Kit for automated resolving agent selection and method thereof

Abstract

The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 24, 48, 96 or more samples is examined simultaneously visually or by standard analytical techniques.

1 . A kit for improved identification of the optimal conditions for diasteroisomeric salt crystallization and the selection of the optimal solvents and resolving agents, which kit comprises: 
 A. an array of containers wherein the array is a standard high throughput tray and the containers are a multiplicity of substantially identical containers or well plates each optionally sealed with a sealant or stoppers to avoid loss of chemical solvent,    B. wherein each substantially identical container has a unique combination of resolving agent in each column and at least one suitable solvent in each row; and    C. an instructional text to use said kit.    
   
   
       2 . The kit of  claim 1  wherein the array or tray has at least 24 containers.  
   
   
       3 . The kit of  claim 1  wherein the array or tray has at least 48 containers.  
   
   
       4 . The kit of  claim 1  wherein the array or tray is selected from arrays of the group of at least 96 containers, or 192 containers, or 384 containers or 512 containers.  
   
   
       5 . The kit wherein the array of containers is optionally sealed to exclude air or liquid with at least one sealant.  
   
   
       6 . The kit of  claim 1  wherein the resolving agent, acid or base, is selected from the group consisting of tartaric acid, pyroglutamic acid, di-p-tolulo-tartaric acid, mandelic acid, malic acid, camphorsulphonic acid, dibenzoyl-tartaric acid, deoxycholic acid (+), camphoric acid (+), quinic acid (−), aspartic acid (+), glutamic acid, 1,3,4,6-diisopropylidine-2-ketogluconic acid (−), acetylmandelic acid, N-acetyl-1-hydroxyproline, N-acetyl-1-leucine, acetyl-3-mercapto-2-methylpropionic acid, 3-acetylmercapto-2-methylpropionyl-1-proline, N-acetyl-D-3-(2-naphthyl)-alanine, (R)-acetylthio-2-methylpropionyl chloride, N-acetyl-1-phenylalanine, N-acetyl-1-tyrosinamide, D-alanine, 1-aminoadipic acid, (R)-2-aminobutyric acid, (1R,4S)-4-aminocyclopent-2-ene-1-carboxylic acid, (1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid, S-2-amino-3,3-dimethylbutyric acid, 1-tert-leucine, 1,2-amino-2-methyl-3-(3′,4′-dimethoxyphenyl)-propionitrile HCl, 1-2-amino-2-methyl-3-(3′,4′-dihydroxyphenyl)-propionic acid, (R)-2-amino-4-phenylbutane, D-arginine, D-aspartic acid, D-2-azidophenylacetic acid, D-2-azidophenylacetyl chloride, (1S,2R)-cis-2-benzamido-cyclohexane-carboxylic acid, (1R,2S)-cis-2-benzamido-cyclohexane-carboxylic acid, benzyl-(R) & (S)-mandelate, benzyl-2-tosyloxypropionate, N-2-BOC-D-alanine, N-2-BOC-1-aminoadipic acid, 3-(R)—BOC-aminocyclopent-4-ene-1-(S)-carboxylic acid, 3-(S)—BOC-aminocyclopent-4-ene-1-(R)-carboxylic acid, N-2-BOC-D-arginine hydrochloride, N-2-BOC-D-aspartic acid, N-2-BOC-3-(4-bipheny)alanine, N-2-BOC—N-6-CBZ-D-lysine, N-2-BOC-3-(4-chlorophenyl)-alanine, N-2-BOC-cyclohexylalanine, N-2-BOC-1-cyclohexylalanine methyl ester, N-2-BOC-3,3-diphenylalanine, N-2-BOC-3-(4-fluorophenyl)-alanine, N-2-BOC-D-glutamic acid 1-benzyl ester, N-2-BOC-D-histidine, N-2-BOC-3-(4-iodophenyl)-alanine, N-3-BOC-D-leucine, N-3-BOC-1-tert-leucine DCHA salt, (1S)-camphanic acid, (1R)-camphorsulfonic acid, (1S)-camphorsulfonic acid, 2-methylbenzylamine, N-2-BOC-D-methionine, N-2-BOC-3-(1′-naphtyl)alanine, N-2-BOC-3-(2′-naphtyl)alanine, N-2-BOC-3-(4′-nitrophenyl)alanine, N-2-BOC-1-octahydroindole-2-carboxylic acid, N-2-BOC-3-(pentafluorophenyl)-alanine, N-2-BOC-D-phenylalanine, N—BOC-D-proline, N-1-BOC-D-3-(2′-pyridyl)alanine, N-2-BOC-1-3-(2′-pyridyl)alanine, N-2-BOC-D-3-(3-pyridyl)alanine, N-1-BOC-1-3-(3′-pyridyl)alanine, N-2-BOC-D-serine, N—BOC-1,2,3,4-tetrahydroisoquinoline-(3R)-carboxylic acid, N—BOC-1,2,3,4-tetrahydroisoquinoline-(3S)-carboxylic acid, N-2-BOC-3-(4′-thiazolyl)alanine, N—BOC-D-threonine, N-2-BOC—N-8-tosyl-D-arginine, N-2-BOC-D-tryptophan, N-2-BOC-D-tyrosine, N-2-BOC-D-tyrosine methyl ester, N-2-BOC-D-valine, 2-bromobutyric acid, 2-bromohexadecanoic acid, (R)-2-bromo-2-phenylacetic acid, 2-bromopropionic acid, butyl-(S)-2-chloropropionate, (2R,3S)-butyl-2,3-epoxybutyrate, (R)-butyl-2,3-epoxybutyrate, (S)-tert-butyl-3-hydroxybutyrate, (S)-butyl-lactate, N-butyl-(R)-2-methyl-2-hydrazino-3-(3′-methoxy-4′-hydroxyphenyl)-propionate, N—CBZ-D-alanine, N—CBZ-D-arginine, N—CBZ-D-aspartic acid, N—CBZ-O-tert-butyl-D-serine, CBZ-1-cyclohexylalanine, N—CBZ-D-glutamic acid, N—CBZ-D-histidine, N—CBZ-D-leucine, N—CBZ-1-tert-leucine DCHA salt, N—CBZ-D-methionine, N-2-CBZ-D-3-(2′-naphthyl)alanine, N-2-CBZ-ornithine, N-2-CBZ-D-phenylalanine, N-2-CBZ-D-proline, N-2-CBZ-D-serine, N-2-CBZ-D-threonine, N-2-CBZ-D-tryptophan, N-2-CBZ-D-tyrosine, N-2-CBZ-D-valine, (R)-2-chlorobutyric acid, 3-chloromandelic acid, 4-chloromandelic acid, 1-((S)-3-chloro-2-methylpropionyl)-1-proline, (R)-2-(4′-chlorophenoxy)-propionic acid, 3-(4′-chlorophenyl)alanine, 2-(4′-chlorophenyl)-3-phenylpropionic acid, chlorophos, 2-chloropropionic acid, (S)-2-chloropropionic acid sodium salt (50% solution), cyclohexylalanine, cyclohexylglycine, cyclophos, D-cysteine, D-cysteine hydrochloride monohydrate, D-cysteine, dibenzoyl-tartaric acid, 1-3-(3′,4′-dichlorophenyl)-alanine, diethyl-1-tartrate, D-1-dihydrophenylglycine, D-1-dihydrophenylglycine chloride hydrochloride, D-(3′,4′-dihydroxy)-1-phenylglycine, diisopropyl-tartrate, dimethyl-tartrate, 2-3-diphenylpropionic acid, di-p-toluoyl-tartaric acid, ethyl-(R)-2-(N-acetylamino)-2,4-dimethylpentanoate, ethyl-(R)-2-(N-acetylamino)-2-methyl-3-phenylpropionate, ethyl-4-bromo-3-hydroxybutyrate, ethyl-4-chloro-3-hydroxybutyrate, ethyl-(S)-2-chloropropionate, ethyl-2-3-dihydroxybutyrate, ethyl-2-3-dihydroxy-3-phenylpropionate, (R)-ethyl-3-hydroxybutyrate, ethyl-2-hydroxy-2-phenylacetate, ethyl-(R)-2-hydroxy-4-phenybutyrate, ethyl-3-hydroxy-3-phenylpropionate, (R)-ethyl-4-iodo-3-hydroxybutyrate, N-(1-phenylethyl)-phtalimide, D-phenylglycine, N,N,N′,N′-tetramethyl-tartaric acid, thiazolidine-4-carboxylic acid, 3-(2-thienyl)-alanine, D-allo-threonine, valine, N-methylglucamine (−), α-methylbenzylamine, cinochonidine (−), ephedrine (−), hydroquinidine (+), N-benzyl-α-methylbenzylamine, brucine (−), strychnine (−), pseudoephedrine (+), qunidine, quinine (−), cinchonine (+), threo 2-amino-1-(p-nitrophenyl)-1,3-propanediol, 2-amino-1-butanol, methylephedrine (−), α-1-naphthylethyl amine, dehydroabietyl amine, 2-amino-1-phenyl-1,3-propanediol, D-alaninamide, 2-amino-1-propanol, 2-aminobutanol, erythro-2-amino-1,2-diphenylethanol, (S)-1-aminoindane, cis-(1S,2R)aminoindan-2-ol, 1-amino-2-(methoxymethyl)-pyrrolidine, 2-amino-3-methyl-1-butanol, 2-amino-3-methyl-1-pentanol-isoleucinol, 2-amino-4-methyl-1-pentanol-leucinol, 2-amino-1-[4′-(methylthio)-phenyl]-1,3-propanediol, 2-amino-1-phenylethanol, 1-amino-2-propanol, 1-aminotetralin and N-propyl derivative, 2-aminotetralin and N-propyl derivative, N-benzyl-3-aminopyrrolidine, benzyl-benzyl amine, benzyl-4-chlorobenzylamine, cis-N-benzyl-2-(hydroxymethyl)cyclohexylamine, N-benzyl-3-hydroxypyrrolidine, N-benzyl-2-methylbenzylamine, N-benzylamine-methylbenzylamine hydrochloride, 2-benzyl-2-methylbenzylamine, 2-benzyl-3′-methylbenzylamine, 2-benzyl-4′-methylbenzylamine, N-benzyl-1-(1′-naphthyl)ethylamine hydrochloride, bis(methoxymethyl)pyrrolidine, bis {1-[1-naphthyl]ethyl}amine hydrochloride, bis(1-phenylethyl)amine hydrochloride, N,N-bis-[1-phenylethyl]phthalamic acid, N-2-BOC-cyclohexylglycine, BOC-isoleucinol, BOC-phenylalaninol, BOC-prolinol, N-butyl-2-amino-2-methyl-3-(3′,4′-dihydroxyphenyl)-propionate, CBZ-1-cyclohexylalaninol, N-2-CBZ-D-3-(1′naphthyl)alaninol, N-2-CBZ-D-3-(2′naphthyl)alaninol, N-1-phenylalaninol, 2-(2′-chlorobenzyl)benzyl-amine, 2-(3′-chlorobenzyl)benzyl-amine, 2-(4′-chlorobenzyl)benzylamine, (S)-cyclohexylalaninol, 1,2-diaminocyclohexane, (S)-2,6-diamino-1-hexanol (1-lysinol), 1,2-diaminopropane, 2,2-dibenzyl-2-hydroxy-1-methylethylamine, N,N-dibenzylphenylalaninol, N-(3,4-dimethoxybenzyl)-1-phenylethylamine, 3,3-dimethyl-2-aminobutane, N,N-dimethyl-1-methylbenzylamine, N,N-dimethyl-2-(1′-naphthyl)ethylamine, N-(3′,4′-dinitrobenzoyl)-2-methylbenzylamine, N-(3′,5′-dibenzoyl)-1-(1-naphthyl)ethylamine, 1,2-diphenyl-1,2-ethanediamine, 2,2-diphenyl-2-hydroxy-1-methylethylamine, N,N′-ditosyl-1,2-diphenyl-1,2-ethanediamine, 2,2-diphenyl-2-hydroxy-1-methylethylamine, N,N′-ditosyl-1,2′-diphenyl-1,2-ethanediamine, diphenylvalinol, diphenylprolinol, ethyl-(R)-2-amino-2-methyl-3(3′,4′-dimethoxyphenyl)propionate, ethyl(R)-2-amino-2-methyl-3-phenylpropionate, 3-hydroxypyrrolidine, 3-hydroxypyrrolidine HCl, isopropyl-2-methylbenzylamine, 1-tert-leucinol, 1-tert-leucinol hydrochloride, 1-methioniol, 5-methoxy-2-aminotetralin, N-propyl-5-methoxy-2-aminotetralin, 6-methoxy-2-aminotetralin and N-propyl-6-methoxy-2-aminotetralin, 7-methoxy-2-aminotetralin and N-propyl, 8-methoxy-2-aminotetralin and N-propyl, (S)-2-(methoxymethyl)pyrrolidine, (S)-2-(methylamino)propiophenone, D-N-methylamphetamine, 2-(4′-methylbenzyl)benzylamine, 2-(4′methylbenzyl)-N′N′-dimethylbenzylamine, 2-(4′-methylbenzyl)-N-hydroxyethyl-benzylamine, 2-methyl-3′-bromobenzylamine, 2-methyl-4′-bromobenzylamine, 2-methyl-4′-bromobenzylamine hydrochloride, 2-methyl-4′-chlorobenzylamine, 2-methyl-2′-methoxybenzylamine, 2-methyl-3′-methoxybenzyl amine, 1-methyl-3′-methoxybenzylamine, 2-methyl-4′-methoxybenzylamine, 2-methyl-4′-methylbenzylamine, N-methyl-2-methylbenzylamine, N-methyl-2-(1′-naphthyl)-ethylamine, 2-methyl-2′-nitrobenzylamine hydrochloride, 2-methyl-4′-nitrobenzylamine hydrochloride, 1-methyl-3-phenylpropylamine, 2-(1′-naphthyl)ethylamine, 2,(2′-naphthyl)ethylamine, phenylalaninol, (R)1-phenyl-3-aminobutane, 2-phenylglycinol, 1-phenylpropylamine, 2-phenyl-1-propylamine, (S)-prolinol, 1-threoninol, N-acetyl-2-phenylglycinol, dinaphthylprolinol, 2-methylpiperazine, piperidinol, quinuclidinol and combinations thereof.  
   
   
       7 . The kit of  claim 1  wherein the solvent is selected from the group consisting of water acetone, 2-butonone, 2-propanol, methanol, ethanol, 1-propanol, acetonitrile, ethyl acetate, 1-butanol, 2-butanol, n-butyl acetate, carbon tetrachloride, chlorobenzene, chloroform, cyclohexane, cyclopentane, o-, m-, p-dichlorobenzene, dimethyl acetamide, dimethyl sulfoxide, dioxane, 2-ethoxyethanol, ethylene dichloride, glyme, heptane, hexadecane, hexane, iso-hexanes, 2-methoxyethanol, methyl t-butyl ether, methyl isoamyl ketone, methyl n-propyl ketone, dichloromethane, N-methylpyrrolidine, nonane, pentane, petroleum ether, propylene carbonate, pyridine, tetrahydrofuran, toluene, benzene, trichloroethylene, 1,1,2-trichlorotrifluoroethane, 2,2,4-trimethylpentane, o-xylene, actal, acetamide, acetophenone, acetylacetone, adiponitrile, allyl acetate, allyl alcohol, anisole, benzenethiol, benzonitrile, benzyl acetate, benzyl alcohol, benzyl benzoate, benzyl chloride, benzyl ethyl ether, bis(2-chloroethyl)ether, bis(2-ethylhexyl acetate), bromobenzene, 1-bromobutane, 2-bromobutane, 1-bromo-2-chloroethane, bromochloromethane, 1-bromodecane, 2-bromo-2-methylproprane, 1-bromonaphthalene, 1-bromopentane, 1-bromopropane, 2-bromopropane, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, butanenitrile, butanethiol, cis & trans 2-butene-1,4-diol, butyl acetate, sec-butyl acetate, tert-butyl benzene, butyl ethyl ether, butyl formate, butyl methyl ketone, butyl stearate, p-tert-butyltoluene, butyl vinyl ether, γ-butyrolactone, 1-chloro-3-methylbutane, 3-(chloromethyl)heptane, 1-chloronaphthalene, 1-chlorooctane, 1-chloropentane, o-, m-, p-chlorotoluene, cineole, o-, m-, p-cresol, cis,trans-crotonyl alcohol, cumene, cyclohexaol, cyclohexanone, cyclohexene, cyclohexylbenzene, cyclopentanone, p-cymene, cis,trans-decahydronaphthalene, decane, 1-decene, diacetone alcohol, dibenzyl ether, 1,2-dibromo-1,1-difluoroetane, 1,2-dibromoethane, dibromofluoromethane, dibromomethane, 1,2-dibromopropane, dibutyl ether, dibutyl maleate, dibutyl phthalate, dibutyl sebacate, dibutyl sulfide, 1,2-dichloropropane, 2,4-dichlorotoluene, 3,4-dichlorotoluene, diethyl carbonate, diethylene glycol, diethylene glycol dibutyl ether, diethylene glycol, diethylene glycol diethyl ether, diethylene glycol dimethyl ether, dimethylene glycol monoethyl ether, diethylene glycol monoethyl ether acetate, diethylene glycol monomethyl ether, diethyl ketone, diethyl malonate, diethyl oxalate, 2,3-diethylpentane, diethylpentane, diethyl sulfide, diiodomethane, diisobutyl ketone, dipentyl ether, diisopropyl ether, diisoprpyl ketone, dimethyl adipate, dimethyl aniline, 2,2-dimethylbutane, 2,3-dimethylbutane, 3,3-dimethyl-1-butanol, 2,3-dimethyl-2-butanol, 3,3-dimethyl-2-butanol, cis,trans-1,2-dimethylcyclohexane, dimethyl disulfide, N,N-dimethylformamide, dimethyl glutarate, 2,2-dimethylheptane, 2,2-dimethylhexane, 2,3-dimethylhexane, 2,4-dimethylhexane, 2,5-dimethylhexane, 3,3-dimethylhexane, 3,4-dimethylhexane, dimethyl maleate, 1,2-dimethylnaphthalene, 1,6-dimethylnaphthalene, 2,2-dimethylpentane, 2,3-dimethylpentane, 2,4-dimethylpentane, 3,3-dimethylpentane, dimethyl phthalate, 2,2-dimethyl-1-propanol, dimethyl succinate, 1,3-dioxolane, dipentene, dipentyl ether, diphenyl ether, dipropyl ether, dodecane, 1-dodecene, 1,2-epoxybutane, ethyl acetoacetate, ethyl acrylate, ethylbenzene, ethyl benzoate, ethyl butanoate, 2-ethyl-1-butanol, ethylbutyl ketone, ethyl trans-cinnamate, ethyl cyanoacetate, ethylcyclohexane, ethylene carbonate, ethylene glycol, ethylene glycol diacetate, ethylene glycol dibutyl ether, ethylene glycol diethyl ether, ethylene glycol dimethyl ether, ethylene glycol ethylether acetate, ethylene glycol monomethyl ether acetate, ethylene glycol monobutyl ether, ethylene glycol monoethylether, ethylene glycol monomethyl ether, 3-ethylhexane, 2-ethyl-1,3-hexanediol, 2-ethyl-1-hexanol, 2-ethylhexyl acetate, ethyl isovalerate, ethyl lactate, 3-ethyl-2-methylpentane, 3-ethyl-3-methylpentane, 3-ethylpentane, ethyl propanoate, fluorobenzene, o-, m-, p-fluorotoluene, formamide, furfuryl alcohol, glycerol, heptane, 1-heptanol, 2-heptanol, 3-heptanol, 1-heptene, cis,trans2-heptene, hexafluorobenzene, hexamethylphosphoric trimide, hexane, hexanenitrile, 1,2,6-hexanetriol, 1-hexanol, 2-hexanol, 3-hexanol, 1-hexene, cis,trans-2-hexene, cis,trans-3-hexene, hexyl acetate, sec-hexyl acetate, hexylene glycol, hexyl methyl ketone, hydraacrylonitrile, iodobenzene, 1-iodobutane, 2-iodobutane, iodoethane, 1-iodo-2-methylpropane, 1-iodopropane, 2-iodopropane, isobutyl acetate, isobutylbenzene, isobutyl formate, isobutyl isobutanoate, isopentyl acetate, isopentyl isopentanoate, isophorone, isopropyl acetate, D & L-limonene, 2,4-lutidine, 2,6-lutidine, mesitylene, mesityl oxide, n-methylacetamide, methyl acetate, methyl acetoacetate, methyl benzoate, 2-methyl-1-butanol, 3-methyl-1-butanol, 2-methyl-2-butanol, 3-methyl-2-butanol, methyl cyanoactate, methylcyclohexane, 1-methylcyclohexanol, cis,trans-2-methylcyclohexanol, cis,trans-3-methylcyclohexanol, cis,trans-4-methylcyclohexanol, methylcyclopentane, N-methylformamide, 2-methylheptane, 3-methylheptane, 4-methylheptane, 2-methylhexane, 3-methylhexane, methyl isobutyl ketone, methyl isopentyl ketone, 1-methylnaphthalene, 2-methyloctane, 3-methyloctane, 4-methyloctane, methyl oleate, 2-methylpentane, 3-methylpentane, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, 4-methyl-2-pentanol, 2-methyl-3-pentanol, 3-methyl-3-pentanol, 4-methyl-4-penten-2-one, methyl pentyl ketone, N-methylpropanamide, 2-methylpropanenitrile, 2-methyl-1-propanol, 2-methyl-2-propanol, methyl propyl ketone, N-methyl-2-pyrrolidone, methyl salicylate, 2-methyl tetrahydrofuran, 2-methylthiophene, 3-methylthiophene, 4-methylvaleronitrile, β-myracene, nitroethane, nitromethane, 1-nitropropane, 2-nitropropane, nonane, 1-nonene, octane, octanenitrile, 1-octanol, 2-octanol, 1-octene, cis,trans-2-octene, pentachloroethane, 1,5-pentanediol, pentanenitrile, 1-pentanol, 2-pentanol, 3-pentanol, pentyl acetate, β-phellandrene, phenetole, 2-picoline, 3-picoline, 4-picoline, α-pinene, β-pinene, 1,2-propanediol, 1,3-propanediol, propanenitrile, propargyl acetate, propargyl alcohol, propyl acetate, propylbenzene, propyl benzoate, propylene carbonate, propyl formate, pseudocumene, styrene, α-terpinene, terpinolene, 1,1,2,2-tetrabromoethane, 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, tetrachloroethylene, tetrachloromethane, tetraethylene glycol, tetraethylsilane, tetrahydrofuran, tetrahydrofurfuryl alcohol, tetrahydronaphthalene, tetrahydropyran, tetrahydrothiophene, 2,2,3,3-tetramethylpentane, 2,2,3,4-tetramethylpentane, 2,2,4,4-tetramethylpentane, 2,3,3,4-tetramethylpentane, tetramethylurea, thiodiethanol, thiophene, toluene, o-, m-, p-toluidine, α-tolylnitrile, triacetin, tribromomethane, tributyl borate, tributyl phosphate, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloroethylene, trichloroethylsilane, trichlorofluoromethane, (trichloromethyl)benzene, trichloromethylsilane, 1,2,3-trichloropropane, 1,1,2-trichlorotrifluoroethane, tri-o-cresyl phosphate, tridecane, 1-tridecene, triethylene glycol, triethyl phosphate, 2,2,2-trifluoroethanol, (trifluoromethyl)benzene, 1,2,3-trimethylbenzene, 2,2,3-trimethylbutane, 2,2,5-trimethylhexane, 2,3,5-trimethylhexane, 2,2,3-trimethylpentane, 2,2,4-trimethylpentane, 2,3,3-, trimethylpentane, 2,3,4-trimethylpentane, trimethyl phosphate, 1-undecene, veratrole, vinyl acetate o-, m-, p-xylene and combinations thereof.  
   
   
       8 . The kit of  claim 6  wherein the solvent is selected from the group consisting of water acetone, 2-butonone, 2-propanol, methanol, ethanol, 1-propanol, acetonitrile, ethyl acetate, 1-butanol, 2-butanol, n-butyl acetate, carbon tetrachloride, chlorobenzene, chloroform, cyclohexane, cyclopentane, o-, m-, p-dichlorobenzene, dimethyl acetamide, dimethyl sulfoxide, dioxane, 2-ethoxyethanol, ethylene dichloride, glyme, heptane, hexadecane, hexane, iso-hexanes, 2-methoxyethanol, methyl t-butyl ether, methyl isoamyl ketone, methyl n-propyl ketone, dichloromethane, N-methylpyrrolidine, nonane, pentane, petroleum ether, propylene carbonate, pyridine, tetrahydrofuran, toluene, benzene, trichloroethylene, 1,1,2-trichlorotrifluoroethane, 2,2,4-trimethylpentane, o-xylene, actal, acetamide, acetophenone, acetylacetone, adiponitrile, allyl acetate, allyl alcohol, anisole, benzenethiol, benzonitrile, benzyl acetate, benzyl alcohol, benzyl benzoate, benzyl chloride, benzyl ethyl ether, bis(2-chloroethyl)ether, bis(2-ethylhexyl acetate), bromobenzene, 1-bromobutane, 2-bromobutane, 1-bromo-2-chloroethane, bromochloromethane, 1-bromodecane, 2-bromo-2-methylproprane, 1-bromonaphthalene, 1-bromopentane, 1-bromopropane, 2-bromopropane, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, butanenitrile, butanethiol, cis & trans 2-butene-1,4-diol, butyl acetate, sec-butyl acetate, tert-butyl benzene, butyl ethyl ether, butyl formate, butyl methyl ketone, butyl stearate, p-tert-butyltoluene, butyl vinyl ether, γ-butyrolactone, 1-chloro-3-methylbutane, 3-(chloromethyl)heptane, 1-chloronaphthalene, 1-chlorooctane, 1-chloropentane, o-, m-, p-chlorotoluene, cineole, o-, m-, p-cresol, cis,trans-crotonyl alcohol, cumene, cyclohexaol, cyclohexanone, cyclohexene, cyclohexylbenzene, cyclopentanone, p-cymene, cis,trans-decahydronaphthalene, decane, 1-decene, diacetone alcohol, dibenzyl ether, 1,2-dibromo-1,1-difluoroetane, 1,2-dibromoethane, dibromofluoromethane, dibromomethane, 1,2-dibromopropane, dibutyl ether, dibutyl maleate, dibutyl phthalate, dibutyl sebacate, dibutyl sulfide, 1,2-dichloropropane, 2,4-dichlorotoluene, 3,4-dichlorotoluene, diethyl carbonate, diethylene glycol, diethylene glycol dibutyl ether, diethylene glycol, diethylene glycol diethyl ether, diethylene glycol dimethyl ether, dimethylene glycol monoethyl ether, diethylene glycol monoethyl ether acetate, diethylene glycol monomethyl ether, diethyl ketone, diethyl malonate, diethyl oxalate, 2,3-diethylpentane, diethylpentane, diethyl sulfide, diiodomethane, diisobutyl ketone, dipentyl ether, diisopropyl ether, diisopropyl ketone, dimethyl adipate, dimethyl aniline, 2,2-dimethylbutane, 2,3-dimethylbutane, 3,3-dimethyl-1-butanol, 2,3-dimethyl-2-butanol, 3,3-dimethyl-2-butanol, cis,trans-1,2-dimethylcyclohexane, dimethyl disulfide, N,N-dimethylformamide, dimethyl glutarate, 2,2-dimethylheptane, 2,2-dimethylhexane, 2,3-dimethylhexane, 2,4-dimethylhexane, 2,5-dimethylhexane, 3,3-dimethylhexane, 3,4-dimethylhexane, dimethyl maleate, 1,2-dimethylnaphthalene, 1,6-dimethylnaphthalene, 2,2-dimethylpentane, 2,3-dimethylpentane, 2,4-dimethylpentane, 3,3-dimethylpentane, dimethyl phthalate, 2,2-dimethyl-1-propanol, dimethyl succinate, 1,3-dioxolane, dipentene, dipentyl ether, diphenyl ether, dipropyl ether, dodecane, 1-dodecene, 1,2-epoxybutane, ethyl acetoacetate, ethyl acrylate, ethylbenzene, ethyl benzoate, ethyl butanoate, 2-ethyl-1-butanol, ethylbutyl ketone, ethyl trans-cinnamate, ethyl cyanoacetate, ethylcyclohexane, ethylene carbonate, ethylene glycol, ethylene glycol diacetate, ethylene glycol dibutyl ether, ethylene glycol diethyl ether, ethylene glycol dimethyl ether, ethylene glycol ethylether acetate, ethylene glycol monomethyl ether acetate, ethylene glycol monobutyl ether, ethylene glycol monoethylether, ethylene glycol monomethyl ether, 3-ethylhexane, 2-ethyl-1,3-hexanediol, 2-ethyl-1-hexanol, 2-ethylhexyl acetate, ethyl isovalerate, ethyl lactate, 3-ethyl-2-methylpentane, 3-ethyl-3-methylpentane, 3-ethylpentane, ethyl propanoate, fluorobenzene, o-, m-, p-fluorotoluene, formamide, furfuryl alcohol, glycerol, heptane, 1-heptanol, 2-heptanol, 3-heptanol, 1-heptene, cis,trans2-heptene, hexafluorobenzene, hexamethylphosphoric trimide, hexane, hexanenitrile, 1,2,6-hexanetriol, 1-hexanol, 2-hexanol, 3-hexanol, 1-hexene, cis,trans-2-hexene, cis,trans-3-hexene, hexyl acetate, sec-hexyl acetate, hexylene glycol, hexyl methyl ketone, hydraacrylonitrile, iodobenzene, 1-iodobutane, 2-iodobutane, iodoethane, 1-iodo-2-methylpropane, 1-iodopropane, 2-iodopropane, isobutyl acetate, isobutylbenzene, isobutyl formate, isobutyl isobutanoate, isopentyl acetate, isopentyl isopentanoate, isophorone, isopropyl acetate, D & L-limonene, 2,4-lutidine, 2,6-lutidine, mesitylene, mesityl oxide, n-methylacetamide, methyl acetate, methyl acetoacetate, methyl benzoate, 2-methyl-1-butanol, 3-methyl-1-butanol, 2-methyl-2-butanol, 3-methyl-2-butanol, methyl cyanoactate, methylcyclohexane, 1-methylcyclohexanol, cis,trans-2-methylcyclohexanol, cis,trans-3-methylcyclohexanol, cis,trans-4-methylcyclohexanol, methylcyclopentane, N-methylformamide, 2-methylheptane, 3-methylheptane, 4-methylheptane, 2-methylhexane, 3-methylhexane, methyl isobutyl ketone, methyl isopentyl ketone, 1-methylnaphthalene, 2-methyloctane, 3-methyloctane, 4-methyloctane, methyl oleate, 2-methylpentane, 3-methylpentane, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, 4-methyl-2-pentanol, 2-methyl-3-pentanol, 3-methyl-3-pentanol, 4-methyl-4-penten-2-one, methyl pentyl ketone, N-methylpropanamide, 2-methylpropanenitrile, 2-methyl-1-propanol, 2-methyl-2-propanol, methyl propyl ketone, N-methyl-2-pyrrolidone, methyl salicylate, 2-methyl tetrahydrofuran, 2-methylthiophene, 3-methylthiophene, 4-methylvaleronitrile, β-myracene, nitroethane, nitromethane, 1-nitropropane, 2-nitropropane, nonane, 1-nonene, octane, octanenitrile, 1-octanol, 2-octanol, 1-octene, cis,trans-2-octene, pentachloroethane, 1,5-pentanediol, pentanenitrile, 1-pentanol, 2-pentanol, 3-pentanol, pentyl acetate, β-phellandrene, phenetole, 2-picoline, 3-picoline, 4-picoline, α-pinene, β-pinene, 1,2-propanediol, 1,3-propanediol, propanenitrile, propargyl acetate, propargyl alcohol, propyl acetate, propylbenzene, propyl benzoate, propylene carbonate, propyl formate, pseudocumene, styrene, α-terpinene, terpinolene, 1,1,2,2-tetrabromoethane, 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, tetrachloroethylene, tetrachloromethane, tetraethylene glycol, tetraethylsilane, tetrahydrofuran, tetrahydrofurfuryl alcohol, tetrahydronaphthalene, tetrahydropyran, tetrahydrothiophene, 2,2,3,3-tetramethylpentane, 2,2,3,4-tetramethylpentane, 2,2,4,4-tetramethylpentane, 2,3,3,4-tetramethylpentane, tetramethylurea, thiodiethanol, thiophene, toluene, o-, m-, p-toluidine, α-tolylnitrile, triacetin, tribromomethane, tributyl borate, tributyl phosphate, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloroethylene, trichloroethylsilane, trichlorofluoromethane, (trichloromethyl)benzene, trichloromethylsilane, 1,2,3-trichloropropane, 1,1,2-trichlorotrifluoroethane, tri-o-cresyl phosphate, tridecane, 1-tridecene, triethylene glycol, triethyl phosphate, 2,2,2-trifluoroethanol, (trifluoromethyl)benzene, 1,2,3-trimethylbenzene, 2,2,3-trimethylbutane, 2,2,5-trimethylhexane, 2,3,5-trimethylhexane, 2,2,3-trimethylpentane, 2,2,4-trimethylpentane, 2,3,3-, trimethylpentane, 2,3,4-trimethylpentane, trimethyl phosphate, 1-undecene, veratrole, vinyl acetate o-, m-, p-xylene and combinations thereof.  
   
   
       9 . A method for the rapid high throughput determination of the optimum solvents and resolving agents and conditions for the crystallization of diasteroisomeric salts to separate enantiomers, which method comprises: 
 A. Obtaining the kit of  claim 1;     B. Adding to each container of the array of  claim 1  a measured amount of racemic organic compound neat.    C. Heating the combination of sub-step B to a solubilization temperature not in excess of 100° C. for less than 15 minutes;    D. Optionally agitating the combination of substep C for between about 5 min. and 24 hr.;    E. Cooling the heated combination of sub-step C;    F. Observing the formation of diastereoisometric crystals visually or by optical means in each container;    G. Separating the formed diastereoisometric salts;    H. Isolating and evaluating the desired isomer; and    I. Selecting the optimal combinations of resolving agent and solvents and resolution conditions.    
   
   
       10 . The method of  claim 9  wherein the contents of each container are spherically agitated in substep D.  
   
   
       11 . The method of  claim 9  wherein agitation in substep D in each tube is obtained by use of a magnetic stirring bar or a shaking platform.  
   
   
       12 . The method of  claim 9  wherein the initial and final pressure and temperature are ambient conditions.  
   
   
       13 . The method of  claim 9  wherein the components in sub-steps C and D are heated to solubilization or to 100° C. and in sub-step E the components are allowed to cool to ambient temperature.  
   
   
       14 . The method of  claim 9  wherein after cooling the heated combination of sub-step F the temperature is at or lower than 20° C.  
   
   
       15 . The method of  claim 13  wherein the cooled combination is optionally cooled to 4° C. and then to 0° C.  
   
   
       16 . The method of  claim 9  wherein the resolution process described is repeated at least one time.  
   
   
       17 . The method of  claim 9  wherein the solvent in the kit in sub-step A is selected from the group consisting of 90% acetone, methyl ethyl ketone (2-butanone), i-butanol, 2-propanol, 90% 2-propanol, methanol, 80% methanol, ethanol, 96% ethanol, water, 1-propanol, 85% 1-propanol, acetonitrile, ethyl acetate, dichloromethane, chloroform, p-dioxane, methyl-t-butyl ether, toluene and tetrahydrofuran.  
   
   
       18 . The method of  claim 9  wherein the resolving agent, acid or base, in the kit in sub-step A is selected from the group consisting of tartaric acid, pyroglutamic acid, di-p-tolulo-tartaric acid, mandelic acid, malic acid, camphorsulphonic acid, dibenzoyl-tartaric acid, deoxycholic acid (+), camphoric acid (+), quinic acid (−), aspartic acid (+), glutamic acid, 1,3,4,6-diisopropylidine-2-ketogluconic acid (−), acetylmandelic acid, N-acetyl-1-hydroxyproline, N-acetyl-1-leucine, acetyl-3-mercapto-2-methylpropionic acid, 3-acetylmercapto-2-methylpropionyl-1-proline, N-acetyl-D-3-(2-naphthyl)-alanine, (R)-acetylthio-2-methylpropionyl chloride, N-acetyl-1-phenylalanine, N-acetyl-1-tyrosinamide, D-alanine, 1-aminoadipic acid, (R)-2-aminobutyric acid, (1R,4S)-4-aminocyclopent-2-ene-1-carboxylic acid, (1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid, S-2-amino-3,3-dimethylbutyric acid, 1-tert-leucine, 1,2-amino-2-methyl-3-(3′,4′-dimethoxyphenyl)-propionitrile HCl, 1-2-amino-2-methyl-3-(3′,4′-dihydroxyphenyl)-propionic acid, (R)-2-amino-4-phenylbutane, D-arginine, D-aspartic acid, D-2-azidophenylacetic acid, D-2-azidophenylacetyl chloride, (1S,2R)-cis-2-benzamido-cyclohexane-carboxylic acid, (1R,2S)-cis-2-benzamido-cyclohexane-carboxylic acid, benzyl-(R) & (S)-mandelate, benzyl-2-tosyloxypropionate, N-2-BOC-D-alanine, N-2-BOC-1-aminoadipic acid, 3-(R)—BOC-aminocyclopent-4-ene-1-(S)-carboxylic acid, 3-(S)—BOC-aminocyclopent-4-ene-1-(R)-carboxylic acid, N-2-BOC-D-arginine hydrochloride, N-2-BOC-D-aspartic acid, N-2-BOC-3-(4-bipheny)alanine, N-2-BOC—N-6-CBZ-D-lysine, N-2-BOC-3-(4-chlorophenyl)-alanine, N-2-BOC-cyclohexylalanine, N-2-BOC-1-cyclohexylalanine methyl ester, N-2-BOC-3,3-diphenylalanine, N-2-BOC-3-(4-fluorophenyl)-alanine, N-2-BOC-D-glutamic acid 1-benzyl ester, N-2-BOC-D-histidine, N-2-BOC-3-(4-iodophenyl)-alanine, N-3-BOC-D-leucine, N-3-BOC-1-tert-leucine DCHA salt, (1S)-camphanic acid, (1R)-camphorsulfonic acid, (1S)-camphorsulfonic acid, 2-methylbenzylamine, N-2-BOC-D-methionine, N-2-BOC-3-(1′-naphtyl)alanine, N-2-BOC-3-(2′-naphtyl)alanine, N-2-BOC-3-(4′-nitrophenyl)alanine, N-2-BOC-1-octahydroindole-2-carboxylic acid, N-2-BOC-3-(pentafluorophenyl)-alanine, N-2-BOC-D-phenylalanine, N—BOC-D-proline, N-1-BOC-D-3-(2′-pyridyl)alanine, N-2-BOC-1-3-(2′-pyridyl)alanine, N-2-BOC-D-3-(3-pyridyl)alanine, N-1-BOC-1-3-(3′-pyridyl)alanine, N-2-BOC-D-serine, N—BOC-1,2,3,4-tetrahydroisoquinoline-(3R)-carboxylic acid, N—BOC-1,2,3,4-tetrahydroisoquinoline-(3S)-carboxylic acid, N-2-BOC-3-(4′-thiazolyl)alanine, N—BOC-D-threonine, N-2-BOC—N-8-tosyl-D-arginine, N-2-BOC-D-tryptophan, N-2-BOC-D-tyrosine, N-2-BOC-D-tyrosine methyl ester, N-2-BOC-D-valine, 2-bromobutyric acid, 2-bromohexadecanoic acid, (R)-2-bromo-2-phenylacetic acid, 2-bromopropionic acid, butyl-(S)-2-chloropropionate, (2R,3S)-butyl-2,3-epoxybutyrate, (R)-butyl-2,3-epoxybutyrate, (S)-tert-butyl-3-hydroxybutyrate, (S)-butyl-lactate, N-butyl-(R)-2-methyl-2-hydrazino-3-(3′-methoxy-4′-hydroxyphenyl)-propionate, N—CBZ-D-alanine, N—CBZ-D-arginine, N—CBZ-D-aspartic acid, N—CBZ-O-tert-butyl-D-serine, CBZ-1-cyclohexylalanine, N—CBZ-D-glutamic acid, N—CBZ-D-histidine, N—CBZ-D-leucine, N—CBZ-1-tert-leucine DCHA salt, N—CBZ-D-methionine, N-2-CBZ-D-3-(2′-naphthyl)alanine, N-2-CBZ-ornithine, N-2-CBZ-D-phenylalanine, N-2-CBZ-D-proline, N-2-CBZ-D-serine, N-2-CBZ-D-threonine, N-2-CBZ-D-tryptophan, N-2-CBZ-D-tyrosine, N-2-CBZ-D-valine, (R)-2-chlorobutyric acid, 3-chloromandelic acid, 4-chloromandelic acid, 1-((S)-3-chloro-2-methylpropionyl)-1-proline, (R)-2-(4′-chlorophenoxy)-propionic acid, 3-(4′-chlorophenyl)alanine, 2-(4′-chlorophenyl)-3-phenylpropionic acid, chlorophos, 2-chloropropionic acid, (S)-2-chloropropionic acid sodium salt (50% solution), cyclohexylalanine, cyclohexylglycine, cyclophos, D-cysteine, D-cysteine hydrochloride monohydrate, D-cysteine, dibenzoyl-tartaric acid, 1-3-(3′,4′-dichlorophenyl)-alanine, diethyl-1-tartrate, D-1-dihydrophenylglycine, D-1-dihydrophenylglycine chloride hydrochloride, D-(3′,4′-dihydroxy)-1-phenylglycine, diisopropyl-tartrate, dimethyl-tartrate, 2-3-diphenylpropionic acid, di-p-toluoyl-tartaric acid, ethyl-(R)-2-(N-acetylamino)-2,4-dimethylpentanoate, ethyl-(R)-2-(N-acetylamino)-2-methyl-3-phenylpropionate, ethyl-4-bromo-3-hydroxybutyrate, ethyl-4-chloro-3-hydroxybutyrate, ethyl-(S)-2-chloropropionate, ethyl-2-3-dihydroxybutyrate, ethyl-2-3-dihydroxy-3-phenylpropionate, (R)-ethyl-3-hydroxybutyrate, ethyl-2-hydroxy-2-phenylacetate, ethyl-(R)-2-hydroxy-4-phenybutyrate, ethyl-3-hydroxy-3-phenylpropionate, (R)-ethyl-4-iodo-3-hydroxybutyrate, N-(1-phenylethyl)-phtalimide, D-phenylglycine, N,N,N′,N′-tetramethyl-tartaric acid, thiazolidine-4-carboxylic acid, 3-(2-thienyl)-alanine, D-allo-threonine, valine, N-methylglucamine (−), α-methylbenzylamine, cinochonidine (−), ephedrine (−), hydroquinidine (+), N-benzyl-α-methylbenzylamine, brucine (−), strychnine (−), pseudoephedrine (+), qunidine, quinine (−), cinchonine (+), threo 2-amino-1-(p-nitrophenyl)-1,3-propanediol, 2-amino-1-butanol, methylephedrine (−), α-1-naphthylethyl amine, dehydroabietyl amine, 2-amino-1-phenyl-1,3-propanediol, D-alaninamide, 2-amino-1-propanol, 2-aminobutanol, erythro-2-amino-1,2-diphenylethanol, (S)-1-aminoindane, cis-(1S,2R)aminoindan-2-ol, 1-amino-2-(methoxymethyl)-pyrrolidine, 2-amino-3-methyl-1-butanol, 2-amino-3-methyl-1-pentanol-isoleucinol, 2-amino-4-methyl-1-pentanol-leucinol, 2-amino-1-[4′-(methylthio)-phenyl]-1,3-propanediol, 2-amino-1-phenylethanol, 1-amino-2-propanol, 1-aminotetralin and N-propyl derivative, 2-aminotetralin and N-propyl derivative, N-benzyl-3-aminopyrrolidine, benzyl-benzyl amine, benzyl-4-chlorobenzylamine, cis-N-benzyl-2-(hydroxymethyl)cyclohexylamine, N-benzyl-3-hydroxypyrrolidine, N-benzyl-2-methylbenzylamine, N-benzylamine-methylbenzylamine hydrochloride, 2-benzyl-2-methylbenzylamine, 2-benzyl-3′-methylbenzylamine, 2-benzyl-4′-methylbenzylamine, N-benzyl-1-(1′-naphthyl)ethylamine hydrochloride, bis(methoxymethyl)pyrrolidine, bis {1-[1-naphthyl]ethyl}amine hydrochloride, bis(1-phenylethyl)amine hydrochloride, N,N-bis-[1-phenylethyl]phthalamic acid, N-2-BOC-cyclohexylglycine, BOC-isoleucinol, BOC-phenylalaninol, BOC-prolinol, N-butyl-2-amino-2-methyl-3-(3′,4′-dihydroxyphenyl)-propionate, CBZ-1-cyclohexylalaninol, N-2-CBZ-D-3-(1′naphthyl)alaninol, N-2-CBZ-D-3-(2′naphthyl)alaninol, N-1-phenylalaninol, 2-(2′-chlorobenzyl)benzyl-amine, 2-(3′-chlorobenzyl)benzyl-amine, 2-(4′-chlorobenzyl)benzylamine, (S)-cyclohexylalaninol, 1,2-diaminocyclohexane, (S)-2,6-diamino-1-hexanol (1-lysinol), 1,2-diaminopropane, 2,2-dibenzyl-2-hydroxy-1-methylethylamine, N,N-dibenzylphenylalaninol, N-(3,4-dimethoxybenzyl)-1-phenylethylamine, 3,3-dimethyl-2-aminobutane, N,N-dimethyl-1-methylbenzylamine, N,N-dimethyl-2-(1′-naphthyl)ethylamine, N-(3′,4′-dinitrobenzoyl)-2-methylbenzylamine, N-(3′,5′-dibenzoyl)-1-(1-naphthyl)ethylamine, 1,2-diphenyl-1,2-ethanediamine, 2,2-diphenyl-2-hydroxy-1-methylethylamine, N,N′-ditosyl-1,2-diphenyl-1,2-ethanediamine, 2,2-diphenyl-2-hydroxy-1-methylethylamine, N,N′-ditosyl-1,2′-diphenyl-1,2-ethanediamine, diphenylvalinol, diphenylprolinol, ethyl-(R)-2-amino-2-methyl-3(3′,4′-dimethoxyphenyl)propionate, ethyl(R)-2-amino-2-methyl-3-phenylpropionate, 3-hydroxypyrrolidine, 3-hydroxypyrrolidine HCl, isopropyl-2-methylbenzylamine, 1-tert-leucinol, 1-tert-leucinol hydrochloride, 1-methioniol, 5-methoxy-2-aminotetralin, N-propyl-5-methoxy-2-aminotetralin, 6-methoxy-2-aminotetralin and N-propyl-6-methoxy-2-aminotetralin, 7-methoxy-2-aminotetralin and N-propyl, 8-methoxy-2-aminotetralin and N-propyl, (S)-2-(methoxymethyl)pyrrolidine, (S)-2-(methylamino)propiophenone, D-N-methylamphetamine, 2-(4′-methylbenzyl)benzylamine, 2-(4′methylbenzyl)-N′N′-dimethylbenzylamine, 2-(4′-methylbenzyl)-N-hydroxyethyl-benzylamine, 2-methyl-3′-bromobenzylamine, 2-methyl-4′-bromobenzylamine, 2-methyl-4′-bromobenzylamine hydrochloride, 2-methyl-4′-chlorobenzylamine, 2-methyl-2′-methoxybenzylamine, 2-methyl-3′-methoxybenzylamine, 1-methyl-3′-methoxybenzylamine, 2-methyl-4′-methoxybenzylamine, 2-methyl-4′-methylbenzylamine, N-methyl-2-methylbenzylamine, N-methyl-2-(1′-naphthyl)-ethylamine, 2-methyl-2′-nitrobenzylamine hydrochloride, 2-methyl-4′-nitrobenzylamine hydrochloride, 1-methyl-3-phenylpropylamine, 2-(1′-naphthyl)ethylamine, 2,(2′-naphthyl)ethylamine, phenylalaninol, (R)1-phenyl-3-aminobutane, 2-phenylglycinol, 1-phenylpropylamine, 2-phenyl-1-propylamine, (S)-prolinol, 1-threoninol, N-acetyl-2-phenylglycinol, dinaphthylprolinol, 2-methylpiperazine, piperidinol, quinuclidinol and combinations thereof.  
   
   
       19 . The method of  claim 9  wherein the solvent is selected from the group consisting of water acetone, 2-butonone, 2-propanol, methanol, ethanol, 1-propanol, acetonitrile, ethyl acetate, 1-butanol, 2-butanol, n-butyl acetate, carbon tetrachloride, chlorobenzene, chloroform, cyclohexane, cyclopentane, o-, m-, p-dichlorobenzene, dimethyl acetamide, dimethyl sulfoxide, dioxane, 2-ethoxyethanol, ethylene dichloride, glyme, heptane, hexadecane, hexane, iso-hexanes, 2-methoxyethanol, methyl t-butyl ether, methyl isoamyl ketone, methyl n-propyl ketone, dichloromethane, N-methylpyrrolidine, nonane, pentane, petroleum ether, propylene carbonate, pyridine, tetrahydrofuran, toluene, benzene, trichloroethylene, 1,1,2-trichlorotrifluoroethane, 2,2,4-trimethylpentane, o-xylene, actal, acetamide, acetophenone, acetylacetone, adiponitrile, allyl acetate, allyl alcohol, anisole, benzenethiol, benzonitrile, benzyl acetate, benzyl alcohol, benzyl benzoate, benzyl chloride, benzyl ethyl ether, bis(2-chloroethyl)ether, bis(2-ethylhexyl acetate), bromobenzene, 1-bromobutane, 2-bromobutane, 1-bromo-2-chloroethane, bromochloromethane, 1-bromodecane, 2-bromo-2-methylproprane, 1-bromonaphthalene, 1-bromopentane, 1-bromopropane, 2-bromopropane, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, butanenitrile, butanethiol, cis & trans 2-butene-1,4-diol, butyl acetate, sec-butyl acetate, tert-butyl benzene, butyl ethyl ether, butyl formate, butyl methyl ketone, butyl stearate, p-tert-butyltoluene, butyl vinyl ether, γ-butyrolactone, 1-chloro-3-methylbutane, 3-(chloromethyl)heptane, 1-chloronaphthalene, 1-chlorooctane, 1-chloropentane, o-, m-, p-chlorotoluene, cineole, o-, m-, p-cresol, cis,trans-crotonyl alcohol, cumene, cyclohexaol, cyclohexanone, cyclohexene, cyclohexylbenzene, cyclopentanone, p-cymene, cis,trans-decahydronaphthalene, decane, 1-decene, diacetone alcohol, dibenzyl ether, 1,2-dibromo-1,1-difluoroetane, 1,2-dibromoethane, dibromofluoromethane, dibromomethane, 1,2-dibromopropane, dibutyl ether, dibutyl maleate, dibutyl phthalate, dibutyl sebacate, dibutyl sulfide, 1,2-dichloropropane, 2,4-dichlorotoluene, 3,4-dichlorotoluene, diethyl carbonate, diethylene glycol, diethylene glycol dibutyl ether, diethylene glycol, diethylene glycol diethyl ether, diethylene glycol dimethyl ether, dimethylene glycol monoethyl ether, diethylene glycol monoethyl ether acetate, diethylene glycol monomethyl ether, diethyl ketone, diethyl malonate, diethyl oxalate, 2,3-diethylpentane, diethylpentane, diethyl sulfide, diiodomethane, diisobutyl ketone, dipentyl ether, diisopropyl ether, diisoprpyl ketone, dimethyl adipate, dimethyl aniline, 2,2-dimethylbutane, 2,3-dimethylbutane, 3,3-dimethyl-1-butanol, 2,3-dimethyl-2-butanol, 3,3-dimethyl-2-butanol, cis,trans-1,2-dimethylcyclohexane, dimethyl disulfide, N,N-dimethylformamide, dimethyl glutarate, 2,2-dimethylheptane, 2,2-dimethylhexane, 2,3-dimethylhexane, 2,4-dimethylhexane, 2,5-dimethylhexane, 3,3-dimethylhexane, 3,4-dimethylhexane, dimethyl maleate, 1,2-dimethylnaphthalene, 1,6-dimethylnaphthalene, 2,2-dimethylpentane, 2,3-dimethylpentane, 2,4-dimethylpentane, 3,3-dimethylpentane, dimethyl phthalate, 2,2-dimethyl-1-propanol, dimethyl succinate, 1,3-dioxolane, dipentene, dipentyl ether, diphenyl ether, dipropyl ether, dodecane, 1-dodecene, 1,2-epoxybutane, ethyl acetoacetate, ethyl acrylate, ethylbenzene, ethyl benzoate, ethyl butanoate, 2-ethyl-1-butanol, ethylbutyl ketone, ethyl trans-cinnamate, ethyl cyanoacetate, ethylcyclohexane, ethylene carbonate, ethylene glycol, ethylene glycol diacetate, ethylene glycol dibutyl ether, ethylene glycol diethyl ether, ethylene glycol dimethyl ether, ethylene glycol ethylether acetate, ethylene glycol monomethyl ether acetate, ethylene glycol monobutyl ether, ethylene glycol monoethylether, ethylene glycol monomethyl ether, 3-ethylhexane, 2-ethyl-1,3-hexanediol, 2-ethyl-1-hexanol, 2-ethylhexyl acetate, ethyl isovalerate, ethyl lactate, 3-ethyl-2-methylpentane, 3-ethyl-3-methylpentane, 3-ethylpentane, ethyl propanoate, fluorobenzene, o-, m-, p-fluorotoluene, formamide, furfuryl alcohol, glycerol, heptane, 1-heptanol, 2-heptanol, 3-heptanol, 1-heptene, cis,trans2-heptene, hexafluorobenzene, hexamethylphosphoric trimide, hexane, hexanenitrile, 1,2,6-hexanetriol, 1-hexanol, 2-hexanol, 3-hexanol, 1-hexene, cis,trans-2-hexene, cis,trans-3-hexene, hexyl acetate, sec-hexyl acetate, hexylene glycol, hexyl methyl ketone, hydraacrylonitrile, iodobenzene, 1-iodobutane, 2-iodobutane, iodoethane, 1-iodo-2-methylpropane, 1-iodopropane, 2-iodopropane, isobutyl acetate, isobutylbenzene, isobutyl formate, isobutyl isobutanoate, isopentyl acetate, isopentyl isopentanoate, isophorone, isopropyl acetate, D & L-limonene, 2,4-lutidine, 2,6-lutidine, mesitylene, mesityl oxide, n-methylacetamide, methyl acetate, methyl acetoacetate, methyl benzoate, 2-methyl-1-butanol, 3-methyl-1-butanol, 2-methyl-2-butanol, 3-methyl-2-butanol, methyl cyanoactate, methylcyclohexane, 1-methylcyclohexanol, cis,trans-2-methylcyclohexanol, cis,trans-3-methylcyclohexanol, cis,trans-4-methylcyclohexanol, methylcyclopentane, N-methylformamide, 2-methylheptane, 3-methylheptane, 4-methylheptane, 2-methylhexane, 3-methylhexane, methyl isobutyl ketone, methyl isopentyl ketone, 1-methylnaphthalene, 2-methyloctane, 3-methyloctane, 4-methyloctane, methyl oleate, 2-methylpentane, 3-methylpentane, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, 4-methyl-2-pentanol, 2-methyl-3-pentanol, 3-methyl-3-pentanol, 4-methyl-4-penten-2-one, methyl pentyl ketone, N-methylpropanamide, 2-methylpropanenitrile, 2-methyl-1-propanol, 2-methyl-2-propanol, methyl propyl ketone, N-methyl-2-pyrrolidone, methyl salicylate, 2-methyl tetrahydrofuran, 2-methylthiophene, 3-methylthiophene, 4-methylvaleronitrile, β-myracene, nitroethane, nitromethane, 1-nitropropane, 2-nitropropane, nonane, 1-nonene, octane, octanenitrile, 1-octanol, 2-octanol, 1-octene, cis,trans-2-octene, pentachloroethane, 1,5-pentanediol, pentanenitrile, 1-pentanol, 2-pentanol, 3-pentanol, pentyl acetate, 0-phellandrene, phenetole, 2-picoline, 3-picoline, 4-picoline, α-pinene, ⊖-pinene, 1,2-propanediol, 1,3-propanediol, propanenitrile, propargyl acetate, propargyl alcohol, propyl acetate, propylbenzene, propyl benzoate, propylene carbonate, propyl formate, pseudocumene, styrene, α-terpinene, terpinolene, 1,1,2,2-tetrabromoethane, 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, tetrachloroethylene, tetrachloromethane, tetraethylene glycol, tetraethylsilane, tetrahydrofuran, tetrahydrofurfuryl alcohol, tetrahydronaphthalene, tetrahydropyran, tetrahydrothiophene, 2,2,3,3-tetramethylpentane, 2,2,3,4-tetramethylpentane, 2,2,4,4-tetramethylpentane, 2,3,3,4-tetramethylpentane, tetramethylurea, thiodiethanol, thiophene, toluene, o-, m-, p-toluidine, α-tolylnitrile, triacetin, tribromomethane, tributyl borate, tributyl phosphate, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloroethylene, trichloroethylsilane, trichlorofluoromethane, (trichloromethyl)benzene, trichloromethylsilane, 1,2,3-trichloropropane, 1,1,2-trichlorotrifluoroethane, tri-o-cresyl phosphate, tridecane, 1-tridecene, triethylene glycol, triethyl phosphate, 2,2,2-trifluoroethanol, (trifluoromethyl)benzene, 1,2,3-trimethylbenzene, 2,2,3-trimethylbutane, 2,2,5-trimethylhexane, 2,3,5-trimethylhexane, 2,2,3-trimethylpentane, 2,2,4-trimethylpentane, 2,3,3-, trimethylpentane, 2,3,4-trimethylpentane, trimethyl phosphate, 1-undecene, veratrole, vinyl acetate o-, m-, p-xylene and combinations thereof.  
   
   
       20 . The method of  claim 19  wherein the resolving agent in the kit in sub-step A is selected from the group consisting of tartaric acid, pyroglutamic acid, di-p-tolulo-tartaric acid, mandelic acid, malic acid, camphorsulphonic acid, dibenzoyl-tartaric acid, deoxycholic acid (+), camphoric acid (+), quinic acid (−), aspartic acid (+), glutamic acid, 1,3,4,6-diisopropylidine-2-ketogluconic acid (−), acetylmandelic acid, N-acetyl-1-hydroxyproline, N-acetyl-1-leucine, acetyl-3-mercapto-2-methylpropionic acid, 3-acetylmercapto-2-methylpropionyl-1-proline, N-acetyl-D-3-(2-naphthyl)-alanine, (R)-acetylthio-2-methylpropionyl chloride, N-acetyl-1-phenylalanine, N-acetyl-1-tyrosinamide, D-alanine, 1-aminoadipic acid, (R)-2-aminobutyric acid, (1R,4S)-4-aminocyclopent-2-ene-1-carboxylic acid, (1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid, S-2-amino-3,3-dimethylbutyric acid, 1-tert-leucine, 1,2-amino-2-methyl-3-(3′,4′-dimethoxyphenyl)-propionitrile HCl, 1-2-amino-2-methyl-3-(3′,4′-dihydroxyphenyl)-propionic acid, (R)-2-amino-4-phenylbutane, D-argine, D-aspartic acid, D-2-azidophenylacetic acid, D-2-azidophenylacetyl chloride, (1S,2R)-cis-2-benzamido-cyclohexane-carboxylic acid, (1R,2S)-cis-2-benzamido-cyclohexane-carboxylic acid, benzyl-(R) & (S)-mandelate, benzyl-2-tosyloxypropionate, N-2-BOC-D-alanine, N-2-BOC-1-aminoadipic acid, 3-(R)—BOC-aminocyclopent-4-ene-1-(S)-carboxylic acid, 3-(S)—BOC-aminocyclopent-4-ene-1-(R)-carboxylic acid, N-2-BOC-D-arginine hydrochloride, N-2-BOC-D-aspartic acid, N-2-BOC-3-(4-bipheny)alanine, N-2-BOC—N-6-CBZ-D-lysine, N-2-BOC-3-(4-chlorophenyl)-alanine, N-2-BOC-cyclohexylalanine, N-2-BOC-1-cyclohexylalanine methyl ester, N-2-BOC-3,3-diphenylalanine, N-2-BOC-3-(4-fluorophenyl)-alanine, N-2-BOC-D-glutamic acid 1-benzyl ester, N-2-BOC-D-histidine, N-2-BOC-3-(4-iodophenyl)-alanine, N-3-BOC-D-leucine, N-3-BOC-1-tert-leucine DCHA salt, (1S)-camphanic acid, (1R)-camphorsulfonic acid, (1S)-camphorsulfonic acid, 2-methylbenzylamine, N-2-BOC-D-methionine, N-2-BOC-3-(1′-Naphtyl)alanine, N-2-BOC-3-(2′-naphtyl)alanine, N-2-BOC-3-(4′-nitrophenyl)alanine, N-2-BOC-1-octahydroindole-2-carboxylic acid, N-2-BOC-3-(pentafluorophenyl)-alanine, N-2-BOC-D-phenylalanine, N—BOC-D-proline, N-1-BOC-D-3-(2′-pyridyl)alanine, N-2-BOC-1-3-(2′-pyridyl)alanine, N-2-BOC-D-3-(3-pyridyl)alanine, N-1-BOC-1-3-(3′-pyridyl)alanine, N-2-BOC-D-serine, N—BOC-1,2,3,4-tetrahydroisoquinoline-(3R)-carboxylic acid, N—BOC-1,2,3,4-tetrahydroisoquinoline-(3S)-carboxylic acid, N-2-BOC-3-(4′-thiazolyl)alanine, N—BOC-D-threonine, N-2-BOC—N-8-tosyl-D-arginine, N-2-BOC-D-tryptophan, N-2-BOC-D-tyrosine, N-2-BOC-D-tyrosine methyl ester, N-2-BOC-D-valine, 2-bromobutyric acid, 2-bromohexadecanoic acid, (R)-2-bromo-2-phenylacetic acid, 2-bromopropionic acid, butyl-(S)-2-chloropropionate, (2r,3S)-butyl-2,3-epoxybutyrate, (R)-butyl-2,3-epoxybutyrate, (S)-tert-butyl-3-hydroxybutyrate, (S)-butyl-lactate, N-butyl-(R)-2-methyl-2-hydrazino-3-(3′-methoxy-4′-hydroxyphenyl)-propionate, N—CBZ-D-alanine, N—CBZ-D-arginine, N—CBZ-D-aspartic acid, N—CBZ-D-tert-butyl-D-serine, CBZ-1-cyclohexylalanine, N—CBZ-D-glutamic acid, N—CBZ-D-histidine, N—CBZ-D-leucine, N—CBZ-1-tert-leucine DCHA salt, N—CBZ-D-methionine, N-2-CBZ-D-3-(2′-naphthyl)alanine, N-2-CBZ-ornithine, N-2-CBZ-D-phenylalanine, N-2-CBZ-D-proline, N-2-CBZ-D-serine, N-2-CBZ-D-threonine, N-2-CBZ-D-tryptophan, N-2-CBZ-D-tyrosine, N-2-CBZ-D-valine, (R)-2-chlorobutyric acid, 3-chloromandelic acid, 4-chloromandelic acid, 1-((S)-3-chloro-2-methylpropionyl)-1-proline, (R)-2-(4′-chlorophenoxy)-propionic acid, 3-(4′-chlorophenyl)alanine, 2-(4′-chlorophenyl)-3-phenylpropionic acid, chlorophos, 2-chloropropionic acid, (S)-2-chloropropionic acid sodium salt (50% solution), cyclohexylalanine, cyclohexylglycine, cyclophos, D-cysteine, D-cysteine hydrochloride monohydrate, D-cysteine, dibenzoyl-tartaric acid, 1-3-(3′,4′-dichlorophenyl)-alanine, diethyl-1-tartrate, D-1-dihydrophenylglycine, D-1-dihydrophenylglycine chloride hydrochloride, D-(3′,4′-dihydroxy)-1-phenylglycine, diisopropyl-tartrate, dimethyl-tartrate, 2-3-diphenylpropionic acid, di-p-toluoyl-tartaric acid, ethyl-(R)-2-(N-acetylamino)-2,4-dimethylpentanoate, ethyl-(R)-2-(N-acetylamino)-2-methyl-3-phenylpropionate, ethyl-4-bromo-3-hydroxybutyrate, ethyl-4-chloro-3-hydroxybutyrate, ethyl-(S)-2-chloropropionate, ethyl-2-3-dihydroxybutyrate, ethyl-2-3-dihydroxy-3-phenylpropionate, (R)-ethyl-3-hydroxybutyrate, ethyl-2-hydroxy-2-phenylacetate, ethyl-(R)-2-hydroxy-4-phenybutyrate, ethyl-3-hydroxy-3-phenylpropionate, (R)-ethyl-4-iodo-3-hydroxybutyrate, N-(1-phenylethyl)-phtalimide, D-phenylglycine, N,N,N′,N′-tetramethyl-tartaric acid, thiazolidine-4-carboxylic acid, 3-(2-thienyl)-alanine, D-allo-threonine, valine, N-methylglucamine (−), α-methylbenzylamine, cinochonidine (−), ephedrine (−), hydroquinidine (+), n-benzyl-α-methylbenzylamine, brucine (−), strychnine (−), pseudoephedrine (+), qunidine, quinine (−), cinchonine (+), threo 2-amino-1-(p-nitrophenyl)-1,3-propanediol, 2-amino-1-butanol, methylephedrine (−), α-1-naphthylethyl amine, dehydroabietyl amine, 2-amino-1-phenyl-1,3-propanediol, D-alaninamide, 2-amino-1-propanol, 2-aminobutanol, erythro-2-amino-1,2-diphenylethanol, (S)-1-aminoindane, cis-(1S,2R)aminoindaN-2-ol, 1-amino-2-(methoxymethyl)-pyrrolidine, 2-amino-3-methyl-1-butanol, 2-amino-3-methyl-1-pentanol-isoleucinol, 2-amino-4-methyl-1-pentanol-leucinol, 2-amino-1-[4′-(methylthio)-phenyl]-1,3-propanediol, 2-amino-1-phenylethanol, 1-amino-2-propanol, 1-aminotetralin and N-propyl derivative, 2-aminotetralin and N-propyl derivative, N-benzyl-3-aminopyrrolidine, benzyl-benzyl amine, benzyl-4-chlorobenzylamine, cis-N-benzyl-2-(hydroxymethyl)cyclohexylamine, N-benzyl-3-hydroxypyrrolidine, N-benzyl-2-methylbenzylamine, N-benzylamine-methylbenzylamine hydrochloride, 2-benzyl-2-methylbenzylamine, 2-benzyl-3′-methylbenzylamine, 2-benzyl-4′-methylbenzylamine, N-benzyl-1-(1′-naphthyl)ethylamine hydrochloride, Bis(methoxymethyl)pyrrolidine, Bis {1-[1-naphthyl]ethyl}amine hydrochloride, Bis(1-phenylethyl)amine hydrochloride, N,N-bis-[1-phenylethyl]phthalamic acid, N-2-BOC-cyclohexylglycine, BOC-isoleucinol, BOC-phenylalaninol, BOC-prolinol, N-butyl-2-amino-2-methyl-3-(3′,4′-dihydroxyphenyl)-propionate, CBZ-1-cyclohexylalaninol, N-2-CBZ-D-3-(1′naphthyl)alaninol, N-2-CBZ-D-3-(2′naphthyl)alaninol, N-1-phenylalaninol, 2-(2′-chlorobenzyl)benzyl-amine, 2-(3′-chlorobenzyl)benzyl-amine, 2-(4′-chlorobenzyl)benzylamine, (S)-cyclohexylalaninol, 1,2-diaminocyclohexane, (S)-2,6-diamino-1-hexanol (1-lysinol), 1,2-diaminopropane, 2,2-dibenzyl-2-hydroxy-1-methylethylamine, N,N-dibenzylphenylalaninol, N-(3,4-dimethoxybenzyl)-1-phenylethylamine, 3,3-dimethyl-2-aminobutane, N,N-dimethyl-1-methylbenzylamine, N,N-dimethyl-2-(1′-naphthyl)ethylamine, N-(3′,4′-dinitrobenzoyl)-2-methylbenzylamine, N-(3′,5′-dibenzoyl)-1-(1-naphthyl)ethylamine, 1,2-diphenyl-1,2-ethanediamine, 2,2-diphenyl-2-hydroxy-1-methylethylamine, N,N′-ditosyl-1,2-diphenyl-1,2-ethanediamine, 2,2-diphenyl-2-hydroxy-1-methylethylamine, N,N′-ditosyl-1,2′-diphenyl-1,2-ethanediamine, diphenylvalinol, diphenylprolinol, ethyl-(R)-2-amino-2-methyl-3(3′,4′-dimethoxyphenyl)propionate, ethyl(R)-2-amino-2-methyl-3-phenylpropionate, 3-hydroxypyrrolidine, 3-hydroxypyrrolidine HCl, isopropyl-2-methylbenzylamine, 1-tert-leucinol, 1-tert-leucinol hydrochloride, 1-methioniol, 5-methoxy-2-aminotetralin, N-propyl-5-methoxy-2-aminotetralin derivative, 6-methoxy-2-aminotetralin and N-propyl derivative, 7-methoxy-2-aminotetralin and N-propyl, 8-methoxy-2-aminotetralin and N-propyl derivative, (S)-2-(methoxymethyl)pyrrolidine, (S)-2-(methylamino)propiophenone, D-N-methylamphetamine, 2-(4′-methylbenzyl)benzylamine, 2-(4′methylbenzyl)-N′N′-dimethylbenzylamine, 2-(4′-methylbenzyl)-N-hydroxyethyl-benzylamine, 2-methyl-3′-bromobenzylamine, 2-methyl-4′-bromobenzylamine, 2-methyl-4′-bromobenzylamine hydrochloride, 2-methyl-4′-chlorobenzylamine, 2-methyl-2′-methoxybenzylamine, 2-methyl-3′-methoxybenzylamine, 1-methyl-3′-methoxybenzylamine, 2-methyl-4′-methoxybenzylamine, 2-methyl-4′-methylbenzylamine, N-methyl-2-methylbenzylamine, N-methyl-2-(1′-naphthyl)-ethylamine, 2-methyl-2′-nitrobenzylamine hydrochloride, 2-methyl-4′-nitrobenzylamine hydrochloride, 1-methyl-3-phenylpropylamine, 2-(1′-naphthyl)ethylamine, 2,(2′-naphthyl)ethylamine, phenylalaninol, (R)1-phenyl-3-aminobutane, 2-phenylglycinol, 1-phenylpropylamine, 2-phenyl-1-propylamine, (S)-prolinol, 1-threoninol, N-acetyl-2-phenylglycinol, dinaphthylprolinol, 2-methylpiperazine, piperidinol, quinuclidinol and combinations thereof.  
   
   
       21 . The kit of  claim 1  wherein each substantially identical container has an attached unique marking to facilitate identification.  
   
   
       22 . The kit of  claim 1  wherein the unique marking is a bar code, an alphanumeric code, or combinations thereof.  
   
   
       23 . The kit of  claim 1  wherein the containers, rack, sealant and stopper are all stable at temperatures between with −20° C. to 120° C. and inert to the racemate, solvent and resolving agent.