Integrin-linked kinase and its uses

Abstract

Methods for isolating ILK genes are provided. The ILK nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

1 .- 21 . (canceled)  
     
     
         22 . A purified polypeptide composition comprising at least 50% by weight of the protein present as integrin linked kinase, wherein said polypeptide is encoded by an isolated nucleic acid that will hybridize to the nucleotide sequence set forth in SEQ ID NO:22 under the following conditions: 0.1×SSC (9 mM saline/0.9 mM sodium citrate) at 50° C. or higher.