Use of the neurotoxic component of a botulinum toxin for the treatment of pain associated with muscle activity or contracture

Abstract

A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.

1 . A method for treating a pain associated with a muscle activity or contracture, the method comprising the step of administering to a patient a therapeutically effective amount of the neurotoxic component of a botulinum toxin to thereby treat the pain associated with the muscle activity or contracture, wherein the neurotoxic component administered to the patient has been purified from a botulinum toxin obtained by fermenting  Clostridium botulinum.    
     
     
         2 . The method of  claim 1  wherein the neurotoxic component is the neurotoxic component of a botulinum toxin selected from the group consisting of botulinum toxin types A, B, C, D, E, F and G.  
     
     
         3 . The method of  claim 1 , wherein the botulinum toxin is botulinum toxin type A.  
     
     
         4 . The method of  claim 1 , wherein between about 1 unit and about 250 units of the neurotoxic component is administered.  
     
     
         5 . The method of  claim 1 , wherein alleviation of the pain associated with a muscle activity or contracture occurs in about 1 to about 7 days.  
     
     
         6 . The method of  claim 1 , wherein the neurotoxic component has a molecular weight of about 150 kilodaltons.  
     
     
         7 . The method of  claim 1 , wherein the muscle activity or contracture is a muscle spasm.  
     
     
         8 . The method of  claim 1 , wherein the pain is a low back pain.  
     
     
         9 . The method of  claim 1 , wherein the pain is a myofacial pain.  
     
     
         10 . The method of  claim 1 , wherein the pain is a spasticity pain.  
     
     
         11 . The method of  claim 1 , wherein the pain is a dystonia pain.  
     
     
         12 . The method of  claim 1 , wherein the pain is an arthritis pain.  
     
     
         13 . The method of  claim 1 , wherein the pain is a headache.  
     
     
         14 . The method of  claim 1 , wherein the pain is a sports injury pain  
     
     
         15 . The method of  claim 1 , wherein the pain is secondary to stroke.  
     
     
         16 . The method of  claim 1 , wherein the pain is associated with a smooth muscle spasm.  
     
     
         17 . The method of  claim 16 , wherein the pain is associated with a smooth muscle spasm of a gastrointestinal smooth muscle.  
     
     
         18 . The method of  claim 1 , wherein the neurotoxic component is administered by local administration.  
     
     
         19 . A method for treating a pain associated with a muscle activity or contracture, the method comprising the step of administering to a patient a therapeutically effective amount of the neurotoxic component of only a botulinum toxin type A to thereby treat the pain associated with the muscle activity or muscle contracture, wherein the neurotoxic component administered to the patient has been purified from a botulinum toxin obtained by fermenting a  Clostridium botulinum  bacterium.  
     
     
         20 . The method of  claim 19 , wherein the neurotoxic component has a molecular weight of about 150 kilodaltons.  
     
     
         21 . The method of  claim 19 , wherein the muscle activity or contracture is a muscle spasm.  
     
     
         22 . The method of  claim 19 , wherein the pain is a low back pain.  
     
     
         23 . The method of  claim 19 , wherein the pain is a myofacial pain.  
     
     
         24 . The method of  claim 19 , wherein the pain is a spasticity pain.  
     
     
         25 . The method of  claim 19 , wherein the pain is a dystonia pain.  
     
     
         26 . The method of  claim 19 , wherein the pain is an arthritis pain.  
     
     
         27 . The method of  claim 19 , wherein the pain is a headache.  
     
     
         28 . The method of  claim 19 , wherein the pain is a sports injury pain  
     
     
         29 . The method of  claim 19 , wherein the pain is secondary to stroke.  
     
     
         30 . The method of  claim 19 , wherein the pain is associated with a smooth muscle spasm.  
     
     
         31 . The method of  claim 30 , wherein the pain is associated with a smooth muscle spasm of a gastrointestinal smooth muscle.  
     
     
         32 . The method of  claim 19 , wherein the neurotoxic component is administered by local administration.  
     
     
         33 . A method for treating a pain associated with a muscle activity or contracture, the method comprising the step of administering to a patient a therapeutically effective amount of the neurotoxic component from a single botulinum toxin type to thereby treat the pain associated with the muscle activity or muscle contracture, wherein the neurotoxic component administered to the patient has been purified from a botulinum toxin obtained by fermenting a  Clostridium botulinum  bacterium.  
     
     
         34 . The method of  claim 33 , wherein the botulinum toxin type is selected from the group consisting of the botulinum toxin types A, B, C, D, E, F and G.  
     
     
         35 . The method of  claim 33 , wherein the botulinum toxin type is botulinum toxin type A.  
     
     
         36 . The method of  claim 33 , wherein the neurotoxic component has a molecular weight of about 150 kilodaltons.  
     
     
         37 . The method of  claim 33 , wherein the muscle activity or contracture is a muscle spasm.  
     
     
         38 . The method of  claim 33 , wherein the pain is a low back pain.  
     
     
         39 . The method of  claim 33 , wherein the pain is a myofacial pain.  
     
     
         40 . The method of  claim 33 , wherein the pain is a spasticity pain.  
     
     
         41 . The method of  claim 33 , wherein the pain is a dystonia pain.  
     
     
         42 . The method of  claim 33 , wherein the pain is an arthritis pain.  
     
     
         43 . The method of  claim 33 , wherein the pain is a headache.  
     
     
         44 . The method of  claim 33 , wherein the pain is a sports injury pain  
     
     
         45 . The method of  claim 33 , wherein the pain is secondary to stroke.  
     
     
         46 . The method of  claim 33 , wherein the pain is associated with a smooth muscle spasm.  
     
     
         47 . The method of  claim 46 , wherein the pain is associated with a smooth muscle spasm of a gastrointestinal smooth muscle.  
     
     
         48 . The method of  claim 33 , wherein the neurotoxic component is administered by local administration.