US2007180543A1PendingUtilityA1
Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties
Est. expirySep 8, 2020(expired)· nominal 20-yr term from priority
C07K 14/4747A61P 35/00G01N 33/5082C07K 14/495G01N 2500/10A01K 2217/05
51
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Claims
Abstract
The present invention provides methods and compositions for drug screens to identify and characterize agents that are agonistic or antagonistic to activation of the promoter region of the NAG-1 gone. Activation of the NAG-1 gene is associated with the apoptotic elimination of cancer cells both in vitro and in vivo. The invention also provides novel promoter region sequences of the NAG-1 gene.
Claims
exact text as granted — not AI-modified1 - 14 . (canceled)
15 . A non-human transgenic animal comprising a nucleic acid comprising SEQ ID NO: 3.
16 . The non-human transgenic animal of claim 15 , wherein the non-human transgenic animal comprises a nucleic acid comprising SEQ ID NO: 1.
17 . The non-human transgenic animal of claim 15 , wherein the nucleic acid comprising SEQ ID NO: 3 further comprises a nucleic acid sequence that encodes NAG-1.
18 . The non-human transgenic animal of claim 16 , wherein the nucleic acid comprising SEQ ID NO: 1 further comprises a nucleic acid sequence that encodes NAG-1.
19 . The non-human transgenic animal of claim 15 , wherein the nucleic acid comprising SEQ ID NO: 3 further comprises a heterologous reporter construct, and the nucleic acid comprising SEQ ID NO: 3 directs transcription of the heterologous reporter construct.
20 . The non-human transgenic animal of claim 16 , wherein the nucleic acid comprising SEQ ID NO: 1 further comprises a heterologous reporter construct, and the nucleic acid comprising SEQ ID NO: 1 directs transcription of the heterologous reporter construct.
21 . The non-human transgenic animal of claim 15 , wherein the non-human transgenic animal is a murine.
22 . The non-human transgenic animal of claim 16 , wherein the non-human transgenic animal is a murine.
23 . The non-human transgenic animal of claim 17 , wherein the non-human transgenic animal is a murine.
24 . The non-human transgenic animal of claim 18 , wherein the non-human transgenic animal is a marine.
25 . The non-human transgenic animal of claim 19 , wherein the non-human transgenic animal is a murine.
26 . The non-human transgenic animal of claim 20 , wherein the non-human transgenic animal is a murine.Join the waitlist — get patent alerts
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