Uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid

Abstract

The present invention relates to a method for maintaining a healthy bone structure by administering to a patient a bone health promoting effective amount of a medicament containing 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its soluble salts or any of its hydrates.

1 . A method for stimulation of those signaling cascades and reaction mechanisms mediating the action of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, or any of its soluble salts or any of its hydrates, which can be blocked by Ca 2+ -channel blockers, said method comprising administration of stimulating effective amount of a medicament comprising 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, or any of its soluble salts or any of its hydrates.  
   
   
       2 . A method according to  claim 1 , wherein the Ca 2+ -channel blockers are selected from the group comprising nifedipine and verapamil.  
   
   
       3 . A method according to  claim 1 , wherein 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its soluble salts or any of its hydrates, is administered in doses of 0.01 to 1000 mg/oral application.  
   
   
       4 . A method according to  claim 3 , wherein 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its soluble salts or any of its hydrates, is administered in doses of 12.5 to 75 mg/oral application.  
   
   
       5 . A method according to  claim 1 , wherein 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its soluble salts or any of its hydrates, is administered in doses of 0.02 to 200 mg/parenteral application.  
   
   
       6 . A method according to  claim 5 , wherein 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its soluble salts or any of its hydrates, is administered in doses of 2.5 to 15 mg/parenteral application.  
   
   
       7 . A method for mobilization of Ca 2+ -ions from IP 3 -sensitive stores, said method comprising administering a Ca 2+ -ion mobilizing effective amount of a medicament comprising 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its soluble salts or any of its hydrates.