Rapidly disintegrable solid preparation

Abstract

A rapidly disintegrable solid preparation which comprises (i) a pharmacologically active ingredient, (ii) a sugar and (iii) a low-substituted hydroxypropylcellulose having 5 % by weight or more to less than 7 % by weight of hydroxypropoxyl group. The rapidly disintegrable solid preparation has fast disintegrability, suitable strength and no roughness.

1 . An orally rapidly disintegrable solid preparation which comprises (i) a pharmacologically active ingredient, (ii) a sugar and (iii) a low-substituted hydroxypropylcellulose having 5% by weight or more to less than 7% by weight of hydroxypropoxyl group, wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.  
   
   
       2 . (canceled)  
   
   
       3 . A preparation of  claim 1 , which is a tablet.  
   
   
       4 . A preparation of  claim 1 , wherein the sugar is a sugar alcohol.  
   
   
       5 . A preparation of  claim 4 , wherein the sugar alcohol is mannitol or erythritol.  
   
   
       6 . A preparation of  claim 1 , wherein the sugar is in an amount of 5 to 97 parts by weight per 100 parts by weight of the solid preparation.  
   
   
       7 . A preparation of  claim 1 , wherein the low-substituted hydroxypropylcellulose having 5% by weight or more to less than 7% by weight of hydroxypropoxyl group is used in an amount of 3 to 50 parts by weight per 100 parts by weight of the solid preparation.  
   
   
       8 . (canceled)  
   
   
       9 . A preparation of  claim 1 , wherein the pharmacologically active ingredient is voglibose.  
   
   
       10 . (canceled)  
   
   
       11 . (canceled)  
   
   
       12 . A preparation of  claim 1 , wherein the pharmacologically active ingredient is candesartan cilexetil.  
   
   
       13 . A preparation of  claim 3  which comprises fine granules.  
   
   
       14 . A preparation of  claim 13 , wherein the pharmacologically active ingredient is comprised in fine granules of the solid preparation.  
   
   
       15 . A preparation of  claim 14 , wherein (i) a sugar and (ii) a low-substituted hydroxypropylcellulose having 5% by weight or more to less than 7% by weight of hydroxypropoxyl group are comprised in the solid preparation separately from fine granules.  
   
   
       16 . A preparation of  claim 15 , wherein the sugar is in an amount of 5 to 97 parts by weight per 100 parts by weight of the rest of the solid preparation other than the fine granules.  
   
   
       17 . A preparation of the  claim 15 , wherein the low-substituted hydroxypropylcellulose having 5% by weight or more to less than 7% by weight of hydroxypropoxyl group is in an amount of 3 to 50 parts by weight per 100 parts by weight of the rest of the solid preparation other than the fine granules.  
   
   
       18 . (canceled)  
   
   
       19 . (canceled)