US2007167412A1PendingUtilityA1
Halocombstatins and methods of synthesis thereof
Est. expirySep 24, 2023(expired)· nominal 20-yr term from priority
C07C 43/23C07F 9/12
53
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Claims
Abstract
The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.
Claims
exact text as granted — not AI-modified1 . A compound having a structure as follows:
wherein X is F, Cl, Br or I.
2 . A compound having a structure as follows:
wherein X is F, Cl, Br or L and R is a metal cation such as Na, Li, K, Cs, Rb, Ca, Mg or is morpholine, pipenidine, glycine-OCH 3 , tryptophan-OCH 3 or NH(CH 2 OH) 3 .
3 . A compound having a stucture as follows:
wherein X is F, Cl, Br or I, and Z is a metal cation such as Na, Li, K, Cs, Rb, Ca, Mg or is morpholine, piperidine, glycine-OCH 3 , typtophan-OCH 3 or NH(CH 2 OH) 3 .
4 . The compound of claim 1 wherein X═F and the compound is in the Z configuration.
5 . The compound of claim 1 wherein X═I and the compound is in the Z configuration.
6 . The compound of claim 2 wherein X═F.
7 . The compound of claim 2 wherein X═I.
8 . The compound of claim 3 wherein X═I.
9 . A method for treating cancer comprising administering to a human or mammal an effective amount of a compound of claim 1 .
10 . A method for treating cancer comprising administering to a human or mammal an effective amount of a compound of claim 2 .
11 . A method for treating cancer comprismg administering to a human or mammal an effective amount of a compound of claim 3 .
12 . The method of claim 9 wherein the cancer is thyroid cancer and in the compound X═I.
13 . The method of claim 10 wherein tihe cancer is thyroid cancer and in the compound X═I.
14 . The method of claim 11 wherein tihe ecacer is thyroid cancer and in the compound X═I.
15 . A pharmaceutical composition comprsing a compound of claim 1 and a pharmaceutically acceptable carrier therefor.
16 . A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier therefor.
17 . A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier therefor.Join the waitlist — get patent alerts
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