Compounds for treating inflammatory diseases

Abstract

The invention relates to the use of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0 2,4 ]nonane salts for preparing a pharmaceutical composition for the prevention and treatment of diseases associated with inflammation.

1 . A method for treating disease in a warm-blooded animal which disease is associated with an inflammatory process which method comprises administering to the animal a therapeutically effective amount of a salt of tiotropium.  
   
   
       2 . The method as recited in  claim 1  wherein the disease involves upper or lower or both respiratory organs.  
   
   
       3 . The method as recited in  claim 1  wherein the disease is selected from allergic rhinitis, non-allergic rhinitis, chronic rhinitis, bronchiectasis, cystic fibrosis, asthma, COPD, idiopathic lung fibrosis and fibrosing alveolitis.  
   
   
       4 . The method as recited in  claim 1  wherein the disease is selected from dermatitis, urticaria and inflammatory bowel disease.  
   
   
       5 . The method as recited in  claim 1  wherein the tiotropium salt is selected from chloride, bromide, iodide, methanesulphonate, paratoluenesulphonate and methylsulphate.  
   
   
       6 . The method as recited in  claim 5  wherein the tiotropium salt is methanesulphonate, chloride, bromide or iodide.  
   
   
       7 . The method as recited in  claim 6  wherein the tiotropium salt is methanesulphonate or bromide.  
   
   
       8 . The method as recited in  claim 1  wherein the tiotropium salt is administered via inhalation.