US2007184119A1PendingUtilityA1

Surface modified protein microparticles

60
Individually held — no corporate assignee on recordPriority: Jun 17, 2003Filed: Apr 10, 2007Published: Aug 9, 2007
Est. expiryJun 17, 2023(expired)· nominal 20-yr term from priority
Inventors:Kenneth S. SuslickFarah Jean-Jacques ToublanStephen A. BoppartDaniel Marks
A61K 49/001
60
PatentIndex Score
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Cited by
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References
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Claims

Abstract

A microparticle contains a cross-linked protein shell, and a surface coating.

Claims

exact text as granted — not AI-modified
1 . (canceled)  
   
   
       2 . (canceled)  
   
   
       3 . The method of  claim 33 , wherein the surface coating comprises polyethylene glycol.  
   
   
       4 - 6 . (canceled)  
   
   
       7 . The method of  claim 33 , wherein the surface coating comprises a second protein.  
   
   
       8 . (canceled)  
   
   
       9 . The method of  claim 7 , wherein the second protein is an antibody.  
   
   
       10 . The method of  claim 33 , wherein the cross-linked protein shell comprises cross-linked albumin.  
   
   
       11 . The method of  claim 3 , wherein the cross-linked protein shell comprises cross-linked albumin.  
   
   
       12 . (canceled)  
   
   
       13 . The method of  claim 34 , wherein the cross-linked protein shell comprises cross-linked albumin.  
   
   
       14 . The method of  claim 34 , wherein the particles are colloidal particles selected from the group consisting of ceramics, metals and semiconductors.  
   
   
       15 . The method of  claim 34 , wherein the particles are selected from the group consisting of melanin, carbon, gold, and silica.  
   
   
       16 . (canceled)  
   
   
       17 . The method of  claim 3 , wherein the polyethylene glycol contains a ligand for a cell-surface receptor.  
   
   
       18 . The method of  claim 17 , wherein the ligand is folate.  
   
   
       19 - 21 . (canceled)  
   
   
       22 . (canceled)  
   
   
       23 . (canceled)  
   
   
       24 . The method of  claim 36 , wherein the particles comprise melanin, carbon or gold.  
   
   
       25 . The method of  claim 33 , wherein the microparticle further comprises a core comprising a pharmaceutically active compound.  
   
   
       26 . The microparticle method of  claim 33 , wherein the microparticle further comprises a core comprising a member selected from the group consisting of Gd complexes, melanin, colloidal gold, iron oxide, titanium dioxide, and fluorocarbons.  
   
   
       27 . (canceled)  
   
   
       28 . The method of  claim 34 , wherein the microparticle further comprising a core comprising a member selected from the group consisting of Gd complexes, melanin, colloidal gold, iron oxide, titanium dioxide, and fluorocarbons.  
   
   
       29 . (canceled)  
   
   
       30 . (canceled)  
   
   
       31 . The method of  claim 33 , wherein the cross-linked protein shell comprises at least one cross-linked protein, the protein selected from the group consisting of hemoglobin, pepsin, immunoglobulin, lipase, peroxidase and myoglobin.  
   
   
       32 . The method of  claim 34 , wherein the cross-linked protein shell comprises at least one cross-linked protein, the protein selected from the group consisting of hemoglobin, pepsin, immunoglobulin, lipase, peroxidase and myoglobin.  
   
   
       33 . A method of making a microparticle, comprising: 
 forming a cross-linked protein shell, and    attaching a surface coating to the cross-linked protein shell.    
   
   
       34 . A method of making a microparticle, comprising: 
 forming a cross-linked protein shell, and    attaching a surface coating to the cross-linked protein shell,    wherein the surface coating comprises particles.    
   
   
       35 . The method of  claim 34 , wherein the microparticle has a surface charge and the particles comprise colloidal particles, said colloidal particles have a charge opposite the surface charge.  
   
   
       36 . A method of making a microparticle, comprising: 
 mixing an aqueous solution of a protein with particles suspended in oil, to form a mixture; and    irradiating the mixture with ultrasound to cross-link the protein and form the microparticle.

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