Methods of using two-part self-adhering dental compositions

Abstract

A method for providing a dental composition comprising providing a paste/paste two-part self-adhering dental composition comprising (a) at least one acidic compound containing at least one acidic moiety selected from the group consisting of where R is an alkyl or aryl group; (b) at least one polymerizable monomer without any acidic group where the polymerizable group is selected from the group consisting of an acrylate, a methacrylate and a vinyl group; (c) at least one finely divided filler; (d) a reducing agent; and (e) an oxidizing agent; and providing instructions for mixing the two pastes immediately prior to application where the ratio of a first paste containing (a) or a higher concentration of (a) to a second paste not containing (a) or containing a lower concentration of (a) is greater than 1:1 (by volume). The method also includes mixing the two pastes and applying the mixed composition to a dental substrate.

1 . A method for providing a dental composition comprising 
 providing a paste/paste two-part self-adhering dental composition comprising 
 (a) at least one acidic compound containing at least one acidic moiety selected from the group consisting of  
                     
   where R is an alkyl or aryl group; 
 (b) at least one polymerizable monomer without any acidic group where the polymerizable group is selected from the group consisting of an acrylate, a methacrylate and a vinyl group;  
 (c) at least one finely divided filler; having a mean particle size less than 50 microns;  
 (d) at least one reducing agent; and  
 (e) at least one oxidizing agent;  
   providing instructions for mixing the two pastes and applying the mixed composition to a dental substrate wherein the ratio of a first paste containing (a) or a higher concentration of (a) to a second paste not containing (a) or containing a lower concentration of (a) is greater than 1:1 (by volume).    
   
   
       2 . The method of  claim 1  further comprising mixing the two pastes, applying the mixed composition to a dental substrate, and hardening the composition inside a patient's mouth.  
   
   
       3 . The method of  claim 1  wherein the composition further comprises at least one component selected from the group consisting of a photo-initiator, a stabilizer, a solvent, and combinations thereof.  
   
   
       4 . The method of  claim 1  wherein the filler is selected from the group consisting of inorganic metal, salt, oxide, nitride, silicate glass, aluminosilicate glass, aluminoborosilicate glass, fluoroaluminosilicate glass, quartz, colloidal silica, precipitated silica, zirconia-silica, polymeric filler, polymerized composite filler with inorganic particles, and combinations thereof.  
   
   
       5 . The method of  claim 4  wherein the metal, salt, oxide, silicate glass, aluminosilicate glass, aluminoborosilicate glass, and fluoroaluminosilicate glass contains an element selected from the group consisting of Sr, Y, Zr, Ba, La, Hf, Zn, Bi, W, a rare earth metal, and combinations thereof.  
   
   
       6 . The method of  claim 3  wherein the solvent is selected from the group consisting of water, acetone, methanol, ethanol, isopropanol, ethylene glycol, glycerin, or combinations thereof.  
   
   
       7 . The method of  claim 1  wherein the acidic compound is a polymerizable monomer with at least one ethylenically unsaturated group selected from the group consisting of an acrylate, a methacrylate and a vinyl group.  
   
   
       8 . The method of  claim 7  wherein the acidic polymerizable monomer contains at least one phosphate group.  
   
   
       9 . The method of  claim 7  wherein the acidic polymerizable monomer is selected from the group consisting of HEMA-P, GDM-P, Bis(HEMA)-P, MDP, phenyl-P, PENTA-P, or combinations thereof.  
   
   
       10 . The method of  claim 1  wherein the acidic compound is a homopolymer or copolymer of an α,β-unsaturated carboxylic acid.  
   
   
       11 . The method of  claim 10  wherein the α,β-unsaturated carboxylic acid is selected from the group consisting of acrylic acid, methacrylic acid, maleic acid, and itaconic acid.  
   
   
       12 . The method of  claim 10  wherein the acid homopolymer or copolymer contains at least one ethylenically unsaturated group selected from the group consisting of an acrylate, a methacrylate, and a vinyl group.  
   
   
       13 . The method of  claim 1  wherein the oxidizing agent is selected from the group consisting of a tertiary hydroperoxide compound with at least one hydroperoxide group attached to at least one tertiary carbon, Cu(II) salt, Fe(III) salt, Co(III) salt, persulfate salt, permanganate salt, and combinations thereof.  
   
   
       14 . The method of  claim 1  wherein the oxidizing agent is a tertiary hydroperoxide selected from the group consisting of t-butyl hydroperoxide, t-amyl hydroperoxide, p-diisopropylbenzene hydroperoxide, cumene hydroperoxide, pinane hydroperoxide, p-methane hydroperoxide, 1,1,3,3-tetramethylbutyl hydroperoxide, and combinations thereof.  
   
   
       15 . The method of  claim 1  wherein the reducing agent is selected from the group consisting of aromatic sulfinate salt, aliphatic sulfinate salt, thiourea, substituted thiourea, ascobic acid, ascorbic acid derivative and salt, Fe(II) salt, Cu(I) salt, Co(II) salt, barbituric acid, barbituric acid derivative and salt, thiobarbituric acid, thiobarbituric acid derivative and salt, and combinations thereof.  
   
   
       16 . The method of  claim 1  wherein the reducing agent is a substituted thiourea selected from the group consisting of 1-(2-pyridyl)-2-thiourea, 1-acetyl-2-thiourea, and 1-(2-tetrahydrofufuryl)-2-thiourea.  
   
   
       17 . The method of  claim 1  wherein a first paste comprises the oxidizing agent and a second paste comprises the reducing agent.  
   
   
       18 . The method of  claim 1  wherein one paste comprises an initiator system selected from the group consisting of a reducing agent and an encapsulated oxidizing agent, an oxidizing agent and an encapsulated reducing agent, and an encapsulated oxidizing agent and an encapsulated reducing agent.  
   
   
       19 . The method of  claim 1  wherein the dental substrate is selected from the group consisting of dentine, enamel, dental metal alloy, and porcelain.  
   
   
       20 . The method of  claim 1  wherein the dental composition is selected from the group consisting of a restorative composition, an orthodontic composition, and an endodontic composition.  
   
   
       21 . The method of  claim 1  wherein the dental composition is selected from the group consisting of a dental filling composition, a cement composition, a base/liner composition, a pit/fissure sealant composition, and an adhesive composition.  
   
   
       22 . The method of  claim 1  wherein the dental composition is a cement composition.  
   
   
       23 . The method of  claim 1  wherein the paste/paste two-part self-adhering dental composition is provided from a prepackaged container(s).  
   
   
       24 . The method of  claim 1  wherein the first paste is in a first syringe barrel and the second paste is in a second syringe barrel, the first and second syringes selected from group consisting of two non-joining individual syringes and one dual-syringe assembly.  
   
   
       25 . The method of  claim 24  wherein the ratio of an internal cross-sectional area of the first syringe barrel containing the first paste to the second syringe barrel containing the second paste is in the range of 1.05:1 (by volume) to about 20:1 (by volume).  
   
   
       26 . The method of  claim 25  wherein the relative ratio is in the range of about 2:1 (by volume) to about 10:1 (by volume).  
   
   
       27 . The method of  claim 24  wherein a static mixer with an exit opening is attached to exit openings of the dual-syringe to dispense a substantially homogeneous mixed paste.  
   
   
       28 . The method of  claim 1  wherein the first and second pastes are packaged in single-dose form without contact between the first and second pastes and the ratio of the first paste to the second paste is in the range between 1.05:1 (by volume) to about 20:1 (by volume).  
   
   
       29 . The method of  claim 1  wherein mixing is by a method selected from the group consisting of manual mixing, use of an automated mixing device, and use of a static mixer.  
   
   
       30 . The method of  claim 1  wherein the ratio of the first paste to the second paste is in the range between about 2:1 (by volume) to about 10:1 (by volume).  
   
   
       31 . The method of  claim 1  wherein the mixed composition has a bond strength to an unetched and unprimed dentine substrate selected from the group consisting of at least 3 MPa, at least 5 MPa, and at least 6 MPa.  
   
   
       32 . The method of  claim 1  wherein a total concentration of the at least one acidic compound excluding the filler is selected from the group consisting of at least 10% (w/w), at least 15% (w/w), and at least 20% (w/w).