Metabolic uncoupling therapy

Abstract

A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

1 - 36 . (canceled)  
     
     
         37 . A method of metabolic uncoupling therapy comprising: 
 analyzing a specific physiologic process, including delineating the metabolic pathways related to reductive stress;    identifying a plurality of MUT agents that modulate said metabolic pathways by influencing electron flux; and    formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.    
     
     
         38 . A method of metabolic uncoupling therapy as in  claim 37  comprising: 
 including an MUT agent in said combination based on said agent's secondary properties.    
     
     
         39 . A method as in  claim 37 , further comprising: 
 selecting a plurality of MUT agents based on their synergistic interactions with each other.    
     
     
         40 . A method as in  claim 37 , further comprising: 
 combining specific amounts and ratios of said plurality of MUT agents in a MUT formulation for administration in a prescribed manner for a prescribed period of time.    
     
     
         41 . A method of promoting weight loss or fat burning in a human or for treating hepatic steatosis, or hyperlipidemia in a human, said method comprising orally or parenterally administering to the human, for a therapeutically effective period, a composition comprising: 
 two or more Group 1 agents;    one or more Group 4 agents;    two or more Group 5 agents; and    one or more Group 6 agents;    wherein said Group 1 agents are selected from a group consisting of trimethylglycine (TMG), choline, phosphatidyl choline, S-adenosyl methionine (SAMe), carnitine, acetyl L-carnitine (ALC), propionyl carnitine, myo-inositol, sphingomyelin, glycerylphosphorylcholine, and acetylcholine;    said Group 4 agents are selected from a group consisting of pyruvate (PYR), aspartate (ASP), glycine (GLY), and serine (SER);    said Group 5 agents are selected from a group consisting of folate, riboflavin, B1, B3, niacinamide, nicotinamide, polynicotinate, B6, B12, biotin, pantothenic acid, riboflavin, and related chemical species; and    said Group 6 agents are selected from a group consisting of coenzyme Q10, alpha lipoic acid (ALA), and acetoacetate; and wherein    said agents are present in said composition in effective amounts for promoting weight loss or fat burning in a human or for treating hepatic steatosis or hyperlipidemia in a human.    
     
     
         42 . A method as in  claim 41  wherein said composition further comprises a Group 2 agent selected from a group consisting of creatine and folic acid.  
     
     
         43 . A method as in  claim 41  wherein said composition further comprises a Group 3 agent selected from a group consisting of docosahexanoic acid (PHA), eicosapentanoic acid (EPA), and albumin.  
     
     
         44 . A method as in  claim 41  wherein said composition further comprises a Group 7 agent, selected from a group consisting of anti-oxidant polyphenolic agents and desferoximine.  
     
     
         45 . A method as in  claim 41  wherein said composition comprises TMG, carnitine, aspartate, folate, vitamin B6, and coenzyme Q10.  
     
     
         46 . A method as in  claim 45  wherein said composition further comprises alpha lipoic acid (ALA), phosphatidyl choline, SAMe, and eicosapentanoic acid (EPA).  
     
     
         47 . A method as in  claim 46  wherein said composition further comprises biotin, hydroxycitric acid, and vitamin B12.  
     
     
         48 . A method as in  claim 41  wherein said composition further comprises an agent selected from the group consisting of medium chain triglycerides (MCT), to cotrienols, guggulipid, conjugated linoleic acid (CLA)  
     
     
         49 . A method as in  claim 41  wherein said composition comprises phosphatidyl choline, SAMe, pyruvate, folate, vitamin B1, and alpha lipoic acid (ALA).  
     
     
         50 . A method as in  claim 49  wherein said composition further comprises creatine, green tea leaf extract, eicosapentanoic acid (EPA) and acetyl L-carnitine (ALC).  
     
     
         51 . A method as in  claim 50  wherein said composition further comprises conjugated linoleic acid (CLA), vitamin B2, vitamin B3, vitamin B5 and vitamin B6.  
     
     
         52 . A method as in  claim 41  wherein said composition comprises TMG, SAMe, aspartate, folate, and niacinamide.  
     
     
         53 . A method as in  claim 52  wherein said composition further comprises choline, biotin, creatine and HCA.  
     
     
         54 . A method as in  claim 53  wherein said composition further comprises chromium, carnitine, alpha lipoic acid (ALA), and medium chain triglycerides (MCT).  
     
     
         55 . A method as in  claim 41  wherein said composition comprises TMG, choline, guggulipid, tocotrienois, folate, and ALA.  
     
     
         56 . A method as in  claim 55  wherein said composition further comprises coenzyme Q10, myo-inositol, biotin, pantothenic acid, and pycidoxine.