Pharmaceutical compositions

Abstract

This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporin or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.

1 - 5 . (canceled)  
   
   
       6 . A pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.  
   
   
       7 . A composition as claimed in  claim 6  wherein the acid is a mono-, di-, or tri-carboxylic acid.  
   
   
       8 . A composition as claimed in  claim 6  wherein the acid is selected from malonic acid, oxalic acid, citric acid and lactic acid.  
   
   
       9 . Use of an acid to stabilize a macrolide in a pharmaceutical composition.  
   
   
       10 . A method of stabilizing a macrolide in a pharmaceutical composition, which method comprises mixing an acid with the macrolide.