US2007225341A1PendingUtilityA1

Nicotinic Acid Compositions For Treating Hyperlipidemia and Related Methods Therefor

71
Individually held — no corporate assignee on recordPriority: Sep 20, 1993Filed: Jun 4, 2007Published: Sep 27, 2007
Est. expirySep 20, 2013(expired)· nominal 20-yr term from priority
Inventors:David J. Bova
A61K 31/455A61K 9/2054A61K 9/2077A61P 3/06A61K 31/44A61K 9/2027A61P 7/00A61P 3/10
71
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treating hyperlipidemia in a hyper lipidemic having a substantially periodic physiological loss of consciousness, includes the steps of forming a composition having an effective antihyperlipidemic amount of nicotinic acid and a time release sustaining amount of a swelling agent. The method also includes the step of orally administering the composition to the hyperlipidemic once per day “nocturnally,” that is in the evening or at night.

Claims

exact text as granted — not AI-modified
1 . (canceled)  
     
     
         2 . (canceled)  
     
     
         3 . (canceled)  
     
     
         4 . (canceled)  
     
     
         5 . (canceled)  
     
     
         6 . (canceled)  
     
     
         7 . (canceled)  
     
     
         8 . (canceled)  
     
     
         9 . (canceled)  
     
     
         10 . (canceled)  
     
     
         11 . (canceled)  
     
     
         12 . (canceled)  
     
     
         13 . A method for treating hyperlipidermia in a hyperlipidermic, the method comprising the step of: 
 dosing the hyperlipidemic with a sustained release oral solid dosage form comprising about 500 mg to about 3000 mg nicotinic acid once per day and wherein the antihyperlipidemic's total cholesterol, LDL cholesterol, triglycerides and Lp(a) are reduced and the antihyperlipidemic's HDL cholesterol is increased.    
     
     
         14 . The method according to  claim 13 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         15 . The method according to  claim 32 , wherein the increase in HDL cholesterol is at least 20% from baseline after at least eight weeks of said administration.  
     
     
         16 . The method according to  claim 15 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         17 . The method according to  claim 32 , wherein the increase in HDL cholesterol is at least 25% from baseline after at least eight weeks of said administration.  
     
     
         18 . The method according to  claim 17 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         19 . The method according to  claim 32 , wherein the reduction in LDL cholesterol is at least 10% from baseline after at least eight weeks of said administration.  
     
     
         20 . The method according to  claim 19 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         21 . The method according to  claim 32 , wherein the reduction in LDL cholesterol is at least 12% from baseline after at least eight weeks of said administration.  
     
     
         22 . The method according to  claim 21 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         23 . The method according to  claim 32 , wherein the reduction in LDL cholesterol is at least 13% from baseline after at least eight weeks of said administration.  
     
     
         24 . The method according to  claim 23 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         25 . The method according to  claim 32 , wherein the reduction in total cholesterol is at least 8% from baseline after at least eight weeks of said treatment.  
     
     
         26 . The method according to  claim 25 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         27 . The method according to  claim 32 , wherein the reduction in Lp(a) is at least 15% from baseline after at least eight weeks of said treatment.  
     
     
         28 . The method according to  claim 27 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         29 . The method according to  claim 13 , wherein the dosage form contains about 500 mg nicotinic acid.  
     
     
         30 . The method according to  claim 13 , wherein the dosage form contains about 750 mg nicotinic acid.  
     
     
         31 . The method according to  claim 13 , wherein the dosage form contains about 1000 mg nicotinic acid.  
     
     
         32 . The method according to  claim 13 , wherein the dosage form contains about 1500 mg nicotinic acid.  
     
     
         33 . The method according to  claim 13 , wherein the dosage form contains about 2000 mg nicotinic acid.  
     
     
         34 . The method according to  claim 13 , wherein the dosage form contains about 3000 mg nicotinic acid.  
     
     
         35 . The method according to  claim 29 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         36 . The method according to  claim 30 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         37 . The method according to  claim 31 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         38 . The method according to  claim 32 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         39 . The method according to  claim 33 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         40 . The method according to  claim 34 , wherein the hyperlipidemic is dosed at night or in the evening.  
     
     
         41 . The method according to claims  13 ,  14 ,  16 ,  18 ,  20 ,  22 ,  24 ,  26 ,  28 ,  35 ,  36 ,  37 ,  38 ,  39  or  40 , wherein the dosage form is administered to the hyperlipidemic with food.

Join the waitlist — get patent alerts

Track US2007225341A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.