Treatment for Cardiovascular Disease

Abstract

This invention relates to a method for treating and preventing hypertension by administering a therapeutically effective amount of an agent capable of reducing uric acid levels in a patient in need of such treatment. Additionally, the scope of the invention includes a method of treating coronary heart disease by administering a therapeutically effective amount of an agent capable of reducing uric acid levels in a patient in need of such treatment.

1 .- 13 . (canceled)  
   
   
       14 . A pharmaceutical composition comprising a renin angiotensin system (RAS) inhibitor, or pharmaceutically acceptable salt thereof and allopurinol, or pharmaceutically acceptable salt thereof, and a pharmaceutical carrier.  
   
   
       15 . The pharmaceutical composition as recited in  claim 14 , further comprising a diuretic, or pharmaceutically acceptable salt thereof  
   
   
       16 . The pharmaceutical composition as recited in  claim 15 , wherein said diuretic is hydrochlorothiazide.  
   
   
       17 . A pharmaceutical composition comprising a renin angiotensin system (RAS) inhibitor, or pharmaceutically acceptable salt thereof, allopurinol, or a pharmaceutically acceptable salt thereof, hydrochlorothiazide, or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier.  
   
   
       18 . A pharmaceutical composition comprising a renin angiotensin system (RAS) inhibitor, or pharmaceutically acceptable salt thereof and the agent, or pharmaceutically acceptable salt thereof, capable of reducing uric acid levels and a pharmaceutical carrier; wherein said agent is a xanthine oxidase inhibitor; a uricosuric agent; supplements of the uricase protein or a urate channel inhibitor, or pharmaceutically acceptable salts, or combinations thereof.  
   
   
       19 . The pharmaceutical composition as recited in  claim 17 , further comprising a diuretic, or pharmaceutically acceptable salt thereof.