US2007172814A1PendingUtilityA1

Method of Testing the Safety and Efficacy of a Drug

51
Individually held — no corporate assignee on recordPriority: Nov 10, 2003Filed: Jan 30, 2007Published: Jul 26, 2007
Est. expiryNov 10, 2023(expired)· nominal 20-yr term from priority
Inventors:Albert Li
C12M 35/08C12M 25/04C12M 23/12C12N 5/0662
51
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

A method of testing the safety and efficacy of a drug in a culture tray having a plurality of wells surrounded by a chamber wall configured to contain a liquid volume. The method includes depositing different cells of an organism in separate wells of the culture dish, depositing a harmful agent in another of the wells, interconnecting the wells via a fluid medium and introducing a dose of the drug into the fluid medium.

Claims

exact text as granted — not AI-modified
1 . A method of testing the safety and efficacy of a drug in a culture tray having a plurality of wells surrounded by a chamber wall configured to contain a liquid volume, comprising: 
 depositing different cells of an organism in separate wells of the culture dish;    depositing a harmful agent in another of the wells;    interconnecting the wells via a fluid medium; and    introducing a dose of the drug into the fluid medium.    
     
     
         2 . The method of  claim 1 , further comprising: 
 determining whether the different cells of the organism are harmed by the dose of the drug.    
     
     
         3 . The method of  claim 2 , further comprising: 
 determining whether growth of the harmful agent is diminished by the dose of the drug.    
     
     
         4 . The method of  claim 3 , further comprising: 
 increasing the dose of the drug if the different cells of the organism are not harmed and the growth of the harmful agent is not diminished.    
     
     
         5 . The method of  claim 1 , wherein the harmful agent comprises tumor cells.  
     
     
         6 . The method of  claim 5 , wherein the drug comprises an anti-tumor medication.  
     
     
         7 . The method of  claim 1 , wherein the different cells of the organism comprise liver, kidney, heart, lung, spleen, and brain cells of the human body.  
     
     
         8 . The method of  claim 1 , further comprising: 
 increasing the dose of the drug until the drug harms the different cells of the organism; and    designating the dose of the drug at which the different cells of the organism are harmed as a toxic dose level.    
     
     
         9 . The method of  claim 1 , further comprising: 
 increasing the dose of the drug until the effect of the harmful agent is reduced; and    designating the dose of the drug at which the effect of the harmful agent is reduced as an effective dose level.    
     
     
         10 . The method of  claim 1 , wherein: 
 the harmful agent comprises cholesterol;    the drug comprises an anti-cholesterol drug; and    the different cells include liver cells.    
     
     
         11 . The method of  claim 1 , wherein: 
 the harmful agent comprises cancer cells; and    the drug includes an undesirable toxicity above a certain dose.    
     
     
         12 . The method of  claim 1 , further comprising: 
 depositing one or more culture medium in the separate wells.    
     
     
         13 . The method of  claim 1 , further comprising: 
 culturing the different cells in the separate wells.    
     
     
         14 . A method of simultaneously conducting multiple tests of the safety and efficacy of a drug in a culture tray having more than one set of wells, each set of wells being segregated in a chamber, comprising: 
 depositing different cells of an organism in separate wells in each chamber;    depositing a harmful agent in one of the wells in each chamber;    interconnecting the wells in each chamber via a fluid medium; and    introducing a dose of the drug into the fluid medium in each chamber with the dose of the drug being varied in each chamber.    
     
     
         15 . The method of  claim 14 , further comprising: 
 providing the tray segregated into  12  chamber units each having a chamber wall surrounding 8 of the wells.    
     
     
         16 . The method of  claim 14 , further comprising: 
 providing the tray segregated into  64  chamber units each having a chamber wall surrounding 6 of the wells.    
     
     
         17 . The method of  claim 14 , further comprising: 
 providing the tray segregated into  256  chamber units each having a chamber wall surrounding 6 of the wells.    
     
     
         18 . The method of  claim 14 , further comprising: 
 depositing a one or more culture medium in the separate wells in each chamber.    
     
     
         19 . The method of  claim 14 , further comprising: 
 culturing the different cells in the separate wells.    
     
     
         20 . A method of testing the safety and efficacy of a drug in a culture tray having a plurality of wells surrounded by a chamber wall configured to contain a liquid volume, comprising: 
 depositing a first cell type in a first well and a second cell type in a second well;    depositing a harmful agent in a third well;    interconnecting the first, second and third well via a fluid medium contained by the chamber wall;    introducing a dose of the drug into the fluid medium;    determining whether the first cell type or the second cell type are harmed by the dose of the drug; and    determining whether growth of the harmful agent is inhibited by the dose of the drug.

Join the waitlist — get patent alerts

Track US2007172814A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.