US2007270465A1PendingUtilityA1

Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl) piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride

Individually held — no corporate assignee on recordPriority: Jul 12, 2002Filed: Jul 11, 2007Published: Nov 22, 2007

Est. expiryJul 12, 2022(expired)· nominal 20-yr term from priority

Inventors:Julie Kay Bush Margaret Mary Faul Susan Marie Reutzel-Edens

A61P 35/00A61P 43/00C07D 401/14

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References

Claims

Abstract

The present invention relates to crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-yl-methyl)piperidin-4-yl)]-1H-pyrrole mono-hydrochloride salt, a pharmaceutical formulation containing said salt and to methods for treating cancer and for inhibiting tumor growth using said salt.

Claims

exact text as granted — not AI-modified

1 - 4 . (canceled)  
   
   
       5 . A method of treating non-Hodgkins lymphoma which comprises administering to a mammal in need thereof an effective amount of crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride having an X-ray diffraction pattern which comprises the following peaks: 6.8±0.1, 10.9±0.1, 14.2±0.1 and 16.6±0.1° in 2θ; when the pattern is obtained from a copper radiation source (CuKα;λ=1.54056 Å).  
   
   
       6 . A method of treating glioblastoma which comprises administering to a mammal in need thereof an effective amount of crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride having an X-ray diffraction pattern which comprises the following peaks: 6.8±0.1, 10.9±0.1, 14.2±0.1 and 16.6±0.1° in 2θ; when the pattern is obtained from a copper radiation source (CuKα; λ=1.54056 Å).  
   
   
       7 . A method of treating non-small cell lung cancer which comprises administering to a mammal in need thereof an effective amount of crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole mono-hydrochloride having an X-ray diffraction pattern which comprises the following peaks: 6.8±0.1, 10.9±0.1, 14.2±0.1 and 16.6±0.1° in 2θ; when the pattern is obtained from a copper radiation source (CuKα; λ=1.54056 Å).  
   
   
       8 - 14 . (canceled)

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