim 7 .  
   
   
       9 . The food composition of  claim 7  wherein the consumable carrier is a cranberry-containing food product.  
   
   
       10 . The food composition of  claim 9  wherein the cranberry-containing food product is a dried cranberry, a sweetened and dried cranberry, a powdered cranberry, a flavored fruit piece, a sauce, a jelly, a relish, a juice, a wine or a cranberry juice-containing product.  
   
   
       11 . The food composition of  claim 7  wherein the consumable carrier is a beverage.  
   
   
       12 .- 23 . (canceled)  
   
   
       24 . A compound having the formula as shown, including pharmaceutically acceptable salts thereof:  
     
       
         
         
             
             
         
       
     
   
   
       25 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the compound of  claim 24 , including pharmaceutically acceptable salts thereof.  
   
   
       26 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier in admixture with the compound of  claim 24 .  
   
   
       27 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the pharmaceutical composition of  claim 26 .  
   
   
       28 . A dietary supplement composition comprising a consumable carrier in admixture with the compound of  claim 24 .  
   
   
       29 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the dietary supplement composition of  claim 28 .  
   
   
       30 . A food composition comprising a consumable carrier in admixture with the compound of  claim 24 .  
   
   
       31 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the food composition of  claim 30 .  
   
   
       32 . The food composition of  claim 30  wherein the consumable carrier is a cranberry-containing food product.  
   
   
       33 . The food composition of  claim 32 , wherein the cranberry-containing food product is a dried cranberry, a sweetened and dried cranberry, a powdered cranberry, a flavored fruit piece, a sauce, a jelly, a relish, a wine or a cranberry juice-containing product.  
   
   
       34 . The food composition of  claim 30 , wherein the consumable carrier is a beverage.  
   
   
       35 . A cosmetic composition comprising a cosmetically acceptable carrier in admixture with the flavonol composition of  claim 1 .  
   
   
       36 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the cosmetic composition of  claim 35 .  
   
   
       37 .- 38 . (canceled)  
   
   
       39 . A cosmetic composition comprising a cosmetically acceptable carrier in admixture with the compound of  claim 24 .  
   
   
       40 . A method for the prevention and treatment of an inflammatory condition comprising administration of a therapeutically effective dose of the cosmetic composition of  claim 39.