US2007191281A1PendingUtilityA1
Compound containing a labile disulfide bond
Individually held — no corporate assignee on recordPriority: May 16, 1998Filed: Oct 12, 2005Published: Aug 16, 2007
Est. expiryMay 16, 2018(expired)· nominal 20-yr term from priority
C07C 323/62A61K 48/00A61K 31/155C07H 21/04A61K 31/198C07C 323/60C07D 207/46A61K 38/08
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Claims
Abstract
A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
Claims
exact text as granted — not AI-modified1 . A process for delivering a compound having a labile disulfide bond into a mammal, comprising:
a) forming the compound having a disulfide bond selected from the group consisting of (i) a disulfide bond that is cleaved more rapidly than oxidized glutathione, and (ii) a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione, and (iii) a disulfide bond that is activated by intramolecular attack from a free thiol; b) attaching a transduction signal to the compound; c) inserting the compound into the mammal; and, d) releasing the bond between the sulfur atoms in the disulfide.
2 . The process of claim 1 wherein the transduction signal consists essentially of SEQ ID 1.
3 . The process of claim 1 wherein the transduction signal consists of VP22.
4 . The process of claim 1 wherein the transduction signal consists of ANTP.
5 . The process of claim 1 wherein the transduction signal consists of a peptide containing a cationic residues.
6 . The process of claim 1 wherein the transduction signal consists of a polymer containing a plurality of guanidinium groups.Join the waitlist — get patent alerts
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