Method for the improvement of neuronal regeneration

Abstract

A method for the improvement of neuronal regeneration by prevention or inhibition of basal membrane formation induced by a lesion of neuronal tissue.

1 - 17 . (canceled)  
   
   
       18 . A method of enhancing regeneration of injuries caused by a lesion of neuronal tissue comprising local administration of an inhibitor of basal membrane formation to enhance axonal regeneration by specific inhibition of basal membrane formation induced.  
   
   
       19 . The method according to  claim 18 , wherein the inhibitor is selected from the group consisting of antibodies against collagen IV; Fe-chelating agents; inhibitors of amino acids hydroxylases, such as prolyl-4-hydroxylase, lysine-hydroxylase; 2-oxoglutarate competitiors; antisense oligo nucleotides or oligo nucleotide analogs; siRNAs; aptamers.  
   
   
       20 . The method of  claim 19 , wherein the inhibitor is selected from the group consisting of pyridine derivatives, such as 5-arylcarbonylamino- or 5-arylcarbamoyl-derivatives, 2-carboxylate, 2,5, dicarboxylate, their ethyl esters or ethyl amides, or dimethoxylamides; 3,4′-bipyridine, such as 5 amino-6-(1H)-one, 1,6-dihydro-2-methyl-6-oxo-5-carbonitril; 2,2′-dipyridine, such as 5,5′-dicarboxylic acid or its pharmaceutically acceptable salts, 4,4′-dicarboxylic acid ethyl ester or ethyl amide; 3,4′-dihydroxybenzoate, such as the diethyl ester; proline and its structural and functional analoges; β-aminopropionitrile; desferrioxamine; desferasirox; anthracyclines; 2,7,8-trihydroxy anthraquinones, fibrostatin-C; coumalic acid or its pharmaceutically acceptable salts; 5-oxaproline, β-lactam antibiotics.  
   
   
       21 . The method of  claim 18 , wherein the inhibitor is administered in combination with a substance that stimulates neuronal growth.  
   
   
       22 . The method of  claim 19 , wherein the inhibitor is administered in combination with a substance that stimulates neuronal growth.  
   
   
       23 . The method of  claim 20 , wherein the inhibitor is administered in combination with a substance that stimulates neuronal growth.  
   
   
       24 . The method of  claim 18 , wherein the inhibitor is administered in an amount in an amount of 1 ng/kg to 1 mg/kg body weight.  
   
   
       25 . The method of  claim 19 , wherein the inhibitor is administered in an amount of 1 ng/kg to 1 mg/kg body weight.  
   
   
       26 . The method of  claim 20 , wherein the inhibitor is administered in an amount of 1 ng/kg to 1 mg/kg body weight.  
   
   
       27 . The method of  claim 21 , wherein the inhibitor is administered in an amount of 1 ng/kg to 1 mg/kg body weight.  
   
   
       28 . The method of  claim 22 , wherein the inhibitor is administered in an amount of 1 ng/kg to 1 mg/kg body weight.  
   
   
       29 . The method of  claim 23 , wherein the inhibitor is administered to an amount of 1 ng/kg to 1 mg/kg body weight.