Inhibition of Syk kinase expression

Abstract

The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).

1 . A method of inhibiting expression of Syk kinase in a cell comprising introducing into said cell small interfering RNA (siRNA) molecules that direct cleavage of a target Syk kinase mRNA sequence present in said cell thereby effecting said inhibition.  
     
     
         2 - 18 . (canceled)  
     
     
         19 . An siRNA molecule comprising a sequence complementary to a sequence selected from the group consisting of:  
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   AATATGTGAAGCAGACATGGA, 
                     
                 
                     
                     
                 
                     
                   AATCAAATCATACTCCTTCCC, 
                 
                     
                     
                 
                     
                   AAGAGAGTACTGTGTCATTCA, 
                 
                     
                     
                 
                     
                   AAGGAAAACCTCATCAGGGAA, 
                 
                     
                     
                 
                     
                   AATCATACTCCTTCCCAAAGC, 
                 
                     
                     
                 
                     
                   AATTTTGGAGGCCGTCCACAA, 
                 
                     
                     
                 
                     
                   AAGACTGGGCCCTTTGAGGAT, 
                 
                     
                     
                 
                     
                   AAGCAGACATGGAACCTGCAG, 
                 
                     
                     
                 
                     
                   AACTTCCAGGTTCCCATCCTG, 
                 
                     
                     
                 
                     
                   AAGCCTGGCCACAGAAAGTCC, 
                 
                     
                     
                 
                     
                   AAGCCCTACCCATGGACACAG, 
                 
                     
                     
                 
                     
                   AACCTGCAGGGTCAGGCTCTG, 
                 
                     
                     
                 
                     
                   AAGGGGTGCAGCCCAAGACTG, 
                 
                     
                     
                 
                     
                   AACTTGCACCCTGGGCTGCAG, 
                 
                     
                     
                 
                     
                   AAGTCCTCCCCTGCCCAAGGG, 
                 
                     
                     
                 
                     
                   AAGGCCCCCAGAGAGAAGCCC, 
                 
                     
                     
                 
                     
                   AATCTCAAGAATCAAATCATA, 
                 
                     
                     
                 
                     
                   AATGTTAATTTTGGAGGCCGT, 
                 
                     
                     
                 
                     
                   AATCCGTATGAGCCAGAACTT, 
                 
                     
                     
                 
                     
                   AATCGGCACACAGGGAAATGT, 
                 
                     
                     
                 
                     
                   AACCGGCAAGAGAGTACTGTG, 
                 
                     
                     
                 
                     
                   AAGGAGGTTTACCTGGACCGA, 
                 
                     
                   and 
                 
                     
                     
                 
                     
                   AACCTCATCAGGGAATATCTG. 
                 
                     
                     
                 
             
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         20 . A composition comprising the siRNA molecule according to  claim 19  and a carrier.  
     
     
         21 . A composition comprising the siRNA molecule according to  claim 19  and a liposome or polymer.